Abstract:
:121 patients with advanced ovarian cancer resistant to or relapsing following platinum-based chemotherapy participated in this prospective randomised multicenter study. The second-line treatment was indicated according to the relapse-free interval. 36 assessable patients were resistant to platinum-based chemotherapy or relapsed within 12 months following primary surgery. This group of patients with early relapse was randomized to oral or parenteral etoposide. 82 patients relapsed within an interval longer then 12 months following primary surgery; these patients with delayed relapse underwent a secondary tumour-debulking surgery. The data of this group of patients with delayed relapse will be published as soon as the time of observation allows adequate results. In this paper the efficiency of etoposide in the patients with early relapse is analysed according to the application form of the drug (oral vs. parenteral). No statistically significant difference in response rate, toxicity, and median survival time was found between the oral (n = 18) and parenteral (n = 18) treatment. In both application groups the response rate was 22%, the median survival time 14 and 13 months respectively. Alopecia and leucopenia were the most frequent toxicities. As a result etoposide is efficient in unfavorable ovarian cancer patients with early relapse. Because of better compliance etoposide should be administered parenterally. In respect of response rate and median survival time, etoposide is comparable with paclitaxel.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Kuhn W,Schmalfeldt B,Dose J,Pache L,Ulm K,Freitag K,Jänicke F,Graeff Hdoi
10.1055/s-2007-1022252subject
Has Abstractpub_date
1996-02-01 00:00:00pages
105-10issue
2eissn
0016-5751issn
1438-8804journal_volume
56pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::Recent developments and improvements in prenatal diagnostic methods, and in particular antenatal ultrasonography, have made intrauterine detection of fetal abnormalities possible. Most defects are best treated after birth, only a few disorders are potentially amenable to surgical treatment in utero. Studies in animal ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1036361
更新日期:1985-08-01 00:00:00
abstract::Germany faces the challenge of enforcing the academization of midwifery training in the upcoming months in order to comply with Directive 2013/55/EU. This paper outlines the related developments and challenges. At the moment, midwifery training in Germany is still predominantly carried out in technical colleges. In 20...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0958-9519
更新日期:2019-08-01 00:00:00
abstract::The regular Huffman vaginoscope is fitted with an endotracheal sleeve to obtain a balloon vaginoscope. The balloon vaginoscope makes inspection of the cervix in children much easier, and facilitates the removal of foreign bodies from the vagina of children. Vaginoscopy can be learned easier with the balloon vaginoscop...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract::An impressive breakthrough of Wertheim's original intentions became evident on analysing the observations, experiences and results obtained from the early 'forties right up to the 'eighties of this century in various hospitals such as the Pathological Institute of the famous Berlin "Charité" Hospital and the Departmen...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1036397
更新日期:1989-05-01 00:00:00
abstract::Permanent disturbances of bladder function are the most unpleasant and least tolerated side effects in patients, who underwent Wertheim hysterectomy because of cervical cancer. The cause of this problem with respect to the radical nature of the operation in relation to the possibly and responsible anatomical structure...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022927
更新日期:1993-08-01 00:00:00
abstract::From January 1976 to March 1982 119 microsurgical reversals were performed. Most of these women were not older than 30 years at the time of sterilization. A new partnership was the main reason for a request of reversal. Up to now 69 patients (58,0%) achieved an intrauterine pregnancy. Ectopic pregnancies occurred in 3...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037090
更新日期:1983-04-01 00:00:00
abstract::The introduction of percutaneous nephrostomy under xc-ray control or ultra-sonic control makes it possible to do the operation even in patients with a bad general condition. The decision for palliative urinary diversion in cases of cancer of the pelvis is therefore largely an ethical question. A group of patients with...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037150
更新日期:1982-10-01 00:00:00
abstract::Introduction PCOS is the most common endocrine syndrome in women of the reproductive age that has manifold effects on the life of affected women. Little scientific attention has been devoted to these women's sexual lives. Aim To investigate sexual quality of life in women with PCOS. Methods The sample size was n = 44....
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0828-7901
更新日期:2019-05-01 00:00:00
abstract::A laparotomy for a suspected cystic ovarian tumour which was thought to extent as far as the costal arch, was carried out on a 24-year-old patient with a long history of oligomenorrhea and sterility. Due to excessive oedema, both ovaries were tremendously enlarged. The right ovary was twisted 360 degrees. No haemorrha...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-02-01 00:00:00
abstract::After 15 years of clinical experiences with Clomiphen treatment it seemed desirable to investigate the efficiency of this kind of therapy under routine conditions in a crowded out-patient clinic. 314 patients treated from 1972--1974 have been included in this study. From 242 sterility patients 730 cycles could be foll...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Therapeutic results in advanced cervical cancer have not been showing any progress for more than 30 years. Only by means of systemic therapy does it seem possible, that further treatment results may be obtained similar to those in squamous cell carcinoma of the head and neck. Therefore, between 1985 and 1990 we tried ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1026177
更新日期:1991-06-01 00:00:00
abstract::Recurrence in Four Consecutive Pregnancies in a Patient: We report on the recurrence of HELLP-syndrome in four consecutive pregnancies in a patient. The observation of recurrence of this rare disorder (0.2-0.8% of all pregnancies) in an otherwise healthy patient points to an immunological or genetic predisposition for...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022295
更新日期:1996-09-01 00:00:00
abstract::The ovarian carcinoma-associated antigen CA-125 was determined in 144 women with various gynecological tumors (ovarian, breast, uterine), by using the heterologous monoclonal antibody OC-125. In 90% of the malignant ovarian tumors positive CA-125 values were correct, whereas their negative values were correct in 88% o...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036133
更新日期:1985-11-01 00:00:00
abstract::Several decisions of the Federal Supreme Court during the past 2 years judged questions of the admissibility of sterlizations by physicians. These decisions of the Supreme Court are fundamentally important since there is no statutory regulation. Based on the decisions of the Court, the physician must know the follow...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037268
更新日期:1982-03-01 00:00:00
abstract::368 urodynamically investigated women of the University Hospital of Innsbruck (Austria) were separated into four groups depending on their incontinence status (either stress incontinence or not) and depending on previous incontinence surgery. In this collective of patients, we compared the urethral length, the absolut...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036102
更新日期:1989-10-01 00:00:00
abstract::The present case report, which describes the transformation of a cystosarcoma phylloides into a "borderline case" and subsequently a fibrosarcoma, makes it clear that fibrosarcoma of the breast cannot always be regarded as a tumor which has developed primarily from mesenchymal breast tissue. Just as a benign cystosarc...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035979
更新日期:1986-11-01 00:00:00
abstract::287 women underwent surgery for ectopic pregnancy from January 1, 1979 to December 31, 1985. Prior to laparotomy, seven patients (2.4%) had applied for an induced abortion elsewhere in the absence of evidence of an intact intrauterine pregnancy. During these interventions, histological examination of the scraping was ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026573
更新日期:1989-02-01 00:00:00
abstract::During the past fifteen years strong evidence has accumulated that particular types of human papilloma viruses are involved in the aetiology of cervical cancer. Early reports suggested that women with cytological signs of papilloma virus infection have a significantly higher risk to develop cervical cancer. Recent stu...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract::The purpose of the present study is to determine differences in the postoperative character of pain between two study groups undergoing different techniques of hysterectomy. Therefore we examined 42 women. 21 women underwent combined laparoscopic and vaginal hysterectomy and 21 abdominal hysterectomies have been perfo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022348
更新日期:1994-11-01 00:00:00
abstract::In estradiol micro-crystalline suspension was injected into the ovary containing the corpus luteum in women who underwent hysterectomy. The same complete luteaolysis is in women who did not have hysterectomies was obtained. The conclusion is drawn that the prostaglandins which are formed in the uterus have no influenc...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::This is a report on a rare incident of an intrauterine foetal death with toxoplasmosis in the 25th week of pregnancy. The diagnosis could be made serologically as well as pathologically. The issues connected with serological screening for toxoplasmosis are discussed on the basis of this case. ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022334
更新日期:1994-09-01 00:00:00
abstract::The typical ultrasound findings in cases of fetal holoprosencephaly with hypotelorism and cyclopia are explained with reference to a case history. Hypotelorism was confirmed by measurement of the distance between the orbits of the fetus. ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036239
更新日期:1986-07-01 00:00:00
abstract::Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with sympt...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0972-2052
更新日期:2020-01-01 00:00:00
abstract::Seasonal variations in the incidence of the conception of multiple pregnancies are compared in the same population area in two centuries. 12,617 singleton and 101 twin pregnancies from 1803 to 1852 are compared to 63,967 singleton, 473 twin and 5 triplet pregnancies from 1965 to 1970. In both groups the percentage dec...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-02-01 00:00:00
abstract::The reliability of cervical cytology for the detection of premalignant and malignant disease is dependent on proper sampling of the transformation zone. The use of a cervical brush to collect enough endocervical cells is more effective, than the use of the conventional cotton swab. ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026332
更新日期:1991-01-01 00:00:00
abstract::Urodynamic parameters are changed by stress incontinence surgery. Our study, comparing pre- and postoperative measurements in 141 women with urinary stress incontinence, shows an increase of the transmission ratio in the proximal urethra and a decrease of depression factors in the proximal and mid urethra after surger...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036005
更新日期:1988-06-01 00:00:00
abstract::Relevant correlations between the level of the IQ and the reactions to gynaecological interventions and changes in the female reproductive system were detected. These are important in medical practice. The findings are based on psychometric studies in 400 to 500 women. First: Puberty and menarche are experienced in co...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract::The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::In 1959 Rauscher and Spurny questioned the advantages of routine lymphadenectomy in radical Wertheim operations compared to selective lymphadenectomies. Our present review disagrees with the above mentioned doubts. Rauscher and Spurny base their results on clinical staging of cancer of the cervix in cases from 1947 to...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract::In many cases, the sonography of the endometrium requires an exact pre-therapeutical interpretation. Apart from a hysteroscopy, this can take place by means of an improved version of a contrast hysterosonography, i.e. the Gel-KHSG. The technique and examination results are described here. This simple examination metho...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1026180
更新日期:1991-06-01 00:00:00