Histologic evolution of radiofrequency lesions in an old human myocardial infarct causing ventricular tachycardia.

Abstract:

INTRODUCTION:Radiofrequency (RF) ablation of ventricular tachycardia (VT) late after myocardial infarction may be difficult due to characteristics of the infarct containing the reentry circuit. RF lesions in these infarcts in humans have not been characterized. METHODS AND RESULTS:Catheter mapping and ablation of VT originating from an anterior wall infarct was performed 8 days and again 12 hours prior to death. Pacing identified a region of abnormal conduction where RF ablation terminated VT. This region contained strips of myocytes sandwiched between endocardial fibrosis and dense scar. RF lesions ranged from 2 x 2 mm to 5 x 10 mm and were up to 3 mm in depth. Acute lesions showed superficial thrombus and early coagulation necrosis without inflammation. Older lesions showed coagulation necrosis, sparse neutrophil infiltrate, minimal granulation tissue, hemorrhage, and mixed inflammatory infiltrate along the lumen without re-endothelialization. CONCLUSION:In this patient, RF lesions had sufficient depth but not width to interrupt the thin, but potentially broad, sheets of myocytes in the reentry circuit. In thinned areas, RF lesions can extend to the epicardium. Selecting sites with abnormal electrograms confines RF lesions to the infarct region. Inflammation and hemorrhage could conceivably cause delayed effects of RF.

authors

Bartlett TG,Mitchell R,Friedman PL,Stevenson WG

doi

10.1111/j.1540-8167.1995.tb00439.x

subject

Has Abstract

pub_date

1995-08-01 00:00:00

pages

625-9

issue

8

eissn

1045-3873

issn

1540-8167

journal_volume

6

pub_type

杂志文章
  • Sudden death in the community.

    abstract::About one fifth of all deaths occur suddenly and unexpectedly, often as the first manifestation of heart disease. Several tests have been developed during the past 2 decades for risk stratification of such an event, but only a minority of victims can be identified as being at high risk before sudden death occurs. Impr...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.14.ss9.1.x

    authors: Wellens HJ,Gorgels AP,de Munter H

    更新日期:2003-09-01 00:00:00

  • EP radiofrequency generators: Significant offsets between selected and delivered power?

    abstract:INTRODUCTION:For radiofrequency (RF) ablation, the EP Shuttle® (Stockert GmbH, Freiburg, Germany), Ampere® (St. Jude Medical, St. Paul, MN, USA), and SmartAblate® (Biosense Webster, Diamond Bar, CA, USA) generator models are most frequently used in clinical practice. The aim of this study was to assess the correlation ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.13386

    authors: Bourier F,Schwarz B,Brkic A,Wolff L,Semmler V,Kottmaier M,Risse E,Telishevska M,Brooks S,Lengauer S,Kornmayer M,Koch-Büttner K,Berger F,Hessling G,Deisenhofer I,Reents T

    更新日期:2018-02-01 00:00:00

  • Heart rate and heart rate variability in normal young adults.

    abstract:INTRODUCTION:The relationships between heart rate (HR) and HR variability (HRV) are not simple. Because both depend on the autonomic nervous system (ANS), they are not independent variables. Technically, the quantification of HRV is influenced by the duration of the cardiac cycles. The complexity of these relationships...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1994.tb01130.x

    authors: Coumel P,Maison-Blanche P,Catuli D

    更新日期:1994-11-01 00:00:00

  • Excessive charge time delaying ventricular tachycardia therapy.

    abstract::A 70-year-old man with a single-chamber implantable cardioverter defibrillator (ICD) placed for ventricular tachycardia presented with syncope. He was found to have ventricular flutter/fibrillation with capacitor charge time in excess of 1 minute before defibrillation. The excessive charge time was secondary to ICD ca...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2001.01078.x

    authors: Panchal VR,Groh WJ

    更新日期:2001-09-01 00:00:00

  • Cardiac electrophysiology in genetically engineered mice.

    abstract::The mouse has become the principal animal model for studying biologic processes in mammals. Major advances in transgene and gene targeting technology enabled manipulation of the mouse genome in a predictable fashion. Mutant mouse strains provide important insights into the molecular mechanisms underlying normal and di...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1540-8167.2000.tb01806.x

    authors: Gehrmann J,Berul CI

    更新日期:2000-03-01 00:00:00

  • Spontaneous and adenosine-induced pulmonary vein reconnection after cryoballoon ablation with the second-generation device.

    abstract:INTRODUCTION:Longer observational time and adenosine challenge have proven to be able to detect pulmonary vein (PV) reconnections. The aim of this study was to assess incidence of spontaneous and adenosine-induced PV reconnection after ablation with second-generation cryoballoon (CB-Adv). METHODS AND RESULTS:Fifty con...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12421

    authors: Ciconte G,Chierchia GB,DE Asmundis C,Sieira J,Conte G,Juliá J,DI Giovanni G,Wauters K,Baltogiannis G,Saitoh Y,Mugnai G,Catanzariti D,Tondo C,Brugada P

    更新日期:2014-08-01 00:00:00

  • Epicardial sock mapping following monophasic and biphasic shocks of equal voltage with an endocardial lead system.

    abstract:INTRODUCTION:The reason for the increased defibrillation efficacy of biphasic shocks over monophasic shock is not definitely known. METHODS AND RESULTS:In six anesthetized pigs, we mapped the epicardium after transvenous defibrillation shocks to compare the activation patterns following successful biphasic shocks with...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1996.tb00533.x

    authors: Usui M,Callihan RL,Walker RG,Walcott GP,Rollins DL,Wolf PD,Smith WM,Ideker RE

    更新日期:1996-04-01 00:00:00

  • Catheter ablation of frequently recurring ventricular fibrillation in a patient after aortic valve repair.

    abstract::It has been demonstrated that idiopathic ventricular fibrillation (VF) can be triggered by ventricular premature beats (VPBs) arising from the Purkinje fibers. Eliminating these VPBs by radiofrequency catheter ablation prevented VF recurrences. Whether the same pathophysiology and the same treatment option exist in pa...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1046/j.1540-8167.2004.03386.x

    authors: Li YG,Grönefeld G,Israel C,Hohnloser SH

    更新日期:2004-01-01 00:00:00

  • Gender and seasonally related differences in myocardial recovery and susceptibility to sotalol-induced arrhythmias in isolated rabbit hearts.

    abstract:INTRODUCTION:Gender differences and seasonal variations in cardiac electrophysiology and susceptibility to arrhythmias have been described clinically. The present study was undertaken to determine if there are similar gender and seasonally related differences in the electrophysiology of the rabbit heart. METHODS AND R...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2000.tb00067.x

    authors: Spear JF,Moore EN

    更新日期:2000-08-01 00:00:00

  • Distortion of right superior pulmonary vein anatomy by balloon catheters as a contributor to phrenic nerve injury.

    abstract:INTRODUCTION:Cryothermal, HIFU, and laser catheter-based balloon technologies have been developed to simplify ablation for AF. Initial enthusiasm for their widespread use has been dampened by phrenic nerve (PN) injury. The interaction between PN and pulmonary vein (PV) geometry contributing to PN injury is unclear. ME...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2009.01495.x

    authors: Okumura Y,Henz BD,Bunch TJ,Dalegrave C,Johnson SB,Packer DL

    更新日期:2009-10-01 00:00:00

  • Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death.

    abstract:INTRODUCTION:Recent studies have implicated repolarization lability in the genesis of malignant ventricular arrhythmias. However, few data exist on assessment of temporal QT interval variability and its relation to arrhythmogenesis. We tested the ability of the QT variability index (QTVI), a measure of beat-to-beat QT ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1998.tb00130.x

    authors: Atiga WL,Calkins H,Lawrence JH,Tomaselli GF,Smith JM,Berger RD

    更新日期:1998-09-01 00:00:00

  • Regional isolation in the right atrium with disruption of intra-atrial conduction after catheter ablation of atrial tachycardia.

    abstract:BACKGROUND:Ablation of atrial tachycardia (AT) that occurs after cardiac surgery or prior ablation often requires complex lesion sets. In combination with the pre-existing atrial scar, these lesion sets may result in inadvertent intra-atrial conduction block. This study reports the phenomenon of incidental isolation of...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14037

    authors: Markowitz SM,Choi DY,Daian F,Liu CF,Cheung JW,Thomas G,Ip JE,Lerman BB

    更新日期:2019-10-01 00:00:00

  • 3D cardiovascular navigation system: accuracy and reduction in radiation exposure in left ventricular lead implant.

    abstract:INTRODUCTION:Cardiac resynchronization therapy implants entail significant radiation exposure for patients and physicians. A novel 3D electromagnetic cardiovascular navigation system (MediGuide™) was designed to superimpose the real-time location of sensors embedded in delivery tools on prerecorded coronary sinus (CS) ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12290

    authors: Valderrabano M,Greenberg S,Razavi H,More R,Ryu K,Heist EK

    更新日期:2014-01-01 00:00:00

  • A regular wide QRS complex tachycardia: What is the mechanism?

    abstract::A 14-year-old girl with a history of recurrent palpitations and documented wide QRS complex tachycardia was referred for electrophysiologic study and catheter ablation. ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type:

    doi:10.1111/jce.13905

    authors: Arias MA,Puchol A,Pachón M,Martín-Sierra C

    更新日期:2019-07-01 00:00:00

  • A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: the DIONYSOS study.

    abstract:INTRODUCTION:We compared the efficacy and safety of amiodarone and dronedarone in patients with persistent atrial fibrillation (AF). METHODS:Five hundred and four amiodarone-naïve patients were randomized to receive dronedarone 400 mg bid (n = 249) or amiodarone 600 mg qd for 28 days then 200 mg qd (n = 255) for at le...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1540-8167.2010.01764.x

    authors: Le Heuzey JY,De Ferrari GM,Radzik D,Santini M,Zhu J,Davy JM

    更新日期:2010-06-01 00:00:00

  • Comparison between minimal fluoroscopy and conventional approaches for visually guided laser balloon pulmonary vein isolation ablation.

    abstract:INTRODUCTION:Although balloon-based techniques, such as the laser balloon (LB) ablation have simplified pulmonary vein isolation (PVI), procedural fluoroscopy usage remains higher in comparison to radiofrequency PVI approaches due to limited 3-dimensional mapping system integration. METHODS:In this prospective study, ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14546

    authors: Huang HD,Rodriguez JM,Serafini NJ,Macias C,Winterfield J,Sharma PS,Larsen T,Krishnan K,Trohman RG

    更新日期:2020-07-01 00:00:00

  • Avoid delivering therapies for nonsustained fast ventricular tachyarrhythmia in patients with implantable cardioverter/defibrillator: the ADVANCE III Trial.

    abstract:INTRODUCTION:The purpose of this investigation is to evaluate whether a prolonged detection interval for life threatening ventricular tachyarrhythmia (VT) is able to reduce therapies (Rx) delivered by an implantable cardioverter/defibrillator (ICD). Until now, only the PREPARE trial demonstrated a reduction of ICD Rx i...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1540-8167.2008.01415.x

    authors: Schwab JO,Gasparini M,Lunati M,Proclemer A,Kaup B,Santi E,Ligorio G,Klersy C,DE Sousa J,Okreglicki A,Arenal A,Wijffels M,Lemke B

    更新日期:2009-06-01 00:00:00

  • Irregular sinus parasystole due to intermittency and modulation of parasystolic activity.

    abstract::A case of intermittent sinus parasystole in which the parasystolic focus is protected from the dominant sinus rhythm only during the second half of its intrinsic cycle is reported. In addition, a modulating (i.e., electronic) effect is often clearly exerted from the dominant rhythm upon the focus during the protected ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1996.tb00523.x

    authors: Satullo G,Donato A,Busá G,Cavallaro L

    更新日期:1996-03-01 00:00:00

  • Complex fractionated atrial electrograms related to left atrial wall thickness.

    abstract:INTRODUCTION:The mechanism of complex fractionated atrial electrogram (CFAE) in patients with atrial fibrillation (AF) remains controversial. This study investigated the relationship between CFAE and left atrial (LA) wall thickness. METHODS AND RESULTS:LA muscular wall thickness (excluding fat) was measured by cardiac...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12473

    authors: Wi J,Lee HJ,Uhm JS,Kim JY,Pak HN,Lee M,Kim YJ,Joung B

    更新日期:2014-11-01 00:00:00

  • Effects of Age-Related Aortic Root Anatomic Changes on Left Ventricular Outflow Tract Pace-Mapping Morphologies: A Cardiac Magnetic Resonance Imaging Validation Study.

    abstract:INTRODUCTION:Outflow tract ventricular arrhythmias (OT VAs) are common and catheter ablation is an effective treatment option. We sought to investigate the relationship between age-related anatomic aortic root changes and QRS morphology during left ventricular outflow tract (LVOT) pace-mapping using cardiac magnetic re...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.12712

    authors: Maeda S,Chik WW,Han Y,Liang JJ,Squara F,Arkles JS,Sadek MM,Santangeli P,Frankel DS,Zado ES,Takebayashi S,Dixit S,Callans DJ,Marchlinski FE,Lin D

    更新日期:2015-09-01 00:00:00

  • Sequential His bundle and left ventricular pacing for cardiac resynchronization.

    abstract:INTRODUCTION:Fusion of left ventricular pacing with intrinsic conduction provides superior resynchronization compared to biventricular pacing. His bundle pacing (HBP) preserves intrinsic conduction and allows for constant fusion with left ventricular pacing. This study evaluated sequential His bundle and left ventricul...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14674

    authors: Deshmukh A,Sattur S,Bechtol T,Heckman LIB,Prinzen FW,Deshmukh P

    更新日期:2020-09-01 00:00:00

  • Magnetic navigation in left-sided AV reentrant tachycardias: preliminary results of a retrograde approach.

    abstract:INTRODUCTION:A novel magnetic navigation system allows remote guidance of floppy radiofrequency (RF) ablation catheters. We evaluated the feasibility of mapping and ablation of left-sided accessory pathways (APs) using the retrograde transaortic approach with this system. This might open the gate to retrograde ablation...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1540-8167.2007.00783.x

    authors: Thornton AS,Rivero-Ayerza M,Knops P,Jordaens LJ

    更新日期:2007-05-01 00:00:00

  • Differential effect of adenosine on anterograde and retrograde fast pathway conduction in patients with atrioventricular nodal reentrant tachycardia.

    abstract:INTRODUCTION:Several studies have shown that the fast pathway is more responsive to adenosine than the slow pathway in patients with AV nodal reentrant tachycardia. Little information is available regarding the effect of adenosine on anterograde and retrograde fast pathway conduction. METHODS AND RESULTS:The effects o...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.1998.tb00121.x

    authors: Souza JJ,Zivin A,Flemming M,Pelosi F,Oral H,Knight BP,Goyal R,Man KC,Strickberger SA,Morady F

    更新日期:1998-08-01 00:00:00

  • Failure of cilostazol in the prevention of ventricular fibrillation in a patient with Brugada syndrome.

    abstract::The ECG appearance in Brugada syndrome is caused by failure of the dome of the action potential to develop. Increased activity of the I(to) current in epicardial cells generates a transmural gradient with repolarization dispersion between the epicardium and the endocardium in the right ventricular wall, thus favoring ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2005.00290.x

    authors: Abud A,Bagattin D,Goyeneche R,Becker C

    更新日期:2006-02-01 00:00:00

  • In vivo effects of mutant HERG K+ channel inhibition by disopyramide in patients with a short QT-1 syndrome: a pilot study.

    abstract:INTRODUCTION:Quinidine has been evaluated in patients with a short QT-1 syndrome caused by an IKr gain-of-function mutation of HERG. Recently, in vitro data with disopyramide showed an even stronger effect on the N588K mutant current. The aim of the present study was to test the in vivo effects of disopyramide in patie...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2007.00925.x

    authors: Schimpf R,Veltmann C,Giustetto C,Gaita F,Borggrefe M,Wolpert C

    更新日期:2007-11-01 00:00:00

  • Catheter ablation of common-type atrial flutter guided by three-dimensional right atrial geometry reconstruction and catheter tracking using cutaneous patches: a randomized prospective study.

    abstract:INTRODUCTION:EnSite NavX (NavX) is a novel mapping and navigation system that allows visualization of conventional catheters for diagnostic and ablative purposes and uses them to create a three-dimensional (3D) geometry of the heart. NavX is particularly suitable for ablation procedures utilizing an anatomic approach, ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1540-8167.2004.04064.x

    authors: Ventura R,Rostock T,Klemm HU,Lutomsky B,Demir C,Weiss C,Meinertz T,Willems S

    更新日期:2004-10-01 00:00:00

  • Long-term efficacy and safety of two different rhythm control strategies in elderly patients with symptomatic persistent atrial fibrillation.

    abstract:BACKGROUND:We prospectively compared the efficacy, safety, and quality of life (QoL) impact of catheter ablation versus antiarrhythmic drugs (AAD) in elderly patients with persistent atrial fibrillation (AF). METHODS AND RESULTS:Four hundred and twelve consecutive patients, aged ≥ 70 years, underwent ablation (Group A...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 临床试验,杂志文章

    doi:10.1111/jce.12126

    authors: Blandino A,Toso E,Scaglione M,Anselmino M,Ferraris F,Sardi D,Battaglia A,Gaita F

    更新日期:2013-07-01 00:00:00

  • Cardiovascular biomarkers and echocardiographic findings at rest and during graded hypovolemic stress in women with recurrent vasovagal syncope.

    abstract:INTRODUCTION:Vasovagal reflex is the most common type of syncope but its etiology is not fully elucidated. Venous return and cardiac output are key in hemodynamic control. The aim of the study was to assess cardiovascular biomarkers and echocardiographic measures at rest and during hypovolemia in women with and without...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/jce.14207

    authors: Lindenberger M,Fedorowski A,Melander O,Gallo W,Engvall J,Skoog J

    更新日期:2019-12-01 00:00:00

  • Thromboembolic events and need for anticoagulation therapy following left atrial appendage occlusion in patients with electrical isolation of the appendage.

    abstract:INTRODUCTION:Electrical isolation of the left atrial appendage (LAA) is an important adjunctive ablation strategy in patients with nonparoxysmal atrial fibrillation (AF). Patients who have impaired LAA contractility following isolation may require long-term oral anticoagulant (OAC) therapy irrespective of their CHADS2 ...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jce.13838

    authors: Gadiyaram VK,Mohanty S,Gianni C,Trivedi C,Al-Ahmad A,Burkhardt DJ,Gallinghouse JG,Hranitzky PM,Horton RP,Sanchez JE,Della Rocca DG,Di Biase L,Price MJ,Couts L,Gibson D,Natale A

    更新日期:2019-04-01 00:00:00

  • Autonomic elements within the ligament of Marshall and inferior left ganglionated plexus mediate functions of the atrial neural network.

    abstract:OBJECTIVES:We sought to systematically investigate the role of the ligament of Marshall (LOM) and inferior left ganglionated plexi (ILGP) in modulating electrophysiological functions. METHODS:The following structures were exposed in 36 dogs: (1) LOM, (2) superior left GP (SLGP) near the junction of left superior pulmo...

    journal_title:Journal of cardiovascular electrophysiology

    pub_type: 杂志文章

    doi:10.1111/j.1540-8167.2008.01315.x

    authors: Lin J,Scherlag BJ,Niu G,Lu Z,Patterson E,Liu S,Lazzara R,Jackman WM,Po SS

    更新日期:2009-03-01 00:00:00