[Bromocriptine and tamoxifen--a new therapeutic approach in suppression-resistant prolactin-secreting adenomas].

Abstract:

:In the present study the combination of tamoxifen and bromocriptine was tried for the suppression of prolactin in prolactin secreting adenomas which were resistant to suppression with bromoergocriptine alone. 10 women under treatment with 2.5-10 mg of parlodel (bromocriptine) for pituitary tumours of various sizes were additionally treated with tamoxifen 10-20 mg. (nolvadex) daily. Two patients had a previous incomplete resection for chromophobe adenomas. The other patients refused operation. Two women were also studied who did not tolerate a bromoergocriptine therapy because of side effects. In 6 of the 10 women with combination treatment a satisfactory suppression of the prolactin was observed. Four women were cleared of their amenorrhoea and galactorrhoea. One woman conceived. One woman lost her frigidity. Three women, among those the two with severe side effects from bromoergocriptine, tolerated the combined treatment well. Four women showed no success with the combined treatment. The effectiveness of the combined treatment was not correlated with the size of the tumour nor the clinical or biochemical baseline. The results lead to the conclusion that tamoxifen is capable of improving the suppression of prolactin or render the adenomas suppressible in a large number of cases.

authors

Völker W,Gehring WG,von zur Mühlen A,Schneider J

doi

10.1055/s-2008-1037161

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

790-7

issue

11

eissn

0016-5751

issn

1438-8804

journal_volume

42

pub_type

杂志文章
  • [The risk of yeast infection, of the newborn during and after delivery (author's transl)].

    abstract::The importance of yeast infections in obstetrics was investigated in 200 pregnant women and their newborns. In the maternity patients the vagina was tested shortly before the delivery and the mouth of the neonates was tested 1 day prior to the discharge from the hospital. In 22% of the pregnant women and in 8,4% of th...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: van Maillot K,Leipold W

    更新日期:1975-05-01 00:00:00

  • [Antibiotic prevention in gynecology. Concentrations of ceftizoxime in the serum, myometrium, endometrium and fallopian tubes].

    abstract::34 patients received an intravenous bolus injection of 2 g ceftizoxime over 5 min at various times before abdominal or vaginal hysterectomy. Ceftizoxime concentrations in myometrium were substantially higher than in salpinges and endometrium. Tissue concentrations of 4 micrograms/g could be maintained for at least 3 h...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036734

    authors: Daschner F,Just HM,Brändle J,Zahn V

    更新日期:1983-11-01 00:00:00

  • [Prenatal diagnosis of holoprosencephaly with postaxial polydactyly, cardiopathy with normal karyotype].

    abstract::Holoprosencephaly is a malformation complex, in which the foetal forebrain (prosencephalon) fails to cleave. The aetiology of holoprosencephaly is heterogeneous. In the last years, a new malformation syndrome has been described, including holoprosencephaly, postaxial polydactyly, congenital heart defects and normal ka...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1023813

    authors: Salamanca A,Padilla MC,Sabatel RM,Motos MA,Stemper K,Gonzalez-Gomez F

    更新日期:1992-12-01 00:00:00

  • [Cytologic studies after insertion of intrauterine contraceptive devices (IUD) (author's transl)].

    abstract::Cervical smears of 554 women using IUDs were examined. The following criteria were evaluated: 1. Age distribution, 2. maturation index of the vaginal epithelium, 3. vaginal flora, 4. cytologic criteria of inflammation, 5. period of time between insertion of the IUD and the cytological examination, 6. final cytologic d...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037354

    authors: Prinz W,Noack J,Kraus H,Schuhmann RA

    更新日期:1981-03-01 00:00:00

  • [Cervix cytology and primary malignancies of the gastrointestinal tract].

    abstract::During the cancer check-up of a 46-year-old woman a PAP V was diagnosed in the cervical scrapings. The atypical cells of the abrasion specimens from the corpus uteri arouse strong suspicion of malignancy. Connected with the clinical data, this finding primarily indicated a metastatic involvement of the inner genitals....

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036064

    authors: Jaluvka V,Engelhardt W

    更新日期:1987-12-01 00:00:00

  • Significance of Ovarian Function Suppression in Endocrine Therapy for Breast Cancer in Pre-Menopausal Women.

    abstract::Ovarian function suppression (OFS) for treating breast cancer in pre-menopausal women was introduced for the first time in the late 19th century as bilateral oophorectomy. It was not until the 1960s that the oestrogen receptor was identified and a test for detecting endocrine sensitivity of the breast cancer was devel...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章,评审

    doi:10.1055/s-0042-106389

    authors: Scharl A,Salterberg A

    更新日期:2016-05-01 00:00:00

  • [Perioperative infection prevention with cefotaxime].

    abstract::In a study comprising 172 patients who had been abdominally or vaginally hysterectomised, the effectivity of short-term prophylaxis with cefotaxim on various infection parameters was examined. The 100 patients of the prophylaxis group showed a significant reduction (p less than 0.01) of postoperative fever and of pelv...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036203

    authors: Hägele D,Berg D

    更新日期:1985-01-01 00:00:00

  • [The balloon vaginoscopy (author's transl)].

    abstract::The regular Huffman vaginoscope is fitted with an endotracheal sleeve to obtain a balloon vaginoscope. The balloon vaginoscope makes inspection of the cervix in children much easier, and facilitates the removal of foreign bodies from the vagina of children. Vaginoscopy can be learned easier with the balloon vaginoscop...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Terruhn V

    更新日期:1979-01-01 00:00:00

  • Vaginal Estrogen Therapy for Patients with Breast Cancer.

    abstract::On account of the good prognosis for patients with breast cancer, improving or maintaining the quality of life in the aftercare period is becoming more and more important. In particular, the increasing usage of aromatase inhibitors in the past few years has led to an increased incidence of vaginal atrophy with symptom...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0033-1350876

    authors: Moegele M,Buchholz S,Seitz S,Lattrich C,Ortmann O

    更新日期:2013-10-01 00:00:00

  • [Central European study of the development of secondary sex characteristics in girls. I. Axillary hair as the 4th secondary sex characteristic].

    abstract::As a part of the Central European Study a long-term study of the pubertal development of 687 Hungarian girls was undertaken and the findings compared with those of a cross-sectional study of a group of girls from Münster. In addition to assessment of the breast and pubic hair according to Tanner's classification, the ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026624

    authors: Schlummer AP,Beller FK,Borsos A,Csoknyay I,Kieback D

    更新日期:1988-11-01 00:00:00

  • [Plasma concentration of PGE2, PGA2 and PGF2 alpha in the course of pregnancy (author's transl)].

    abstract::Plasma levels of PGE2, PGA2 and PGF2 alpha were determined by radioimmunoassay in maternal cubital vein blood of 210 women and once during pregnancy. In the course of pregnancy plasma levels of these prostaglandins varied considerably: 0,09-1,83 ng PGE2/ml, 0,12-2,8 ng PGA2/ml and 0,04-0,5 ng PGF2 alpha/ml. At term (4...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Cornely M,Klappstein I,Beutnagel H,Schönhöfer PS

    更新日期:1979-09-01 00:00:00

  • [Unusual findings in gynecological surgery I. Case report of a retroperitoneal myoma (author's transl)].

    abstract::A 65 year old woman, who had vaginal hysterectomy 24 years ago, was admitted to the hospital because of a lower abdominal tumor. When laparotomy was performed a retroperitoneal myoma with a weight of 1,8 kg and 22 cm in diameter was found. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037345

    authors: Schwanitz V,Distler W

    更新日期:1980-04-01 00:00:00

  • [Significance of vascular changes in the colposcopic diagnosis of precancerous and early stages of cervical cancer].

    abstract::Blood vessels are visible in an average of 80% of patients on whom colposcopy is performed. This percentage share increases if there are pathological changes. The following vascular types occur as characteristic criteria in cervical intraepithelial neoplasia (CIN) and in carcinoma, their classification being based on ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036721

    authors: Madej J

    更新日期:1983-10-01 00:00:00

  • [Malaria relapse in the puerperium].

    abstract::During the last six years we observed four malaria relapses shortly after delivery. In three cases the relapse occurred subsequent to Caesarean section, and in one case shortly after normal uncomplicated delivery. Case histories revealed that these women had previously stayed in the tropical or subtropical zones. The ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036513

    authors: Harms E,Degner-Harms I,Klöck FK

    更新日期:1984-11-01 00:00:00

  • Tuberculosis in Pregnancy - a Summary.

    abstract::In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be a...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0774-7924

    authors: Wolf B,Krasselt M,de Fallois J,von Braun A,Stepan H

    更新日期:2019-04-01 00:00:00

  • [Surgery of prolapse and incontinence in Austria--current status and prospects].

    abstract::In early 1989, we sent a questionnaire to all 89 Departments of Gynaecology in Austria. Questions covered the number and type of gynaecological operations performed, perioperative management, and diagnosis and treatment of descent and urinary incontinence. 90% of questionnaires were returned. We found that currently 2...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026481

    authors: Riss P,Ralph G,Anderl P

    更新日期:1990-04-01 00:00:00

  • Subcutaneous Administration of Monoclonal Antibodies in Oncology.

    abstract::Treatment with monoclonal antibodies (mabs) has become an established component of oncological therapy. The monoclonal antibodies available for this purpose are mainly administered intravenously in individually adapted doses according to body weight over longer treatment times. For other chronic diseases such as, for ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-0034-1368173

    authors: Jackisch C,Müller V,Maintz C,Hell S,Ataseven B

    更新日期:2014-04-01 00:00:00

  • [Problems and limits of mammographic cancer diagnosis. Comparison of preoperative radiologic diagnosis with histologic findings in 335 patients with subcutaneous mastectomy].

    abstract::Subcutaneous mastectomy was performed in 335 patients between 1974 and 1982. In 265 of these, original mammographies were available which were analysed retrospectively and compared with the final histological finding of the subcutaneous mastectomy preparation. The rate of newly discovered non-invasive carcinomas in th...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036377

    authors: Arabin B,von Fournier D,Kubli F,Müller A,Weber E

    更新日期:1985-09-01 00:00:00

  • Is There a Relationship Between Vitamin D Deficiency Status and PCOS in Infertile Women?

    abstract::Introduction It is still unclear in the literature whether low vitamin D levels play a role in the pathogenesis of polycystic ovary syndrome (PCOS), especially with respect to the regulation of anti-Müllerian hormone (AMH). Therefore, we aimed to investigate whether there could be a relationship between vitamin D defi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/a-0871-6831

    authors: Arslan E,Gorkem U,Togrul C

    更新日期:2019-07-01 00:00:00

  • [Estrogen and progesterone receptors in corpus uteri carcinoma and their clinical significance].

    abstract::In 49 carcinomas of the endometrium of varying clinical stages the estrogen and progesterone receptors were studied by charcoal absorption methods. The cases were studied between 1979 and 1981. 64% of the investigated cases were receptor positive, 35% were receptor negative. Estrogen receptors were detected in 61% and...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037179

    authors: Kleine W,Fuchs A,deGregorio G,Geyer H

    更新日期:1982-12-01 00:00:00

  • [FSH-producing hypophyseal tumor in a 13-year-old girl].

    abstract::We report on a 13 year old girl with a FSH, secreting pituitary tumour, who was presented with recurrent bleeding disorders. Gynaecological examination revealed large cystic ovarian tumours on both sides. The endocrinological work-up showed high serum levels of oestradiol and FSH, and low serum levels of testosterone ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026437

    authors: Etzrodt A,Etzrodt H,Hey O

    更新日期:1990-01-01 00:00:00

  • [Duffy-blood-factor incompatibility during pregnancy (author's transl)].

    abstract::Routine screening of maternal antibodies showed presence of anti-Fya (from the antigen Fya of Duffy Blood Group System) in a 25 years old second time pregnant woman. The spectroscopic examination of amniotic fluid has been carried out and gave values which decrease within Zone II. In the beginning of 39. week of gesta...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Sachs H,Müller K

    更新日期:1977-07-01 00:00:00

  • [Sarcoma botryoides of the cervix uteri as cause for haemorrhages in childbed (author's transl)].

    abstract::A case of a 21-year-old woman with a botryoid sarcoma of the cervix uteri, who consulted a specialist for women's diseases because of non stopping haemorrhages in childbed, is reported. Neither radical operation nor radiation nor treatment with cytostatica could arrest the extreme impetuous growth of this tumor. ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Gödtel R,Schäfer A

    更新日期:1978-06-01 00:00:00

  • [Slit drainage versus Redon drainage in a clinical comparison--initial experiences with a new kind of wound drainage system].

    abstract::In a prospective, randomised study we compared the clinical properties of the established Redon drain with a new type of drain called "slit drain". Both types of drains were examined regarding the amount of drained fluid, the time elapsing until removal of the drain, the frequency of occlusion of the lumen as well as ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1055/s-2007-1026165

    authors: Brandner P,Neis KJ,Hettenbach A,Schmidt W

    更新日期:1991-05-01 00:00:00

  • [Plastic surgery correction of combination craniofacial malformations. A survey for the obstetrician].

    abstract::Complex malformations of the skeleton of the cranium and face are mostly first discovered by the obstetrician. Almost all anomalies can be corrected already at infant age by means of update craniofacial surgery, provided they are diagnosed well in time and treatment is initiated directly. Surgery should be performed b...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1036113

    authors: Mühlbauer W,Heeckt P,Anderl H,Schmidt A,Höpner F,Vertesy E,Schaarschmidt B

    更新日期:1989-11-01 00:00:00

  • [Pelviscopic surgery in gynaecology (author's transl)].

    abstract::Surgery of the fallopian tubes has today developed into pelviscopic surgery. The development of suitable instruments such as the tube set, a new endocoagulation method were prerequisites for this development. Operative therapeutic pelviscopic surgery is a development past laparotomy. It is now possible to treat adhesi...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:

    authors: Semm K

    更新日期:1977-11-01 00:00:00

  • [Intramyometrial PGF2 alpha administration in the control of severe atonic postpartum hemorrhage].

    abstract::The authors report on five cases of massive atonic uterine haemorrhage which could be influenced neither by repeated application of oxytocin nor by methylergometrin. Intramyometrial application of PGF2 alpha succeeded in inducing a satisfactory uterine tone and stopping the haemorrhage. With regard to own experiences ...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1026501

    authors: Meinen K,Lange R,Breinl H

    更新日期:1988-04-01 00:00:00

  • [Early diagnosis of fetal malformation by ultrasonography (author's transl)].

    abstract::Today, echography can be considered as routine diagnosis in every pregnancy. Besides the detection of growth retardation very often in early stages of the fetal life malformations can be diagnosed incompatible with postnatal life. Reviewing the cases of the II. Women's Department of Obstetrics and Gynaecology in Vienn...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2008-1037231

    authors: Bernaschek G,Dadak C,Kratochwil A

    更新日期:1980-10-01 00:00:00

  • [The prognostic significance of cathepsin D in primary breast cancer].

    abstract::The prognostic significance of the lysosomal protease cathepsin D in breast cancer was evaluated in a retrospective study. Cathepsin D was measured in 346 deep-frozen (-70 degrees C) cytosol specimens of primary breast carcinomas (1982-1990). Among the established prognostic factors, only axillary lymph node involveme...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1022337

    authors: Crombach G,Ingenhorst A,Göhring UJ,Scharl A,Schaeffer HJ,Stützer H,Bolte A

    更新日期:1994-10-01 00:00:00

  • [Treatment of tubal pregnancy by pelviscopy--complications, pregnancy and recurrence rates].

    abstract::From 1977-1989, 298 ectopic pregnancies were treated pelviscopically at the Dept. of Gynaecology Hospital of the University of Kiel. 26 tubes were already ruptured. In 251 patients (84%), organ preserving treatment was possible, 205 treatment by longitudinal salpingotomy. 46 tubal abortions were extracted. In 47 patie...

    journal_title:Geburtshilfe und Frauenheilkunde

    pub_type: 杂志文章

    doi:10.1055/s-2007-1026197

    authors: Mecke H,Argiriou C Semm K

    更新日期:1991-07-01 00:00:00