Autologous transplantation of the cervical sympathetic ganglion into the parkinsonian brain: case report.

Abstract:

:The authors have reported a clinical trial of an autologous cervical sympathetic ganglion transplanted into the brain of a parkinsonian patient. A 45-year-old woman presented with bradykinesia and a gait disturbance for 8 years under L-dopa treatment. The patient underwent stereotactic transplantation of the right stellate ganglion into the right putamen. She showed marked amelioration of bradykinesia and gait disturbance 1 month after the operation, and she was able to conduct her activities of daily living without requiring L-dopa administration. The patient continued to improve gradually until 3 months after the operation. Two years after surgery, the patient functions independently as a housewife. The right hand tremor, however, became slightly worse after the operation, but it was transient. The patient developed a permanent right-sided Horner's syndrome after resection of the cervical sympathetic ganglion. Taken together with our previous data obtained from animal experiments, this case suggests that the autologous cervical sympathetic ganglion can be donor tissue for neural transplantation in Parkinson's disease.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Itakura T,Komai N,Ryujin Y,Ooiwa Y,Nakai M,Yasui M

doi

10.1227/00006123-199407000-00026

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

155-7; discussion 157-8

issue

1

eissn

0148-396X

issn

1524-4040

journal_volume

35

pub_type

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