Abstract：
:We have previously demonstrated that one dimensional (1D) proton (1H) magnetic resonance spectroscopy (MRS) can distinguish normal thyroid tissue from thyroid carcinoma using a spectral ratio of peak intensity at 1.7 ppm/0.9 ppm. Two dimensional (2D) 1H-MRS allows identification of specific molecules that have overlapping peaks in the 1D-MR spectrum. Specimens from 93 consecutive thyroid nodules were examined using 2D 1H-MRS on a Bruker AM-360 wide-bore spectrometer. There was a progressive increase in lipid cross peaks assigned to di-/triglycerides when comparing colloid/hyperplastic nodules to follicular adenoma, and adenoma to carcinoma. A specific cross peak attributable to cholesterol/cholesteryl esters was commonly seen in carcinomas. In contrast, two unassigned cross peaks unique to the thyroid were more prevalent in benign lesions. There was an overall increase in cross peaks attributable to cell surface fucosylation in carcinoma when compared to benign lesions, although the fucose spectral pattern was not specific for cancer. On this basis, a spectral ratio of peak intensity at 2.05 ppm/0.9 ppm more clearly distinguished benign follicular adenoma from carcinoma. 2D 1H-MRS thus identifies chemical changes that allow more specific tissue characterization of thyroid neoplasms.
journal_name
World J Surgjournal_title
World journal of surgeryauthors
Mackinnon WB,Delbridge L,Russell P,Lean CL,May GL,Doran S,Dowd S,Mountford CEdoi
10.1007/s002689900128subject
Has Abstractpub_date
1996-09-01 00:00:00pages
841-7issue
7eissn
0364-2313issn
1432-2323journal_volume
20pub_type
杂志文章abstract：INTRODUCTION:Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expr...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-4331-x
更新日期：2018-02-01 00:00:00
abstract：:The well-known poor prognosis of proximal bile duct cancer is due to its unfortunate anatomical location and its late diagnosis. Successful tumor resection, which is considered to be optimal treatment, depends on many factors. Eighty-eight patients suffering from proximal bile duct cancer underwent surgical exploratio...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-003-6656-x
更新日期：2003-06-01 00:00:00
abstract：:Thyrotoxicosis is the clinical syndrome that results when tissues are exposed to high levels of circulating thyroid hormones. In most instances thyrotoxicosis is due to hyperthyroidism, a term reserved for disorders characterized by overproduction of thyroid hormones by the thyroid gland. Nevertheless, thyrotoxicosis ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s002680010228
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:Recurrent renal hyperparathyroidism (HPT) is a serious problem after parathyroidectomy (PTx). We evaluated the frequency of graft-dependent recurrent HPT and the clinical outcomes after removal of the autograft. METHODS:Between March 1980 and January 2009, 2660 patients underwent total PTx with forearm auto...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0412-9
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Peritoneal adhesions are recognized as an important cause for patient morbidity, but complications related to adhesions occur relatively late after the original operation. Therefore preoperative consent may not adequately reflect the proportions of the problem. METHODS:A total of 200 patients admitted for i...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1007/s00268-008-9917-x
更新日期：2009-04-01 00:00:00
abstract：:This study described the various components of access to care for resectable colorectal cancer, and correlated the timeliness of these components with patient satisfaction. With a prospective/retrospective cohort design, all patients undergoing surgical resection for primary colorectal cancer from 2/1/01 to 15/12/01, ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-7955-1
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:The aim of this study was to assess the efficacy of the Nd:YAG laser for treating stage I squamous cell carcinoma (SCC) of the lip. The retrospective study was performed in a tertiary care referral hospital in northern India. METHODS:In January 2007 the records of patients treated by Nd:YAG laser ablation o...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-007-9363-1
更新日期：2008-04-01 00:00:00
abstract：:During the past four decades, especially in recent years, various active adjuvant therapies combined with surgery have improved the outcome in cases of cancer of the esophagus. However, no optimum adjuvant therapy has been determined. From 1981 to 1992, 341 patients with regional and distant node metastasis who underw...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/BF00316819
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:The recent development and spread of ultrasonography and ultrasonography-guided fine needle aspiration biopsy (FNAB) has facilitated the detection of small papillary microcarcinomas of the thyroid measuring 1 cm or less (PMC). The marked difference in prevalence between clinical thyroid carcinoma and PMC det...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-009-0303-0
更新日期：2010-01-01 00:00:00
abstract：:Outside Japan portosystemic shunts have been favored as the surgical procedure of choice for the management of portal hypertension of noncirrhotic etiology. Devascularization procedures have resulted in high rebleed rates probably owing to a limited extent of devascularization. We performed this study to assess the ef...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s002689900641
更新日期：1999-11-01 00:00:00
abstract：:The principles of minimally invasive parathyroidectomy include the successful preoperative localization of a solitary adenoma, a targeted operative approach that does not disturb the normal parathyroid glands, and intraoperative confirmation of excision of all hypersecreting parathyroid tissue. By providing real-time ...
journal_title：World journal of surgery
pub_type： 杂志文章,评审
doi：10.1007/s00268-004-7641-8
更新日期：2004-12-01 00:00:00
abstract：:Nuss described a minimally invasive technique for correcting pectus excavatum in children. A curved stainless-steel bar is inserted behind the sternum through the chest cavity with the convex surface face down, then rotated 180 degrees to elevate the sternum and correct the deformity. The procedure gained wide accepta...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6519-x
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Seroma formation is a frequent postoperative complication following open ventral hernia repair (OVHR), especially in cases requiring wide subcutaneous dissection (WSD). The aim of this study was to evaluate the effectiveness of a new low-thrombin fibrin sealant for seroma prevention. METHODS:A total of 60 c...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2691-z
更新日期：2014-11-01 00:00:00
abstract：OBJECTIVE:Gastroesophageal reflux disease (GERD) symptoms are commonly reported in primary hyperparathyroidism (pHPT). Although a calcium-mediated cause-and-effect relationship has been suggested, it remains unknown if parathyroidectomy improves GERD symptoms. METHODS:Over a 22-month period, 1,175 (39%) of 3,000 conse...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2876-5
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The technical complexity of pancreatic resection has made it a specialized procedure performed in high-volume centers. It has been shown that patients operated on in high-volume pancreatobiliary centers have fewer complications and better survival. The purpose of this study was to share our experience with a...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-014-2644-6
更新日期：2014-10-01 00:00:00
abstract：:The purpose of this study was to elucidate the function of the sphincter of Oddi (SO) in patients with juxtapapillary duodenal diverticula (JDDs). The SO function was evaluated by intraoperative biliary manometry in three groups of patients. Group 1 consisted of nine patients with JDDs and a dilated common bile duct (...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF00308647
更新日期：1995-03-01 00:00:00
abstract：:Treacher Collins Syndrome is a rare bilateral congenital deformity occurring in 1 in 10,000 births. It is also known, in the European literature, as Franceschetti Syndrome, and is additionally known as mandibulofacial dysostosis. It is a syndrome with a very wide spectrum of manifestations characterized by distortions...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01660753
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:The role of preoperative imaging and the usability of different imaging modalities is highly variable and controversial in reduction mammaplasty patients. Our study describes the imaging process in a single center in regard to modality selection, age and timing, and of the association between imaging and his...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-017-3920-z
更新日期：2017-08-01 00:00:00
abstract：:The surgical management of pancreatic islet cell carcinomas poses a complicated set of questions resulting from their rare occurrence and the difficulty in establishing a diagnosis in early cases or, conversely, the problems inherent in dealing with metastatic disease. However, because their biologic behavior is rathe...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/BF01655109
更新日期：1993-07-01 00:00:00
abstract：:The aim of this study was to investigate the prognostic factors for hepatocellular carcinoma (HCC) in patients without cirrhosis who underwent hepatectomy. Between 1986 and 1998 a total of 197 men and 57 women with noncirrhotic HCC underwent hepatic resection in the Department of Surgery, Chang Gung Memorial Hospital,...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6708-7
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:The aim of this study was to determine the predictive value of the preoperative three-dimensional reconstructed volume (3D volumetry) for outcomes of laparoscopic splenectomy. The impact of splenomegaly on the feasibility of laparoscopic splenectomy is still debated. We hypothesized that splenic volumetry ma...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1789-4
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Vibrio vulnificus infection can progress rapidly in skin or soft tissue, and it is potentially life-threatening. The purpose of the present study was to explore the predictors of mortality in patients with V. vulnificus infections of skin or soft tissue. METHODS:The medical records of 119 consecutive patien...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-010-0455-y
更新日期：2010-07-01 00:00:00
abstract：:In the original article, the units indicated on the y-axes of Fig. 3 are incorrectly labelled. The correct label is pg/mL. Following is the corrected Fig. 3. ...
journal_title：World journal of surgery
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00268-020-05520-3
更新日期：2020-07-01 00:00:00
abstract：:The angiogenic factor called vascular endothelial growth factor (VEGF)-D is a ligand for VEGF receptor-2 (VEGFR-2/KDR) and receptor-3 (VEGFR-3/Flt-4). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-005-0076-z
更新日期：2005-12-01 00:00:00
abstract：:The release of the neuronal protein S-100B into the circulation has been suggested as an early indication of cellular brain damage. The objective of this prospective pilot study was to determine S-100B serum levels in patients undergoing cross-clamping during carotid endarterectomy (CEA) and to correlate the results w...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6547-6
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:Delayed recovery of gastrointestinal (GI) motility is a common complication following surgery. TZP-101/ulimorelin is a macrocyclic peptidomimetic ghrelin receptor agonist with GI promotility effects that significantly accelerates time to recovery of GI motility compared to placebo following partial colectomy...
journal_title：World journal of surgery
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00268-011-1335-9
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:A lower-pitched voice is one of the most common voice alterations after thyroidectomy without laryngeal nerve injury. The aim of this study was to evaluate the acoustic and stroboscopic changes and the treatment outcomes in patients with a lower-pitched voice with the goal of eventually establishing a therap...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-013-2062-1
更新日期：2013-08-01 00:00:00
abstract：BACKGROUND:Surgery is increasingly recognized as a means to reduce the morbidity and mortality of disabling impairments in resource-limited environments. We sought to estimate the burden of surgically correctable disabling impairments and the cost-effectiveness of their treatment among children in a large refugee camp....
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-012-1899-z
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:Primary hyperparathyroidism (PHPT) is a common endocrine disorder that predominantly affects patients >60 and is increasing in prevalence. Identifying risk factors for poor outcomes after parathyroidectomy in older adults will help tailor operative decision making. The impact of frailty on surgical outcomes ...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-018-4629-3
更新日期：2018-10-01 00:00:00
abstract：:This study was first designed to investigate systematically the kinetics of surface expression of scavenger receptors (SRs) and CD14 on alveolar macrophages in vivo and in vitro and their relation with local pro- and antiinflammatory responses in endotoxemia. The expression of SR and CD14 in lungs was down- and up-reg...
journal_title：World journal of surgery
pub_type： 杂志文章
doi：10.1007/s00268-002-6548-5
更新日期：2003-01-01 00:00:00
