Abstract:
:Introduction Aim of the study was to evaluate the association between microcephaly and acute infection with Zika virus (ZIKV) in pregnant women in the state of Rio de Janeiro, Brazil. Infection was confirmed by laboratory testing. Materials and Methods A cross-sectional retrospective study of pregnant women with symptoms occurring between 2015 and 2016 suggestive of acute ZIKV infection was carried out, with confirmation of infection done by blood or urine RT-PCR. The relative proportions of categorical variables were calculated for two distinct groups: pregnant women whose newborns had microcephaly and pregnant women who gave birth to infants without microcephaly. Confidence intervals with a 95% level of agreement were estimated for the relative ratios. Results A total of 1609 pregnant women with a mean age of 26.4 ± 6.5 years were evaluated. As regards the time of acute infection, 19.6% (316) of cases occurred in the first trimester of pregnancy. Nineteen (76%) of the 25 cases with microcephaly (1.5%) were associated with an infection contracted in the first trimester of pregnancy (p < 0.001, OR = 13.7, 95% CI: 5.6 - 37.7). 48% (12/25) of the newborns with microcephaly had a birth weight of < 2500 grams, while only 7% (116/1597) of the group of newborns without microcephaly had a similarly low birth weight (p < 0.001, OR = 11.7, 95% CI: 5.2 - 26.2). Logistic regression showed that a birth weight of < 2500 g (OR = 12.54) and ZIKV infection in the first trimester of pregnancy (OR = 14.05) were associated with microcephaly (area under ROC curve = 0.86). Conclusion Acute ZIKV infection in the first trimester of pregnancy and low birth weight are associated with microcephaly. :Einleitung Ziel dieser Studie war es, die Assoziation zwischen Mikrozephalie und akuter Infektion mit Zikavirus (ZIKV) bei schwangeren Frauen im Bundesstaat Rio de Janeiro, Brasilien zu untersuchen. Die Infektion wurde durch Laboruntersuchungen bestätigt. Material und Methoden Es wurde eine retrospektive Querschnittsstudie von schwangeren Frauen mit Symptomen, die zwichen 2015 und 2016 auftraten und die auf eine Infektion mit ZIKV hindeuteten, durchgeführt. Die Infektion wurde mittels RT-PCR von Blut- bzw. Urinproben bestätigt. Die relativen Anteile der kategorischen Variablen wurden für 2 verschiedenen Gruppen kalkuliert: schwangere Frauen, die Neugeborene mit Mikrozephalie zur Welt brachten, und schwangere Frauen, deren Kinder keine Mikrozephalie aufwiesen. Die 95%-Konfidenzintervalle für die relativen Anteile wurden geschätzt. Ergebnisse Insgesamt wurden 1609 schwangere Frauen mit einem Durchschnittsalter von 26,4 ± 6,5 Jahren evaluiert. Was den Zeitpunkt der akuten Infektion angeht, stellte sich heraus, dass 19,6% (316) der Infektionen im 1. Schwangerschaftstrimenon aufgetreten waren. Bei 25 Fällen mit Mikrozephalie (1,5%) bestand bei 19 (76%) eine Assoziation mit einer Ansteckung im 1. Trimester der Schwangerschaft (p < 0,001; OR = 13,7; 95%-KI [5,6 – 37,7]). Von den Neugeborenen mit Mikrozephalie hatten 48% (12/25) ein Geburtsgewicht von < 2500 g, wohingegen nur 7% (116/1597) der Neugeborenen in der Gruppe ohne Mikrozephalie ein ähnlich niedriges Geburtsgewicht aufwiesen (p < 0,001; OR = 11,7; 95%-KI [5,2 – 26,2]). Das logistische Regressionsmodell zeigte, dass ein Geburtsgewicht von < 2500 g (OR = 12,54) sowie eine ZIKV-Infektion im 1. Trimenon der Schwangerschaft (OR = 14,05) mit Mikrozephalie assoziiert sind (Fläche unter der ROC-Kurve = 0,86). Schlussfolgerung Akute Infektion mit ZIKV im 1. Schwangerschaftstrimester und ein niedriges Geburtsgewicht sind mit dem Auftreten von Mikrozephalie assoziiert.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Pereira AM,Araujo Júnior E,Werner H,Monteiro DLMdoi
10.1055/a-0972-2052subject
Has Abstractpub_date
2020-01-01 00:00:00pages
60-65issue
1eissn
0016-5751issn
1438-8804pii
9722052journal_volume
80pub_type
杂志文章abstract::Clinical data on 607 patients with invasive squamous cell carcinoma of the vulva seen between 1952-1980 are reported. All of these patients were eligible for 5-year evaluation. The crude survival for these patients was 60.3%, and the cleaned 5-year survival for 530 patients was 69% (stage I [n = 158]: 87.3%, stage II ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036264
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abstract::Malignant tumours can be differentiated from the benign ones by their vascular blood supply. We employed three methods to analyse the blood flow: the angiodynograph, the duplex system, and the continuous-wave Doppler method, and measured the blood flow in 151 patients on the preoperative day. Histology revealed a mali...
journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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abstract::Tuberculosis in a case of non-puerperal mastitis is a rare clinical finding. A special case of a 28-year old Thai patient was diagnosed and successfully treated with an antituberculous chemotherapy. The most important diagnostic procedure was the microbiological and histological investigation to enable the diagnosis t...
journal_title:Geburtshilfe und Frauenheilkunde
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abstract::In a retrospective study the mode of delivery by 565 pregnant women who had previously undergone Caesarean section, was explored on the basis of their medical records. Particular attention was paid to the problem of PDA. Primary Caesarean section was performed in about 25% of the cases and secondary Caesarean section ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036868
更新日期:1984-03-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
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更新日期:1994-12-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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doi:10.1055/s-2008-1039533
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023326
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1022818
更新日期:1995-08-01 00:00:00
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journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 临床试验,杂志文章
doi:
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