Abstract:
:Introduction It is still unclear in the literature whether low vitamin D levels play a role in the pathogenesis of polycystic ovary syndrome (PCOS), especially with respect to the regulation of anti-Müllerian hormone (AMH). Therefore, we aimed to investigate whether there could be a relationship between vitamin D deficiency status and PCOS. Materials and Methods A total of 146 infertile women were divided into two groups according to their ovarian reserve patterns: (i) normal (NOR), and (ii) high (PCOS). The participants were also categorized into two groups according to vitamin D concentrations: (i) Group A < 10 ng/mL, and (ii) Group B 10 - 20 ng/mL. Samples were obtained and analyzed for estradiol (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone (TT), 17-hydroxyprogesterone (17-OHP), dehydroepiandrosterone sulfate (DHEA-S) and AMH. Results In the NOR group, there were significant differences between Group A and Group B in terms of anthropometric characteristics (p < 0.05, for all). The women in both Group A and Group B had similar AMH concentrations (p > 0.005). Only the NOR group showed a significant though moderate negative correlation between 25(OH)D levels and anthropometric parameters. AMH levels were not correlated with 25(OH)D levels in the NOR or the PCOS group (r = - 0.112, p = 0.008; r = 0.027, p = 0.836). Multivariate regression analysis showed no impact of 25(OH)D on other study parameters. Only AMH measurements were significant enough (p < 0.001) to differentiate between PCOS and NOR patterns. Conclusion We found no difference in serum 25(OH)D and AMH levels between women with and women without PCOS. No correlation could be demonstrated between 25(OH)D and AMH in the PCOS group or controls. :Einleitung In der Literatur ist immer noch unklar, ob ein niedriger Vitamin-D-Spiegel eine Rolle bei der Pathogenese von polyzystischem Ovarialsyndrom (PCOS) spielt, besonders in Bezug auf die Regulierung des Anti-Müller-Hormons (AMH). Ziel dieser Studie war es daher zu untersuchen, ob es eine Beziehung zwischen Vitamin-D-Mangel und PCOS gibt. Material und Methoden Es wurden insgesamt 146 unfruchtbare Frauen in die Studie aufgenommen und entsprechend ihrer ovariellen Reserve in 2 Gruppen eingeteilt: (i) normale ovarielle Reserve (NOR), und (ii) hohe ovarielle Reserve (PCOS). Die Teilnehmerinnen wurden zusätzlich je nach Vitamin-D-Spiegel in 1 von 2 Gruppen unterteilt: (i) Gruppe A < 10 ng/mL, und (ii) Gruppe B 10 – 20 ng/mL. Den Teilnehmerinnen wurden Blutproben zur Bestimmung von Östradiol (E2), follikelstimulierendem Hormon (FSH), luteinisierendem Hormon (LH), Gesamttestosteron (TT), 17-Hydroxyprogesteron (17-OHP), Dehydroepiandrosteron-Sulfat (DHEA-S) und AMH entnommen. Ergebnisse In der NOR-Gruppe gab es signifikante Unterschiede zwischen Gruppe A und Gruppe B hinsichtlich der anthropometrischen Daten (p < 0,05, für alle Gruppen). Die AMH-Konzentrationen waren ähnlich für Frauen aus Gruppe A und Frauen aus Gruppe B (p > 0,005). Nur bei der NOR-Gruppe fand sich eine signifikante moderate negative Korrelation zwischen 25(OH)D-Spiegel und anthropometrischen Parametern. AMH-Werte korrelierten weder in the NOR-Gruppe noch in der PCOS-Gruppe mit 25(OH)D-Werten (r = − 0,112, p = 0,008; r = 0,027, p = 0,836). Bei der multivariaten Regressionsanalyse zeigten sich keine Auswirkungen von 25(OH)D-Werten auf andere Studienparameter. Nur die AMH-Werte waren signifikant genug (p < 0,001), um zwischen PCOS und NOR zu unterscheiden. Schlussfolgerung Wir fanden keinen Unterschied in den 25(OH)D-Werten und den AMH-Werten zwischen Frauen mit und Frauen ohne PCOS. Es gab keine Hinweise auf eine Korrelation zwischen 25(OH)D-Werten und AMH-Werten in der PCOS-Gruppe und der Kontrollgruppe.
journal_name
Geburtshilfe Frauenheilkdjournal_title
Geburtshilfe und Frauenheilkundeauthors
Arslan E,Gorkem U,Togrul Cdoi
10.1055/a-0871-6831subject
Has Abstractpub_date
2019-07-01 00:00:00pages
723-730issue
7eissn
0016-5751issn
1438-8804pii
8716831journal_volume
79pub_type
杂志文章abstract::The prenatal diagnosis of omphalocele is reported. The characteristic signs in the ultra-sound scan were a small trunk, an angulation of the spine and mass adjacent to the absomen of the fetus. By x-ray amniography the ultra-sound findings were confirmed at further abnormalities outlined. The alpha fetal protein level...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-12-01 00:00:00
abstract::As a key area of gynaecology, urogynaecology has undergone impressive changes in the past few years. Together with the high prevalence of functional pelvic floor disorders, modern anaesthesia procedures and the introduction of new, innovative minimally invasive operation techniques have led to a dramatic increase in t...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1298335
更新日期:2012-03-01 00:00:00
abstract::A case of spontaneous perforation of a tension ulceration in procidentia in an 82 year old woman is reported. A similar case has not been reported in the literature. The extra-ordinary rarity of this observation justifies the publication of this case. The main etiologic factor is considered to be a local perfusion pro...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037197
更新日期:1981-06-01 00:00:00
abstract::According to a judgement by the German Federal Court of 17 December 1991 the surgeon is legally bound to inform the patient before hand of the risk of a possible homologous blood transfusion during surgery. If the transfusion probability exceeds 5%, this obligation is really relevant, 228 patients with primary breast ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023526
更新日期:1995-10-01 00:00:00
abstract::Introduction: Use of hormone therapy (HT) has declined dramatically in recent years. Some studies have reported that HT use before a diagnosis of breast cancer (BC) may be a prognostic factor in postmenopausal patients. This study aimed to examine the prognostic relevance of HT use before BC diagnosis. Methods: Four B...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0035-1546149
更新日期:2015-06-01 00:00:00
abstract::Results of HCG-determinations in human serum and cystfluid of benign mammary tumors are presented. HCG was determined gy RIA in 40 samples from 30 patients with different forms of fibro-cystic mastitis. In 60% of the cases positive results were obtained. It is still unclear, whether the demonstrated substance is nativ...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-08-01 00:00:00
abstract::Following the originally dominant matriarchate, patriarchy took over and still reigns in present-day society, although we are now in the midst of a period of transition towards a man/woman relationship on partnership basis. This principle of "two units combining to form one", this unification of two opposing and compl...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035960
更新日期:1986-10-01 00:00:00
abstract::The internal genitalia in extraordinary forms of müllerian duct malformations were studied in ten patients wit the so called Mayer-Rokitansky-Küster syndrome. Additional abnormalities of the kidneys and the urinary tract were observed in seven cases. Unilateral malformations of the genitalia were not necessarily combi...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-05-01 00:00:00
abstract::A report on the result of a representative survey of family planning behavior in the Federal Republic of Germany in 1985. Interviewers from the EMNID Institute questioned 1267 German women aged between 15 and 45. Of the women interviewed, 6.1% had been sterilized, while in 1.3% of cases, their partner had been sterili...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1036340
更新日期:1986-12-01 00:00:00
abstract::The therapy of choice for breast cancer patients requiring adjuvant chemo- or radiotherapy is increasingly guided by the principle of weighing the individual effectiveness of the therapy against the associated side effects. This has only been made possible by the discovery and validation of modern biomarkers. In the l...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0032-1315340
更新日期:2012-09-01 00:00:00
abstract::Background During cancer therapy, many patients suffer from malnutrition or vitamin deficiency. Treatment for nutrition-related deficiencies should therefore include nutritional therapy and possibly oral or intravenous substitution of micronutrients. Little information exists on multinutrient infusion therapies. The a...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0754-2923
更新日期:2018-11-01 00:00:00
abstract::In a retrospective study the data of 79 patients undergoing radiation-therapy for recurrent endometrial cancer during the years 1972-1978 were evaluated. Group I consisted of 43 patients, who primarily underwent irradiation, group II consisted of 36 patients, who primarily underwent surgery (total abdominal hysterecto...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037069
更新日期:1983-02-01 00:00:00
abstract::A foetus causing attention by disharmonic growth retardation and suspected CTG, died within the 34th week of gestation. The infantile cerebral form (type II) of Gaucher's disease was detected by histological examination. In another pregnancy a second afflicted child was discovered by decreased cerebroside-beta-glucosi...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026239
更新日期:1991-11-01 00:00:00
abstract::Breast cancer is one of the most common malignancies which appear during pregnancy. Since women are increasingly not giving birth until they are at a more advanced age, it can be assumed that the incidence of pregnancy-related breast cancers will continue to increase in the future. Because of pregnancy-induced changes...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0880-9295
更新日期:2019-06-01 00:00:00
abstract::We reported on the results of 703 breast reduction operations performed by a modified technique after McKissock/Strömbeck. Altogether we operated in the last 10 years 360 patients (15-65 years; mean 32 years) at the Johanniter Hospital in Geesthacht. Only such patients were operated on for whom a medical necessity for...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023242
更新日期:1996-01-01 00:00:00
abstract::The study of menstrual pattern and further pregnancy after clomiphene-induced pregnancy showed a comparatively high rate of improved menstrual pattern and of spontaneous conception. 12 of 29 women, who concluded a clomiphene-induced pregnancy more than 2 years ago, showed an improvement of menstrual pattern. Spontaneo...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-10-01 00:00:00
abstract::A report is presented of 141 irradiated cases of recurrent cervical carcinoma, 48 (34%) of the patients have survived for more than 2 years and 21 (15%) have survived yet more than 5 years. It is noticed, that the survival-rate is neither dependent on the localisation of recurrence, nor the beginning date nor the meth...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1039522
更新日期:1980-11-01 00:00:00
abstract::Relevant correlations between the level of the IQ and the reactions to gynaecological interventions and changes in the female reproductive system were detected. These are important in medical practice. The findings are based on psychometric studies in 400 to 500 women. First: Puberty and menarche are experienced in co...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract::Ultrasound examinations in pregnancy were carried out worldwide for over 30 years with no proof of adverse effects on either, mother or child. However, to evaluate the clinical significance of the numerous studies dealing with questions of safety of obstetrical sonography, a basic knowledge of its physical and technic...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1023801
更新日期:1992-12-01 00:00:00
abstract:UNLABELLED:The paper is a review on the actual possibilities and indications of the transplacentar therapy of the fetus. At first some principles of the pharmacodynamics of the materno-placento-fetal unit are explained in order to enable an effective drug administration and reach therapeutic levels in the fetus. Common...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章,评审
doi:10.1055/s-2007-1022783
更新日期:1995-02-01 00:00:00
abstract::In a total of 4149 prenatal patients there were 849 patients who became pregnant following the cessation of the use of oral contraceptives. Results were compared with pregnancies of a similar series of 1000 patients who never had employed contraceptive steroids. Comparison shows a lower incidence of abortion of 5,6% i...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::Smooth muscle neoplasms with atypical proliferative behaviour, but without clear histopathological malignancy represent a diagnostic and therapeutic challenge, as distinction from a sarcoma can be difficult and no guaranteed treatment recommendations are available due to the rarity of these changes. In the event of un...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0034-1368182
更新日期:2014-03-01 00:00:00
abstract::In 17 of 74 patients, in the 20-40 years of age group, who had undergone an organ transplantation (kidney or liver), the course and outcome of pregnancy were evaluated. In three cases, the pregnancies ended in premature miscarriage and in five cases they were terminated for medical reasons. Nine infants were born aliv...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026367
更新日期:1990-10-01 00:00:00
abstract::The capability of Doppler flow velocimetry to predict intrauterine growth retardation is well known. The increased morbidity and mortality rate of postterm newborns is also well known. The aim of our study was to examine if Doppler flow velocimetry is able to indicate foetal jeopardy in the postterm period. Flow veloc...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-1023595
更新日期:1993-09-01 00:00:00
abstract::Cyclosporin A (CyA) was measured simultaneous in breast milk and maternal and fetal blood with a new monoclonal specific radioimmunoassay in a patient who was treated with Cyclosporin A during pregnancy because of kidney transplantation. CyA-levels in breast milk were 15 to 90% higher than in maternal blood. In case o...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1026581
更新日期:1989-02-01 00:00:00
abstract::In 30 sterility patients with normal course of the cycle, 17 OHP already rises significantly one day before the LH-peak. It influences not only progesterone and E2 but also hypothalamic opiate activity and LHRH and LH secretion. 17 OHP is on the one hand discussed as a further trigger for the LH peak and is on the oth...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035886
更新日期:1987-09-01 00:00:00
abstract::Introduction We studied the extent to which an ultrasound-guided vacuum-assisted biopsy device ("hand-held Mammotome") could be used not only as a valuable tool for investigation of suspicious breast lesions, but also therapeutically for the complete removal of breast fibroadenomas. Materials and Methods 132 aspiratio...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0043-100387
更新日期:2017-02-01 00:00:00
abstract::This analysis covers 170 patients with teratomas from 1965-1978 in the Department of Obstetrics and Gynaecology of Heidelberg University. Malignant teratomas were found in two patients; in a special case, a "gliomatosis peritonei" was identified. The histological composition, the degree of maturity, grading and clinic...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1037256
更新日期:1982-03-01 00:00:00
abstract::Introduction: Detection of sentinel lymph nodes (SLN) is the standard procedure to evaluate axillary lymph node status in breast cancer. In addition to known and established procedures such as the blue dye method and scintigraphy, this study investigated the efficacy of a method based on use of the fluorescent dye ind...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0035-1557905
更新日期:2015-09-01 00:00:00
abstract::In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be a...
journal_title:Geburtshilfe und Frauenheilkunde
pub_type: 杂志文章
doi:10.1055/a-0774-7924
更新日期:2019-04-01 00:00:00