Abstract:
:In order to clarify the interaction mechanism between organotin compounds and organisms, the effects of these compounds on the development of a benthonic filter-feeding invertebrate were studied. Embryos of the ascidian Styela plicata were obtained in laboratory by cross-fertilization and their development was followed in vivo after incubation with 0.1, 1, and 10 microM organotin compounds for various exposure times. Moreover, embryos selected at opportune stages after incubation with 10 microM tributyltin (TBT) or triphenyltin (TPT) for 1 hr were observed at the electron microscope to recognize cell alterations. Results indicate that organotins significantly affect all stages of ascidian development in a dose- and time-dependent manner and the most sensitive stages are gastrula and neurula. These compounds are able to block development, giving rise to anomalous embryos with irreversible effects. The order of inhibition appears to be strongly dependent on the organotin liposolubility: TBT > dibutyltin (DBT) > monobutyltin (MBT) and TPT > tricyclohexyltin (TCHT). The mitosis block of blastomeres in the early stages may be related to an inhibition of the microtubule polymerization. Observations with light and electron microscopes reveal globeshaped blastomeres with large intercellular spaces in the morula and gastrula stages, suggesting a toxic damage with alteration of the cytoskeleton. Moreover, the occurrence of electron-dense precipitates of organotins in the inner membrane of mitochondria and morphological changes of their cristae suggest an inhibitory effect on oxidative phosphorylation which is conspicuous in the gastrula stage. In this stage, the size of the electron-dense aggregates grow from 50-70 to 110-170 nm, while at the same time the alteration of the cristae increases.
journal_name
Ecotoxicol Environ Safjournal_title
Ecotoxicology and environmental safetyauthors
Cima F,Ballarin L,Bressa G,Martinucci G,Burighel Pdoi
10.1006/eesa.1996.0097subject
Has Abstractpub_date
1996-11-01 00:00:00pages
174-82issue
2eissn
0147-6513issn
1090-2414pii
S0147-6513(96)90097-4journal_volume
35pub_type
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