Abstract:
:During the past fifteen years strong evidence has accumulated that particular types of human papilloma viruses are involved in the aetiology of cervical cancer. Early reports suggested that women with cytological signs of papilloma virus infection have a significantly higher risk to develop cervical cancer. Recent studies with sensitive detection methods for viral nucleic acids, however, demonstrated that latent papilloma virus infections are widespread and that only a minor part of infected people will suffer from epithelial lesions that may progress to invasive cancer. The infection per se is apparently not sufficient to induce the malignant phenotype in genital keratinocytes. Detailed molecular analysis of cervical cancer cells revealed that the DNA of the cancer associated papilloma viruses is usually integrated into the cellular genome of the carcinoma cells. Only two viral genes (E6 and E7) are always preserved in a functional active state. The expression of these two genes is deregulated since physiological control mechanisms for viral gene expression are eliminated by the integration process. Artificial introduction of the E6-E7 genes into genital keratinocytes leads to unlimited growth of these cells in tissue culture but does not convert them into the malignant state. Keratinocytes that express the E6-E7 genes resemble in some aspects cells found in premalignant lesions, e.g. the cervical intraepithelial neoplasia (CIN). Thus, the deregulated expression of the papilloma virus E6-E7 genes appears not to be sufficient to evoke cancer. Additional not yet characterized factors must cooperate with the viral E6-E7 genes to transform keratinocytes into the full malignant phenotype.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
von Knebel Doeberitz Msubject
Has Abstractpub_date
1990-07-01 00:00:00pages
511-7issue
7eissn
0016-5751issn
1438-8804journal_volume
50pub_type
杂志文章,评审abstract::Introduction: Use of hormone therapy (HT) has declined dramatically in recent years. Some studies have reported that HT use before a diagnosis of breast cancer (BC) may be a prognostic factor in postmenopausal patients. This study aimed to examine the prognostic relevance of HT use before BC diagnosis. Methods: Four B...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0035-1546149
更新日期:2015-06-01 00:00:00
abstract::All controlled studies which were available by computer search from the literature were evaluated regarding the efficiency of preventive antibiotics for post-operative infections following hysterectomies and Cesarian sections. All controlled studies were evaluated by identical criteria. In 41 out of 46 studies (89.1%)...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036417
更新日期:1984-01-01 00:00:00
abstract::The results of the treatment of 40 vesico-vaginal fistulas, 13 uretero-vesical fistulas, 2 ureto-uterine fistulas are 44 lower ureteral stenosis are reported. These developed following operative and radio-therapeutic treatment in gynaecology and obstetrics. The vesico-vaginal fistulas were operated through the vagine ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-04-01 00:00:00
abstract::Subcutaneous mastectomy was performed in 335 patients between 1974 and 1982. In 265 of these, original mammographies were available which were analysed retrospectively and compared with the final histological finding of the subcutaneous mastectomy preparation. The rate of newly discovered non-invasive carcinomas in th...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036377
更新日期:1985-09-01 00:00:00
abstract::To investigate the accuracy of a single high-speed core biopsy, in 159 stereotactically localised nonpalpable breast lesions a single high-speed core biopsy was performed prior to open surgery. All pathological findings of the specimen, core biopsies and open biopsies, were compared. Two biopsies were technically insu...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022254
更新日期:1996-04-01 00:00:00
abstract:UNLABELLED:Perineal ultrasound was used with a new measurement method that locates the urethrovesical junction. The aim of this study was to test the reproducibility of this examination. Two different investigators examined 40 patients at rest and during Valsalva's manoeuvre. Using a rectangular coordinate system, the ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022317
更新日期:1995-12-01 00:00:00
abstract::In 966 patients who had undergone surgery and who had been suffering from squamous cell carcinoma, tumour recurrence occurred in 16.8% of the cases. In almost 70% of these cases, recurrence was seen in the first two years following treatment. 15% of the patients died of the carcinoma. Compared with the patients who ha...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036554
更新日期:1983-07-01 00:00:00
abstract::A study of the side effects of epidural anesthesia for painless delivery in 100 patients showed that 90% of the post partum patients were very satisfied with the analgesia and did not consider symptoms post partum to be very debilitating and did not blame the epidural anesthesia for the symptoms. Severe pain in the oc...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-2008-1036870
更新日期:1984-03-01 00:00:00
abstract::The use of computers improves data storage capacity and leads to a homogeneous documentation of data obtained. After extensive preparations documentation was started using in 1975 the 2nd Department of Obstetrics and Gynecology computer. The obstetrical-gynecological data base is used for organisational, epidemiologic...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036408
更新日期:1989-05-01 00:00:00
abstract::Recurrence in Four Consecutive Pregnancies in a Patient: We report on the recurrence of HELLP-syndrome in four consecutive pregnancies in a patient. The observation of recurrence of this rare disorder (0.2-0.8% of all pregnancies) in an otherwise healthy patient points to an immunological or genetic predisposition for...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022295
更新日期:1996-09-01 00:00:00
abstract::The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::Diet and exercise before and during pregnancy affect the course of the pregnancy, the child's development and the short- and long-term health of mother and child. The Healthy Start - Young Family Network has updated the recommendations on nutrition in pregnancy that first appeared in 2012 and supplemented them with re...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0713-1058
更新日期:2018-12-01 00:00:00
abstract::The prognostic significance of the lysosomal protease cathepsin D in breast cancer was evaluated in a retrospective study. Cathepsin D was measured in 346 deep-frozen (-70 degrees C) cytosol specimens of primary breast carcinomas (1982-1990). Among the established prognostic factors, only axillary lymph node involveme...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022337
更新日期:1994-10-01 00:00:00
abstract::The foetal outcome was examined in 24 pregnant females with EPH gestosis and a placental weight below the 20th percentile. The results show a high perinatal mortality in such cases. 11 newborns with a mean birth weight of 1092 g and a mean gestational age of 33.8 weeks died perinatally versus 13 newborns with a mean b...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035919
更新日期:1986-05-01 00:00:00
abstract::A case of aplasia of the uterine cervix and partial atresia of the vagina in a 17 year old woman is reported. A hysterectomy was done and a new vagina created. The literature on the origin of the different parts of the female genital tract is reviewed and discussed. Interpretation of the embryologic origin of the diff...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract::Constant and limited (max. 300 g) force of application by the Bamberg divergent forceps helps to prevent compression injuries and slippage of the forceps with resultant trauma. No serious foetal lesions have been observed over a period of 9 years. Maternal soft-tissue injuries were somewhat above the range of vacuum e...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036528
更新日期:1984-12-01 00:00:00
abstract::Approximately one third of all local recurrences of breast cancer are incurable at the time of diagnosis. Locoregional intraarterial chemotherapy is one of the new therapy modalities besides laser therapy and combined radiotherapy/hyperthermia. The results of a phase I-II study, in which 15 patients with advanced, par...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023722
更新日期:1993-11-01 00:00:00
abstract::At the hospital for women in Finkenau intra-uterine devices are used since 1965. At first plastic devices were used exclusively. It was assumed that the devices could stay for variable times. The present opinion that non-commper deivces have to be changed at regular intervals is in contradistinction to our first opini...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract::In 49 carcinomas of the endometrium of varying clinical stages the estrogen and progesterone receptors were studied by charcoal absorption methods. The cases were studied between 1979 and 1981. 64% of the investigated cases were receptor positive, 35% were receptor negative. Estrogen receptors were detected in 61% and...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037179
更新日期:1982-12-01 00:00:00
abstract::After 15 years of clinical experiences with Clomiphen treatment it seemed desirable to investigate the efficiency of this kind of therapy under routine conditions in a crowded out-patient clinic. 314 patients treated from 1972--1974 have been included in this study. From 242 sterility patients 730 cycles could be foll...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::The introduction of percutaneous nephrostomy under xc-ray control or ultra-sonic control makes it possible to do the operation even in patients with a bad general condition. The decision for palliative urinary diversion in cases of cancer of the pelvis is therefore largely an ethical question. A group of patients with...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037150
更新日期:1982-10-01 00:00:00
abstract::The therapy for patients with breast cancer has developed markedly in the past ten years. Our understanding of the molecular biology of tumours and the characteristics of the patients has shaped the recent advances. In this review we present the latest knowledge about the therapy for breast cancer. There are new tests...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0035-1545704
更新日期:2015-02-01 00:00:00
abstract:UNLABELLED:The paper is a review on the actual possibilities and indications of the transplacentar therapy of the fetus. At first some principles of the pharmacodynamics of the materno-placento-fetal unit are explained in order to enable an effective drug administration and reach therapeutic levels in the fetus. Common...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1022783
更新日期:1995-02-01 00:00:00
abstract::Report on a 30-year old primigravida with a family history of bleeding and a personal history of nasopharyngeal bleeding since age four. Severe menorrhagia since her menarche. First seen at 20 weeks gestation with naso-pharyngeal bleeding and a twin pregnancy. The patient was found to have Glanzmann's disease (congeni...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract::The importance of yeast infections in obstetrics was investigated in 200 pregnant women and their newborns. In the maternity patients the vagina was tested shortly before the delivery and the mouth of the neonates was tested 1 day prior to the discharge from the hospital. In 22% of the pregnant women and in 8,4% of th...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::The ovarian carcinoma-associated antigen CA-125 was determined in 144 women with various gynecological tumors (ovarian, breast, uterine), by using the heterologous monoclonal antibody OC-125. In 90% of the malignant ovarian tumors positive CA-125 values were correct, whereas their negative values were correct in 88% o...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036133
更新日期:1985-11-01 00:00:00
abstract::In July 2012 a revised terminology on colposcopic examinations of the cervix uteri was adopted by IFCPC. Central aspect is a description of characteristics that should aid in the definition of the disease entity cervix uteri. The nomenclature is built up in such a way that the examiner can evaluate colposcopic criteri...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0033-1350824
更新日期:2013-09-01 00:00:00
abstract::The authors report on five cases of massive atonic uterine haemorrhage which could be influenced neither by repeated application of oxytocin nor by methylergometrin. Intramyometrial application of PGF2 alpha succeeded in inducing a satisfactory uterine tone and stopping the haemorrhage. With regard to own experiences ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026501
更新日期:1988-04-01 00:00:00
abstract::In a total of 4149 prenatal patients there were 849 patients who became pregnant following the cessation of the use of oral contraceptives. Results were compared with pregnancies of a similar series of 1000 patients who never had employed contraceptive steroids. Comparison shows a lower incidence of abortion of 5,6% i...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Leiomyomatosis peritonealis disseminata (LPD) is a rare benign disease characterised by the presence of multiple intraabdominal nodules, consisting of benign smooth muscle. LPD has only been found in women, predominantly in their late reproductive age. There is a very high association with excess exogenous and endogen...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023578
更新日期:1994-03-01 00:00:00