Failure of cilostazol in the prevention of ventricular fibrillation in a patient with Brugada syndrome.

Abstract:

:The ECG appearance in Brugada syndrome is caused by failure of the dome of the action potential to develop. Increased activity of the I(to) current in epicardial cells generates a transmural gradient with repolarization dispersion between the epicardium and the endocardium in the right ventricular wall, thus favoring the development of VF by a phase 2 reentry mechanism. The efficacy of cilostazol for the management of these arrhythmias has been reported. This drug is a phosphodiesterase inhibitor with positive chronotropic properties, thus blocking outward potassium currents I(to) in the myocardial tissue. We present a patient with Brugada syndrome with an implantable cardioverter defibrillator (ICD), who suffered multiple ICD discharges due to VF during therapy with this drug.

authors

Abud A,Bagattin D,Goyeneche R,Becker C

doi

10.1111/j.1540-8167.2005.00290.x

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

210-2

issue

2

eissn

1045-3873

issn

1540-8167

pii

JCE290

journal_volume

17

pub_type

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