-Intravenous or oral etoposide therapy of platinum refractory ovarian cancer with early recurrence. Results of a prospective randomized study-.

Abstract:

:121 patients with advanced ovarian cancer resistant to or relapsing following platinum-based chemotherapy participated in this prospective randomised multicenter study. The second-line treatment was indicated according to the relapse-free interval. 36 assessable patients were resistant to platinum-based chemotherapy or relapsed within 12 months following primary surgery. This group of patients with early relapse was randomized to oral or parenteral etoposide. 82 patients relapsed within an interval longer then 12 months following primary surgery; these patients with delayed relapse underwent a secondary tumour-debulking surgery. The data of this group of patients with delayed relapse will be published as soon as the time of observation allows adequate results. In this paper the efficiency of etoposide in the patients with early relapse is analysed according to the application form of the drug (oral vs. parenteral). No statistically significant difference in response rate, toxicity, and median survival time was found between the oral (n = 18) and parenteral (n = 18) treatment. In both application groups the response rate was 22%, the median survival time 14 and 13 months respectively. Alopecia and leucopenia were the most frequent toxicities. As a result etoposide is efficient in unfavorable ovarian cancer patients with early relapse. Because of better compliance etoposide should be administered parenterally. In respect of response rate and median survival time, etoposide is comparable with paclitaxel.

authors

Kuhn W,Schmalfeldt B,Dose J,Pache L,Ulm K,Freitag K,Jänicke F,Graeff H

doi

10.1055/s-2007-1022252

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

105-10

issue

2

eissn

0016-5751

issn

1438-8804

journal_volume

56

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • [Problems of and possibilities in fetal surgery].

    abstract::Recent developments and improvements in prenatal diagnostic methods, and in particular antenatal ultrasonography, have made intrauterine detection of fetal abnormalities possible. Most defects are best treated after birth, only a few disorders are potentially amenable to surgical treatment in utero. Studies in animal ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1036361

    authors: Mrozik E

    更新日期:1985-08-01 00:00:00

  • The Academization of Midwifery in the Context of the Amendment of the German Midwifery Law: Current Developments and Challenges.

    abstract::Germany faces the challenge of enforcing the academization of midwifery training in the upcoming months in order to comply with Directive 2013/55/EU. This paper outlines the related developments and challenges. At the moment, midwifery training in Germany is still predominantly carried out in technical colleges. In 20...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0958-9519

    authors: Plappert C,Graf J,Simoes E,Schönhardt S,Abele H

    更新日期:2019-08-01 00:00:00

  • [The balloon vaginoscopy (author's transl)].

    abstract::The regular Huffman vaginoscope is fitted with an endotracheal sleeve to obtain a balloon vaginoscope. The balloon vaginoscope makes inspection of the cervix in children much easier, and facilitates the removal of foreign bodies from the vagina of children. Vaginoscopy can be learned easier with the balloon vaginoscop...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Terruhn V

    更新日期:1979-01-01 00:00:00

  • [4 decades of surgery of cervix cancer].

    abstract::An impressive breakthrough of Wertheim's original intentions became evident on analysing the observations, experiences and results obtained from the early 'forties right up to the 'eighties of this century in various hospitals such as the Pathological Institute of the famous Berlin "Charité" Hospital and the Departmen...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-2008-1036397

    authors: Ober KG

    更新日期:1989-05-01 00:00:00

  • [Late disorders of bladder function after Wertheim operation--an analysis of urodynamic parameters with reference to surgical radicality].

    abstract::Permanent disturbances of bladder function are the most unpleasant and least tolerated side effects in patients, who underwent Wertheim hysterectomy because of cervical cancer. The cause of this problem with respect to the radical nature of the operation in relation to the possibly and responsible anatomical structure...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022927

    authors: Debus-Thiede G,Maassen V,Dimpfl T,Klosterhalfen T,Kindermann G

    更新日期:1993-08-01 00:00:00

  • [Microsurgical reversal of sterilization: experiences and results in 119 cases].

    abstract::From January 1976 to March 1982 119 microsurgical reversals were performed. Most of these women were not older than 30 years at the time of sterilization. A new partnership was the main reason for a request of reversal. Up to now 69 patients (58,0%) achieved an intrauterine pregnancy. Ectopic pregnancies occurred in 3...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037090

    authors: Schlösser HW,Frantzen C,Mansour N,Verhoeven HC

    更新日期:1983-04-01 00:00:00

  • [Palliative urinary diversion in cases of cancer of the pelvis].

    abstract::The introduction of percutaneous nephrostomy under xc-ray control or ultra-sonic control makes it possible to do the operation even in patients with a bad general condition. The decision for palliative urinary diversion in cases of cancer of the pelvis is therefore largely an ethical question. A group of patients with...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037150

    authors: Casper F,Petri E

    更新日期:1982-10-01 00:00:00

  • Sexual Function and Socio-Sexual Difficulties in Women with Polycystic Ovary Syndrome (PCOS).

    abstract::Introduction PCOS is the most common endocrine syndrome in women of the reproductive age that has manifold effects on the life of affected women. Little scientific attention has been devoted to these women's sexual lives. Aim To investigate sexual quality of life in women with PCOS. Methods The sample size was n = 44....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0828-7901

    authors: Fliegner M,Richter-Appelt H,Krupp K,Brunner F

    更新日期:2019-05-01 00:00:00

  • [Extreme oedema of the ovaries: a contribution to conservative surgery for ovarian "tumours" (author's transl)].

    abstract::A laparotomy for a suspected cystic ovarian tumour which was thought to extent as far as the costal arch, was carried out on a 24-year-old patient with a long history of oligomenorrhea and sterility. Due to excessive oedema, both ovaries were tremendously enlarged. The right ovary was twisted 360 degrees. No haemorrha...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Kindermann G,Christ F

    更新日期:1977-02-01 00:00:00

  • [Results of routine treatment with Clomiphen (author's transl)].

    abstract::After 15 years of clinical experiences with Clomiphen treatment it seemed desirable to investigate the efficiency of this kind of therapy under routine conditions in a crowded out-patient clinic. 314 patients treated from 1972--1974 have been included in this study. From 242 sterility patients 730 cycles could be foll...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Gronau A,Lehmann F,Leidenberger F,Bettendorf G

    更新日期:1978-10-01 00:00:00

  • [Systemic therapy in recurrent and primary advanced cervix cancer].

    abstract::Therapeutic results in advanced cervical cancer have not been showing any progress for more than 30 years. Only by means of systemic therapy does it seem possible, that further treatment results may be obtained similar to those in squamous cell carcinoma of the head and neck. Therefore, between 1985 and 1990 we tried ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026177

    authors: Kaufmann M,Schmid H,Junkermann H,Schönig T,von Fournier D,Bastert G

    更新日期:1991-06-01 00:00:00

  • [HELLP syndrome: recurrence in 4 consecutive pregnancies].

    abstract::Recurrence in Four Consecutive Pregnancies in a Patient: We report on the recurrence of HELLP-syndrome in four consecutive pregnancies in a patient. The observation of recurrence of this rare disorder (0.2-0.8% of all pregnancies) in an otherwise healthy patient points to an immunological or genetic predisposition for...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022295

    authors: Beinder E,Hirschmann A,Wildt L,Junker H

    更新日期:1996-09-01 00:00:00

  • [Clinical significance of the tumor marker CA-125 for the preoperative diagnosis and postoperative management of patients with malignant ovarian cancers].

    abstract::The ovarian carcinoma-associated antigen CA-125 was determined in 144 women with various gynecological tumors (ovarian, breast, uterine), by using the heterologous monoclonal antibody OC-125. In 90% of the malignant ovarian tumors positive CA-125 values were correct, whereas their negative values were correct in 88% o...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036133

    authors: Sevelda P,Salzer H,Dittrich C,Spona J

    更新日期:1985-11-01 00:00:00

  • [The law and sterilization or permanent contraception (author's transl)].

    abstract::Several decisions of the Federal Supreme Court during the past 2 years judged questions of the admissibility of sterlizations by physicians. These decisions of the Supreme Court are fundamentally important since there is no statutory regulation. Based on the decisions of the Court, the physician must know the follow...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037268

    authors: Brenner G

    更新日期:1982-03-01 00:00:00

  • [Comparison of various length parameters of the urethra in 386 patients in relation to continence, menopausal status and age].

    abstract::368 urodynamically investigated women of the University Hospital of Innsbruck (Austria) were separated into four groups depending on their incontinence status (either stress incontinence or not) and depending on previous incontinence surgery. In this collective of patients, we compared the urethral length, the absolut...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036102

    authors: Anderl P,Kölle D

    更新日期:1989-10-01 00:00:00

  • [Potential malignancy of cystosarcoma phyllodes of the breast. A contribution to the histogenesis of fibrosarcoma].

    abstract::The present case report, which describes the transformation of a cystosarcoma phylloides into a "borderline case" and subsequently a fibrosarcoma, makes it clear that fibrosarcoma of the breast cannot always be regarded as a tumor which has developed primarily from mesenchymal breast tissue. Just as a benign cystosarc...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1035979

    authors: Kühn W,Rummel HH,Kübler H

    更新日期:1986-11-01 00:00:00

  • [Extrauterine pregnancies following "abortion" in cases with no indication of intrauterine pregnancy].

    abstract::287 women underwent surgery for ectopic pregnancy from January 1, 1979 to December 31, 1985. Prior to laparotomy, seven patients (2.4%) had applied for an induced abortion elsewhere in the absence of evidence of an intact intrauterine pregnancy. During these interventions, histological examination of the scraping was ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026573

    authors: Jaluvka V,Weitzel HK

    更新日期:1989-02-01 00:00:00

  • [The role of papillomaviruses in the etiology of cervix cancer].

    abstract::During the past fifteen years strong evidence has accumulated that particular types of human papilloma viruses are involved in the aetiology of cervical cancer. Early reports suggested that women with cytological signs of papilloma virus infection have a significantly higher risk to develop cervical cancer. Recent stu...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审

    doi:

    authors: von Knebel Doeberitz M

    更新日期:1990-07-01 00:00:00

  • [Postoperative pain in patients after conventional abdominal and endoscopic surgery hysterectomy--a comparative study].

    abstract::The purpose of the present study is to determine differences in the postoperative character of pain between two study groups undergoing different techniques of hysterectomy. Therefore we examined 42 women. 21 women underwent combined laparoscopic and vaginal hysterectomy and 21 abdominal hysterectomies have been perfo...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022348

    authors: Malik E,Scheidel P

    更新日期:1994-11-01 00:00:00

  • [Investigations into the hormonal regulation of the corpus luteum function in the human (author's transl)].

    abstract::In estradiol micro-crystalline suspension was injected into the ovary containing the corpus luteum in women who underwent hysterectomy. The same complete luteaolysis is in women who did not have hysterectomies was obtained. The conclusion is drawn that the prostaglandins which are formed in the uterus have no influenc...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Kayser W,Hoffmann F

    更新日期:1979-11-01 00:00:00

  • [Intrauterine fetal death in acute toxoplasmosis infection].

    abstract::This is a report on a rare incident of an intrauterine foetal death with toxoplasmosis in the 25th week of pregnancy. The diagnosis could be made serologically as well as pathologically. The issues connected with serological screening for toxoplasmosis are discussed on the basis of this case. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022334

    authors: Lagemann A,Wienegge C

    更新日期:1994-09-01 00:00:00

  • [Diagnosis of holoprosencephaly with cyclopia in the fetus].

    abstract::The typical ultrasound findings in cases of fetal holoprosencephaly with hypotelorism and cyclopia are explained with reference to a case history. Hypotelorism was confirmed by measurement of the distance between the orbits of the fetus. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036239

    authors: Schmidt R,Boos R,Schmidt W

    更新日期:1986-07-01 00:00:00

  • Zika Virus and Pregnancy: Association between Acute Infection and Microcephaly in Newborns in the State of Rio de Janeiro, Brazil.

    abstract::Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with sympt...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0972-2052

    authors: Pereira AM,Araujo Júnior E,Werner H,Monteiro DLM

    更新日期:2020-01-01 00:00:00

  • [Seasonal variations in the incidence of the conception of multiple pregnancies in two centuries (author's transl)].

    abstract::Seasonal variations in the incidence of the conception of multiple pregnancies are compared in the same population area in two centuries. 12,617 singleton and 101 twin pregnancies from 1803 to 1852 are compared to 63,967 singleton, 473 twin and 5 triplet pregnancies from 1965 to 1970. In both groups the percentage dec...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Hoffmann Fr

    更新日期:1978-02-01 00:00:00

  • [Cytobrush quality assurance in endocervical smears].

    abstract::The reliability of cervical cytology for the detection of premalignant and malignant disease is dependent on proper sampling of the transformation zone. The use of a cervical brush to collect enough endocervical cells is more effective, than the use of the conventional cotton swab. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026332

    authors: Kerl J,Ross A,Hilgarth M

    更新日期:1991-01-01 00:00:00

  • [Effect of stress incontinence operations on urodynamic parameters. 1. Is surgical success measurable?].

    abstract::Urodynamic parameters are changed by stress incontinence surgery. Our study, comparing pre- and postoperative measurements in 141 women with urinary stress incontinence, shows an increase of the transmission ratio in the proximal urethra and a decrease of depression factors in the proximal and mid urethra after surger...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036005

    authors: de Gregorio G,Dietz G,Heisterkamp M,Kaltenbach FJ,Hillemanns HG

    更新日期:1988-06-01 00:00:00

  • [The IQ in gynaecology (author's transl)].

    abstract::Relevant correlations between the level of the IQ and the reactions to gynaecological interventions and changes in the female reproductive system were detected. These are important in medical practice. The findings are based on psychometric studies in 400 to 500 women. First: Puberty and menarche are experienced in co...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Wenderlein JM

    更新日期:1978-08-01 00:00:00

  • [Further reproduction after clomiphene-induced pregnancy (author's transl)].

    abstract::The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneo...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Tscherne G

    更新日期:1976-10-01 00:00:00

  • [The value of routine lymphadenectomy in radical Wertheim hysterectomies (author's transl)].

    abstract::In 1959 Rauscher and Spurny questioned the advantages of routine lymphadenectomy in radical Wertheim operations compared to selective lymphadenectomies. Our present review disagrees with the above mentioned doubts. Rauscher and Spurny base their results on clinical staging of cancer of the cervix in cases from 1947 to...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Tulzer H,Kupka S

    更新日期:1976-06-01 00:00:00

  • [Vaginal sonographic contrast imaging of the endometrium with gel].

    abstract::In many cases, the sonography of the endometrium requires an exact pre-therapeutical interpretation. Apart from a hysteroscopy, this can take place by means of an improved version of a contrast hysterosonography, i.e. the Gel-KHSG. The technique and examination results are described here. This simple examination metho...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026180

    authors: Klug PW

    更新日期:1991-06-01 00:00:00