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Are the molten globule and the unfolded states of apo-alpha-lactalbumin enthalpically equivalent?

Abstract：

:Recently, the absence of a thermally induced transition has been offered as proof that the unfolded and the molten globule states of apo-alpha-lactalbumin are enthalpically equivalent. In this paper we demonstrate that that argument is thermodynamically incorrect. In addition, it is shown that the absence of a thermally induced transition at extremely low salt concentrations can be accounted for in terms of the known ionic strength dependence of the transition temperature and the thermodynamic parameters associated with the unfolding of apo-alpha-lactalbumin.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

Xie D,Bhakuni V,Freire E

doi

10.1006/jmbi.1993.1364

subject

Has Abstract

pub_date

1993-07-05 00:00:00

pages

5-8

issue

1

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(83)71364-1

journal_volume

232

pub_type

杂志文章

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