Sinus histiocytosis (Rosai-Dorfman disease) clinically limited to the skin. An immunohistochemical and ultrastructural study.

Abstract:

:A case study of sinus histiocytosis of Rosai-Dorfman (SH) clinically limited to the skin is presented with immunohistochemical study of the infiltrate, in both paraffin and cryostat sections. Factor XIIIa, a dendrocyte marker, was demonstrated in the cytoplasm of histiocytes. This feature had not been previously reported in this disease. In addition, the cells expressed S100 protein, CD4, CD1a, CD68, and CD11c. This immunophenotyping study suggests that SH could affect the antigen-presenting activity of Factor XIIIa cells, i.e., the skin dermal dendrocyte.

journal_name

J Cutan Pathol

authors

Perrin C,Michiels JF,Lacour JP,Chagnon A,Fuzibet JG

doi

10.1111/j.1600-0560.1993.tb01278.x

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

368-74

issue

4

eissn

0303-6987

issn

1600-0560

journal_volume

20

pub_type

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