Nutrition, endothelial cell metabolism, and atherosclerosis.

Abstract:

:The vascular endothelium that forms an interface between the blood and the surrounding tissues is continuously exposed to both physiologic and pathophysiologic stimuli. These stimuli are often mediated by nutrients that can contribute to the overall function of the endothelial cell in the regulation of vascular tone, coagulation and fibrinolysis, cellular growth and differentiation, and immune and inflammatory responses. Therefore, nutrient-mediated functional changes of the endothelium and the underlying tissues may be significantly involved in the atherosclerotic disease process. There is evidence that individual nutrients or nutrient derivatives may either provoke or prevent metabolic and physiologic perturbations of the vascular endothelium. Preservation of nutrients that exhibit antiatherogenic properties may, therefore, be a critical issue in the preparation and processing of foods. This review focuses on selected nutrients as they affect endothelial cell metabolism and their possible implications in atherosclerosis.

journal_name

Crit Rev Food Sci Nutr

authors

Hennig B,Toborek M,Cader AA,Decker EA

doi

10.1080/10408399409527663

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

253-82

issue

3

eissn

1040-8398

issn

1549-7852

journal_volume

34

pub_type

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