Abstract:
:We have recently established that several mRNAs encode the PR264/SC35 splicing factor and that their expression is related to that of c-Myb in human hematopoietic cells. We now report that the various PR264 mRNAs whose expression is transactivated by c-Myb proteins encode an identical PR264/SC35 polypeptide. These mRNAs differ only in their 3' untranslated sequences and exhibit significantly different half-lives. We also show that there is a direct correlation between the length of the 3' untranslated region and the stability of the mRNA species. Given that 5' and 3' splice site selection mediated by the PR264/SC35 splicing factor is concentration-dependent, we postulate that alternative splicing of the 3' untranslated sequences might represent another key element in regulating the levels of PR264/SC35 expression during hematopoietic differentiation.
journal_name
Proc Natl Acad Sci U S Aauthors
Sureau A,Perbal Bdoi
10.1073/pnas.91.3.932subject
Has Abstractpub_date
1994-02-01 00:00:00pages
932-6issue
3eissn
0027-8424issn
1091-6490journal_volume
91pub_type
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