Changes in immunoglobulin levels in zinc-deficient mice infected with Trypanosoma musculi.

Abstract:

:A metabolic imbalance technique was used to study the effects of zinc deficiency on immunoglobulin levels in mice infected with Trypanosoma musculi or immunized with parasite products. Zinc-deficient mice developed higher numbers of parasitemia earlier and exhibited prolonged infection. Irrespective of the diet, higher IgG1, IgG2b, and IgM levels, lower IgG2a and IgA levels, and uniform IgG3 levels were exhibited primarily by mice infected with T musculi and to a lesser extent by mice immunized with parasite products. Zinc-deficient mice showed smaller increases in IgG1 and IgM, but larger gains in IgG2b compared with mice on full-complement and pair-fed diets. However, IgG2a decreased significantly in zinc-deficient mice.

journal_name

J Natl Med Assoc

authors

Humphrey PA,Lee CM,Ashraf M

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

613-9

issue

8

eissn

0027-9684

issn

1943-4693

journal_volume

86

pub_type

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