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Efficacy of meclofenamate sodium (Meclomen) in the treatment of rapidly progressive periodontitis.

Abstract：

:This 6-month, double-blind, controlled clinical trial determined the efficacy of the non-steroidal anti-inflammatory drug, meclofenamate sodium (Meclomen), as an adjunct to scaling and root planing in the treatment of rapidly progressive periodontitis (RPP). 22 subjects (7 male, 15 female) aged 36.5 +/- 7.88 years with RPP and disease-active sites as determined by pretreatment bone scan had standardized radiographs at baseline and 6 months, and clinical measurements at baseline, 3 and 6 months. Following full-mouth scaling and root planing, subjects were randomly assigned to either a placebo, 50 or 100 mg meclofenamate sodium bid group. Bone change over the 6-month period as assessed by subtraction radiography was the primary efficacy determinant. Specialized software was used to isolate the lesion from the subtraction image and to measure bone change along the root surface. ANOVA using the subject as the unit of analysis revealed a significant dose response (p < 0.001) with the placebo group having a mean bone loss of 0.42 +/- 0.06 mm and the low and high dose groups having mean bone gains of 0.07 +/- 0.05 and 0.20 +/- 0.07 mm, respectively. These findings indicate that meclofenamate sodium may be a useful adjunct in the treatment of rapidly progressive periodontitis.

journal_name

J Clin Periodontol

journal_title

Journal of clinical periodontology

authors

Reddy MS,Palcanis KG,Barnett ML,Haigh S,Charles CH,Jeffcoat MK

doi

10.1111/j.1600-051x.1993.tb00708.x

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

635-40

issue

9

eissn

0303-6979

issn

1600-051X

journal_volume

20

pub_type

临床试验,杂志文章,随机对照试验

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