Improvement in VA/Q distributions during inhalation of nitric oxide in pigs with methacholine-induced bronchoconstriction.

abstract：:Platelets are an important, albeit generally underappreciated, component of the inflammatory cascade. Platelets are known to contribute to inflammation in atherosclerosis, stroke, and asthma. They produce a large number of proinflammatory lipid mediators and cytokines, and play a vital role in recruitment of leukocyte...

journal_title：American journal of respiratory and critical care medicine

authors： O'Sullivan BP,Michelson AD

更新日期：2006-03-01 00:00:00

abstract：RATIONALE:Constitutive activation of the epidermal growth factor receptor (EGFR) is prevalent in epithelial cancers, particularly in non-small cell lung carcinoma (NSCLC). Mutations identified in EGFR predict the sensitivity to EGFR-targeted therapy. Detection of these mutations is mainly based on tissue biopsy, which ...

journal_title：American journal of respiratory and critical care medicine

authors： Wei F,Lin CC,Joon A,Feng Z,Troche G,Lira ME,Chia D,Mao M,Ho CL,Su WC,Wong DT

更新日期：2014-11-15 00:00:00

abstract：RATIONALE:The immune response in sepsis is characterized by overt immune dysfunction. Studies indicate immunostimulation represents a viable therapy for patients. One study suggests a potentially protective role for interleukin 5 (IL-5) in sepsis; however, the loss of eosinophils in this disease presents a paradox. OB...

journal_title：American journal of respiratory and critical care medicine

authors： Linch SN,Danielson ET,Kelly AM,Tamakawa RA,Lee JJ,Gold JA

更新日期：2012-08-01 00:00:00

abstract：RATIONALE:No methodical assessment of the lung, cardiac, and sleep function of patients surviving an acute hypercapnic respiratory failure episode requiring admission to the intensive care unit (ICU) has been reported in the literature. OBJECTIVES:To prospectively investigate the prevalence and impact of comorbidities...

journal_title：American journal of respiratory and critical care medicine

authors： Adler D,Pépin JL,Dupuis-Lozeron E,Espa-Cervena K,Merlet-Violet R,Muller H,Janssens JP,Brochard L

更新日期：2017-07-15 00:00:00

abstract：:The failure of patients to adhere to physician-prescribed regimens, either pharmacologic or behavioral, has been well documented in medical literature. Poor adherence to asthma medication regimens has been repeatedly demonstrated in both children and adults, with rates of nonadherence commonly reported from 30 to 70%....

journal_title：American journal of respiratory and critical care medicine

authors： Rand CS,Wise RA

更新日期：1994-02-01 00:00:00

abstract：:Muscle nerve sympathetic activity (MSA), the interval between two R-waves in the ECG, or the interbeat interval (RR-interval), and blood pressure (BP) were recorded in 10 awake patients with obstructive sleep apnea (OSA) and in nine sex- and age-matched controls. Changes in RR-interval and MSA, evoked by sodium nitrop...

journal_title：American journal of respiratory and critical care medicine

authors： Carlson JT,Hedner JA,Sellgren J,Elam M,Wallin BG

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Current classification of pulmonary hypertension (PH) is based on a relatively simple combination of patient characteristics and hemodynamics. This limits customization of treatment, and lacks the clarity of a more granular identification based on individual patient phenotypes. Rapid advances in mechanistic ...

journal_title：American journal of respiratory and critical care medicine

authors： Dweik RA,Rounds S,Erzurum SC,Archer S,Fagan K,Hassoun PM,Hill NS,Humbert M,Kawut SM,Krowka M,Michelakis E,Morrell NW,Stenmark K,Tuder RM,Newman J,ATS Committee on Pulmonary Hypertension Phenotypes.

更新日期：2014-02-01 00:00:00

abstract：:The number and significance of airway eosinophils in stable COPD is controversial. Aims of this study were to evaluate airway inflammation in patients with stable COPD compared with other groups, and to examine the correlations between inflammatory markers and functional indices of airway obstruction. Cellular analysi...

journal_title：American journal of respiratory and critical care medicine

authors： Balzano G,Stefanelli F,Iorio C,De Felice A,Melillo EM,Martucci M,Melillo G

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:Recent cohort studies in chronic obstructive pulmonary disease (COPD) have questioned the validity of previously reported associations between inhaled corticosteroids (ICS) and reductions in mortality and rehospitalization in observational studies. Using time-dependent versions of statistical survival models,...

journal_title：American journal of respiratory and critical care medicine

authors： Kiri VA,Pride NB,Soriano JB,Vestbo J

更新日期：2005-08-15 00:00:00

abstract：:In 1976-1992 245 new cases of asthma induced by diisocyanates were diagnosed, caused by hexamethylene diisocyanate (HDI) in 39%, diphenylmethane diisocyanate (MDI) in 39%, and toluene diisocyanate (TDI) in 17% of the cases. Our aim was to study the clinical outcome of diisocyanate-induced asthma. A questionnaire was s...

journal_title：American journal of respiratory and critical care medicine

authors： Piirilä PL,Nordman H,Keskinen HM,Luukkonen R,Salo SP,Tuomi TO,Tuppurainen M

更新日期：2000-08-01 00:00:00

abstract：RATIONALE:MicroRNAs (miRNAs) destabilize mRNA transcripts and inhibit protein translation. miR-145 is of particular interest in cystic fibrosis (CF) as it has a direct binding site in the 3'-untranslated region of CFTR (cystic fibrosis transmembrane conductance regulator) and is upregulated by the CF genetic modifier T...

journal_title：American journal of respiratory and critical care medicine

authors： Lutful Kabir F,Ambalavanan N,Liu G,Li P,Solomon GM,Lal CV,Mazur M,Halloran B,Szul T,Gerthoffer WT,Rowe SM,Harris WT

更新日期：2018-03-01 00:00:00

abstract：:We investigated the relationship between annual change in pulmonary function and changes in respiratory symptoms among male grain elevator workers who participated in a health surveillance program mandated by Labour Canada. The surveillance was conducted every 3 yr starting from the period 1978 to 1981. The 1,211 work...

journal_title：American journal of respiratory and critical care medicine

authors： Senthilselvan A,Pahwa P,Wang P,McDuffie HH,Dosman JA

更新日期：1996-02-01 00:00:00

abstract：:Central airway obstruction is a problem facing all medical and surgical subspecialists caring for patients with chest diseases. The incidence of this disorder appears to be rising because of the epidemic of lung cancer; however, benign causes of central airway obstruction are being seen more frequently as well. The mo...

journal_title：American journal of respiratory and critical care medicine

authors： Ernst A,Feller-Kopman D,Becker HD,Mehta AC

更新日期：2004-06-15 00:00:00

abstract：RATIONALE:An asthma predisposition locus on chromosome 17q12-q21 has recently been replicated in different ethnic groups. OBJECTIVES:To characterize the asthma and atopy phenotypes in early childhood that associate with the 17q12-21 locus. METHODS:The single nucleotide polymorphism (SNP), rs7216389, was genotyped in ...

journal_title：American journal of respiratory and critical care medicine

authors： Bisgaard H,Bønnelykke K,Sleiman PM,Brasholt M,Chawes B,Kreiner-Møller E,Stage M,Kim C,Tavendale R,Baty F,Pipper CB,Palmer CN,Hakonarsson H

更新日期：2009-02-01 00:00:00

abstract：:Patients with impaired pulmonary function are at increased risk for the development of postoperative complications. Recently exercise testing and predicted postoperative (ppo) function have gained increasing importance in the evaluation of lung resection candidates. We prospectively evaluated an algorithm for the preo...

journal_title：American journal of respiratory and critical care medicine

authors： Wyser C,Stulz P,Solèr M,Tamm M,Müller-Brand J,Habicht J,Perruchoud AP,Bolliger CT

更新日期：1999-05-01 00:00:00

abstract：:The epithelium of the paranasal sinuses produces nitric oxide (NO), which probably plays a major role in the nonspecific defense of these cavities through its bacteriostatic and cilia motility stimulation properties. Abundant eosinophils of nasal polyps potentially generate superoxide anion (O2-*), but NO and O2-* ina...

journal_title：American journal of respiratory and critical care medicine

authors： Pasto M,Serrano E,Urocoste E,Barbacanne MA,Guissani A,Didier A,Delisle MB,Rami J,Arnal JF

更新日期：2001-01-01 00:00:00

abstract：:Exaggerated airway narrowing in response to bronchoconstricting stimuli is a characteristic feature of asthmatic subjects. It is unknown whether the site of airway narrowing differs in asthmatic subjects from that observed in normal subjects. Increased airway wall thickness has been suggested as a contributing cause f...

journal_title：American journal of respiratory and critical care medicine

authors： Okazawa M,Müller N,McNamara AE,Child S,Verburgt L,Paré PD

更新日期：1996-11-01 00:00:00

abstract：:Cyclophosphamide-induced lung toxicity may be difficult to recognize because of the presence of confounding variables such as concomitant use of other cytotoxic drugs, opportunistic infections, diffuse pulmonary malignancy, radiation pneumonitis, and oxygen toxicity. The purpose of this retrospective analysis was to i...

journal_title：American journal of respiratory and critical care medicine

authors： Malik SW,Myers JL,DeRemee RA,Specks U

更新日期：1996-12-01 00:00:00

abstract：:The predisposing factors and complications of unplanned extubation (UEX) in mechanically ventilated adult patients are not well recognized. We designed a prospective multicenter observational study to identify risk factors and describe the complications of UEX. We followed 426 ventilated patients over a 2-mo period. C...

journal_title：American journal of respiratory and critical care medicine

authors： Boulain T

更新日期：1998-04-01 00:00:00

abstract：:It has been nearly a century since the first suggestion that a soluble factor in plasma or serum might be responsible for the symptoms of allergic disease and asthma, and more than 30 yr since immunoglobulin E (IgE) was identified as the key molecule in mediating what are now described as type 1 hypersensitivity react...

journal_title：American journal of respiratory and critical care medicine

authors： Platts-Mills TA

更新日期：2001-10-15 00:00:00

abstract：RATIONALE:Although it is widely assumed that the incidence of childhood respiratory allergies to common aeroallergens is directly related to allergen exposure in early life, few longitudinal studies have investigated this issue, and available data are scarce and mainly limited to high-risk groups. OBJECTIVES:To assess...

journal_title：American journal of respiratory and critical care medicine

authors： Torrent M,Sunyer J,Garcia R,Harris J,Iturriaga MV,Puig C,Vall O,Anto JM,Newman Taylor AJ,Cullinan P

更新日期：2007-09-01 00:00:00

abstract：RATIONALE:Asthma commonly originates in early life in association with impaired lung function, which tracks to adulthood. OBJECTIVES:Within the context of a prospective birth cohort study, we investigated the association between single nucleotide polymorphisms (SNPs) in a disintegrin and metalloprotease 33 (ADAM33) ge...

journal_title：American journal of respiratory and critical care medicine

authors： Simpson A,Maniatis N,Jury F,Cakebread JA,Lowe LA,Holgate ST,Woodcock A,Ollier WE,Collins A,Custovic A,Holloway JW,John SL

更新日期：2005-07-01 00:00:00

abstract：RATIONALE:Chronic hypoxia induces pulmonary vascular remodeling, pulmonary hypertension, and right ventricular hypertrophy. At present, little is known about mechanisms driving these responses. Hypoxia-inducible factor-1α (HIF-1α) is a master regulator of transcription in hypoxic cells, up-regulating genes involved in ...

journal_title：American journal of respiratory and critical care medicine

authors： Ball MK,Waypa GB,Mungai PT,Nielsen JM,Czech L,Dudley VJ,Beussink L,Dettman RW,Berkelhamer SK,Steinhorn RH,Shah SJ,Schumacker PT

更新日期：2014-02-01 00:00:00

abstract：:We used various ovalbumin sensitization and challenge protocols to determine the importance of the route of allergen administration and the genetic background in modulating the physiologic, inflammatory, and immunologic features characteristic of allergen-induced asthma. In BALB/c mice, induction of maximal airway hyp...

journal_title：American journal of respiratory and critical care medicine

authors： Zhang Y,Lamm WJ,Albert RK,Chi EY,Henderson WR Jr,Lewis DB

更新日期：1997-02-01 00:00:00

abstract：:In 11 ventilator-dependent patients, we undertook a head-to-head comparison of patient-ventilator interaction during four ventilator modes: assist-control ventilation (ACV), intermittent mandatory ventilation (IMV), pressure support (PS), and a combination of IMV and PS. Progressive increases in IMV rate and PS level ...

journal_title：American journal of respiratory and critical care medicine

authors： Leung P,Jubran A,Tobin MJ

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:The clinical utility of bronchoalveolar lavage fluid (BAL) cell analysis for the diagnosis and management of patients with interstitial lung disease (ILD) has been a subject of debate and controversy. The American Thoracic Society (ATS) sponsored a committee of international experts to examine all relevant l...

journal_title：American journal of respiratory and critical care medicine

authors： Meyer KC,Raghu G,Baughman RP,Brown KK,Costabel U,du Bois RM,Drent M,Haslam PL,Kim DS,Nagai S,Rottoli P,Saltini C,Selman M,Strange C,Wood B,American Thoracic Society Committee on BAL in Interstitial Lung Disease.

更新日期：2012-05-01 00:00:00

abstract：:The renin angiotensin system plays an important role in the development of pulmonary artery remodeling and right ventricular hypertrophy in hypoxia-induced pulmonary hypertension as may occur in patients with COPD. Several polymorphisms of genes encoding for components of the renin angiotensin system such as the M235T...

journal_title：American journal of respiratory and critical care medicine

authors： van Suylen RJ,Wouters EF,Pennings HJ,Cheriex EC,van Pol PE,Ambergen AW,Vermelis AM,Daemen MJ

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Extracellular nucleotides have recently been identified as proinflammatory mediators involved in asthma pathogenesis by signaling via purinergic receptors, but the role of the purinergic receptor type 6 (P2Y6R) has not been previously investigated. OBJECTIVES:To investigate the role of P2Y6R in asthma pathog...

journal_title：American journal of respiratory and critical care medicine

authors： Vieira RP,Müller T,Grimm M,von Gernler V,Vetter B,Dürk T,Cicko S,Ayata CK,Sorichter S,Robaye B,Zeiser R,Ferrari D,Kirschbaum A,Zissel G,Virchow JC,Boeynaems JM,Idzko M

更新日期：2011-07-15 00:00:00

abstract：:The role of lipoxygenase metabolites in the pathogenesis of endotoxin (LPS)-induced lung injury remains to be clarified. We investigated the contribution of peptide leukotrienes to LPS-induced acute lung injury using a potent antagonist, ONO-1078 (ONO). Experimental groups consisted of a saline group (n = 10), an LPS ...

journal_title：American journal of respiratory and critical care medicine

authors： Ishizaka A,Hasegawa N,Sakamaki F,Tasaka S,Nakamura H,Kishikawa K,Yamada A,Obata T,Sayama K,Urano T

更新日期：1994-11-01 00:00:00

abstract：:The length of time that blood remains in the pulmonary capillary is an important variable in gas exchange. We have investigated the distribution of capillary transit times in isolated rabbit lungs perfused with a bicarbonate-free buffer. The time course of gas exchange was monitored by enclosing the lungs in a plethys...

journal_title：American journal of respiratory and critical care medicine

authors： Klocke RA,Schünemann HJ,Grant BJ

更新日期：1995-12-01 00:00:00