Avoid delivering therapies for nonsustained fast ventricular tachyarrhythmia in patients with implantable cardioverter/defibrillator: the ADVANCE III Trial.

Abstract:

INTRODUCTION:The purpose of this investigation is to evaluate whether a prolonged detection interval for life threatening ventricular tachyarrhythmia (VT) is able to reduce therapies (Rx) delivered by an implantable cardioverter/defibrillator (ICD). Until now, only the PREPARE trial demonstrated a reduction of ICD Rx in a cohort of primary prevention patients. METHODS AND RESULTS:The ADVANCE III study is a prospective, randomized, parallel trial with 2 arms evaluating different intervals to detect (NID), i.e., 18/24 (as currently used) versus 30/40. The primary endpoint is to demonstrate a 20% reduction of ICD Rx (antitachycardia pacing or shocks) delivered to terminate spontaneous VT with a cycle length < or =320 ms in patients with Class I-IIA indication for ICD therapy, regardless of cardiac resynchronization capabilities. The worldwide investigation started in spring 2008 and is expected to be finished in 2011. CONCLUSIONS:The ADVANCE III trial is the first randomized investigation evaluating the reduction of ICD Rx for fast VT due to a prolongation of NID in a general ICD patient cohort.

authors

Schwab JO,Gasparini M,Lunati M,Proclemer A,Kaup B,Santi E,Ligorio G,Klersy C,DE Sousa J,Okreglicki A,Arenal A,Wijffels M,Lemke B

doi

10.1111/j.1540-8167.2008.01415.x

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

663-6

issue

6

eissn

1045-3873

issn

1540-8167

pii

JCE1415

journal_volume

20

pub_type

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