Effect of mannitol on experimental focal ischemia in awake monkeys.

Abstract:

:The effect of mannitol on focal cerebral ischemia in cynomolgus monkeys was studied. After the implantation of a snare ligature about the right middle cerebral artery (MCA) and of deep electrodes for measurement of cerebral blood flow, unanesthetized animals underwent 4-hour MCA occlusion. Ten monkeys were untreated, and 12 animals received mannitol (1.2 g/kg i.v.) 20 minutes after occlusion. The preocclusion and postocclusion deep hemispheric cerebral blood flows (mean CBFs) were similar in the treated and untreated groups. Occlusion produced an average decrease in flow of about 50% in both groups. In the mannitol-treated group the mean CBF of 30.0 fell to 15.8 ml/100 g/minute, and in the untreated group the mean CBF of 29.5 fell to 12.5 ml/100 g/minute. Several animals showed increased CBF after mannitol treatment, and there was an average 21% increase in CBF in the mannitol group after treatment, but this was not a statistically significant difference from the untreated group. With regard to clinical status, there was no significant difference between the mannitol group and the untreated group after MCA occlusion. In individual animals, mannitol treatment caused no significant improvement. Two weeks after occlusion, brains were evaluated for infarct size; there was no significant difference between the mannitol and the untreated groups. In this study, treatment with mannitol (1.2 g/kg) 20 minutes after MCA occlusion failed to modify significantly the mean hemispheric CBF, clinical status, or the pathological effects of 4-hour focal cerebral ischemia.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Peña H,Gaines C,Suess D,Crowell RM,Waggener JD,DeGirolami U

subject

Has Abstract

pub_date

1982-10-01 00:00:00

pages

477-81

issue

4

eissn

0148-396X

issn

1524-4040

journal_volume

11

pub_type

杂志文章
  • Risk-to-Benefit Ratio of Venous Thromboembolism Prophylaxis for Neurosurgical Procedures at a Quaternary Referral Center.

    abstract:BACKGROUND:Pharmacological prophylaxis for venous thromboembolism (VTE) in the neurosurgical population is still a matter of debate, as the risk-to-benefit ratio is not well defined. OBJECTIVE:To further evaluate the risk-to-benefit ratio of VTE prophylaxis (VTEP) for all neurosurgical procedures. METHODS:A prospecti...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyy035

    authors: Agarwal N,Zenonos GA,Agarwal P,Walch FJ,Roach E,Stokes SJ,Friedlander RM,Gerszten PC

    更新日期:2019-02-01 00:00:00

  • Regional changes in central nervous system thyrotropin-releasing hormone after pentylenetetrazol-induced seizures in dogs.

    abstract::We have recently shown that seizures induce significant and sustained elevations of thyrotropin-releasing hormone (TRH) in specific extrahypothalamic rat brain regions associated with epileptic foci including amygdala, hippocampus, pyriform cortex, and anterior cortex. Seizures were induced in dogs to further study th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199211000-00017

    authors: Shapiro S,Kubek M,Sanders S,Durbin S,Goodwin S,Javed T

    更新日期:1992-11-01 00:00:00

  • Closure of myelorachischisis defects with reverse latissimus dorsi myocutaneous flaps.

    abstract::The closure of myelorachischisis defects has been difficult and at times complicated. Over the past 2 decades, the use of rotational advancement flaps has been increasingly popular, but can be attended by instances of skin ischemia and necrosis. The development of the myocutaneous and muscle flap concept has aided rec...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198209000-00015

    authors: Clark DH,Walsh JW,Luce EA

    更新日期:1982-09-01 00:00:00

  • The dopaminergic nigrostriatal system and Parkinson's disease: molecular events in development, disease, and cell death, and new therapeutic strategies.

    abstract::For several decades, the clinical study of Parkinson's disease has driven an increasingly sophisticated understanding of the dopaminergic system and its complex role in modulating motor behavior. This article reviews salient areas of research in this field, commencing with the molecular biology of the development of t...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000249209.11967.CB

    authors: Hodaie M,Neimat JS,Lozano AM

    更新日期:2007-01-01 00:00:00

  • Plate fixation of odontoid fractures without C1-C2 arthrodesis: practice of a novel surgical technique for stabilization of odontoid fractures, including the opportunity to extend the fixation to C3.

    abstract:OBJECTIVE:Surgical treatment of odontoid fractures that do not allow interfragmentary fracture compression involves either posterior atlantoaxial arthrodesis or additional anterior stabilization using a plate construct. The purpose of this study was to determine the clinical and radiographic outcome after anterior plat...

    journal_title:Neurosurgery

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1227/01.NEU.0000339117.60613.8C

    authors: Platzer P,Thalhammer G,Krumboeck A,Schuster R,Kutscha-Lissberg F,Zehetgruber I,Braunsteiner T,Vécsei V

    更新日期:2009-04-01 00:00:00

  • Postembolization neurological deficits in cerebral arteriovenous malformations: stratification by arteriovenous malformation grade.

    abstract:OBJECTIVE:To stratify the risk of embolization during the treatment of cerebral arteriovenous malformations (AVMs) by grade and to assess its impact on the overall treatment risk. METHODS:Patients with cerebral AVMs treated with embolization between 1995 and 2004 were retrospectively reviewed. Age, sex, AVM grade, loc...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000219219.97287.91

    authors: Kim LJ,Albuquerque FC,Spetzler RF,McDougall CG

    更新日期:2006-07-01 00:00:00

  • Treatment of acute focal cerebral ischemia with dimethyl sulfoxide.

    abstract::The object of this investigation was to study the effects of dimethyl sulfoxide (DMSO) upon the evolution of cerebral infarction. Twenty adult cats anesthetized lightly with ketamine hydrochloride underwent right middle cerebral artery occlusion for 6 hours. Ten cats were not treated and 10 cats received DMSO (2.5 g/k...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198107000-00006

    authors: Little JR,Cook A,Lesser RP

    更新日期:1981-07-01 00:00:00

  • Transient hyperemia immediately after rapid decompression of chronic subdural hematoma.

    abstract:OBJECTIVE:Intracerebral hemorrhage occurring after removal of a chronic subdural hematoma (CSH) is a rare but usually devastating postoperative complication. In patients with CSH, we determined cerebral blood flow immediately after surgical decompression to clarify the pathogenic mechanism of this complication. METHOD...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199909000-00014

    authors: Ogasawara K,Koshu K,Yoshimoto T,Ogawa A

    更新日期:1999-09-01 00:00:00

  • Familial cerebral aneurysms: a study of 13 families.

    abstract::Despite the recent interest in familial cerebral aneurysms, the epidemiology, natural history, pattern of inheritance, screening of asymptomatic relatives, and the search for a biochemical marker remain problematic. To assess these issues, we report the results of our prospective study of 30 patients with 38 aneurysms...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199510000-00005

    authors: Leblanc R,Melanson D,Tampieri D,Guttmann RD

    更新日期:1995-10-01 00:00:00

  • Gamma knife radiosurgery for cerebellopontine angle meningiomas: a multicenter study.

    abstract:BACKGROUND:Resection of cerebellopontine angle (CPA) meningiomas may result in significant neurological morbidity. Radiosurgery offers a minimally invasive alternative to surgery. OBJECTIVE:To evaluate, in a multicenter cohort study, the outcomes of patients harboring CPA meningiomas who underwent Gamma Knife radiosur...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.1227/NEU.0000000000000480

    authors: Ding D,Starke RM,Kano H,Nakaji P,Barnett GH,Mathieu D,Chiang V,Omay SB,Hess J,McBride HL,Honea N,Lee JY,Rahmathulla G,Evanoff WA,Alonso-Basanta M,Lunsford LD,Sheehan JP

    更新日期:2014-10-01 00:00:00

  • Phrenology in the science and culture of the 19th century.

    abstract::In the last decade of the 18th century, Franz Joseph Gall of Vienna invented a combination of physiognomy and brain localization that he originally called "craniology" (the science of the head) and later called "organology" (the science of the organs of the brain). Between 1800 and 1812, he worked with Johann Christop...

    journal_title:Neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1227/00006123-199510000-00025

    authors: Greenblatt SH

    更新日期:1995-10-01 00:00:00

  • Measurement of cortical microcirculation during intracranial aneurysm surgery by combined laser-Doppler flowmetry and photospectrometry.

    abstract:BACKGROUND:Accidental vessel occlusion is one major risk of intracranial aneurysm surgery potentially causing cerebral ischemia. The intraoperative assessment of cerebral ischemia remains a technological challenge. OBJECTIVE:As a novel approach, cortical tissue integrity was monitored using simultaneous measurements o...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3182178bc9

    authors: Klein KU,Stadie A,Fukui K,Schramm P,Werner C,Oertel J,Engelhard K,Fischer G

    更新日期:2011-08-01 00:00:00

  • Ranging accuracy test of the sonic microstereometric system.

    abstract::We have recently introduced a new type of ultrasonic-based, three-dimensional ranging system for the localization of small handheld surgical tools to be used during operation in open stereotactic brain surgery. This targeting system has now been extensively laboratory tested during thousands of measuring cycles with a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199404000-00030

    authors: Horstmann GA,Reinhardt HF

    更新日期:1994-04-01 00:00:00

  • Stereotactic radiosurgery improves locomotor recovery after spinal cord injury in rats.

    abstract:OBJECTIVE:Currently, because of the precision of stereotactic radiosurgery, radiation can now be delivered by techniques that shape the radiation beam to the tissue target for a variety of clinical applications. This avoids unnecessary and potentially damaging irradiation of surrounding tissues inherent in conventional...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000330404.37092.3E

    authors: Zeman RJ,Wen X,Ouyang N,Rocchio R,Shih L,Alfieri A,Moorthy C,Etlinger JD

    更新日期:2008-11-01 00:00:00

  • Boron neutron capture therapy of brain tumors: an emerging therapeutic modality.

    abstract::Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10, a stable isotope, is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei. For BNCT to be successful, a large number of 10B atoms must be localized on or preferably within neo...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199903000-00001

    authors: Barth RF,Soloway AH,Goodman JH,Gahbauer RA,Gupta N,Blue TE,Yang W,Tjarks W

    更新日期:1999-03-01 00:00:00

  • On the report of the first successful surgical treatment of brain abscess in the Ottoman Empire by Dr. Cemil Topuzlu in 1891.

    abstract::IN 1891, Dr. Cemil Topuzlu operated on a brain abscess that originated as a complication of a depression fracture of the cranial inner table. The patient presented with Jacksonian seizures on his left side after a sharp trauma resulting in a 15 cm-long scalp laceration and underlying linear cranial fracture in the rig...

    journal_title:Neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1227/01.NEU.0000298917.17001.88

    authors: Mut M,Dinç G,Naderi S

    更新日期:2007-10-01 00:00:00

  • Carpal tunnel syndrome: correlation of magnetic resonance imaging, clinical, electrodiagnostic, and intraoperative findings.

    abstract::We undertook a prospective study of 43 wrists in 32 patients who had been clinically diagnosed as having carpal tunnel syndrome (study group) and 5 wrists in people who had no symptoms (control group), correlating the clinical, electrodiagnostic, intraoperative, and magnetic resonance imaging (MRI) findings. MRI of th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199512000-00009

    authors: Britz GW,Haynor DR,Kuntz C,Goodkin R,Gitter A,Kliot M

    更新日期:1995-12-01 00:00:00

  • Granulocytic sarcoma presenting as an epidural mass with cord compression.

    abstract::Granulocytic sarcoma (GS) usually occurs during the course of, or as a presenting sign of myelogenous leukemia. Rarely it is found before peripheral blood or bone marrow evidence of leukemia is present. We describe a man who presented with low back pain and lower extremity weakness. He had spinal cord compression due ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198901000-00024

    authors: Ripp DJ,Davis JW,Rengachary SS,Lotuaco LG,Watanabe IS

    更新日期:1989-01-01 00:00:00

  • Assessment of flow in perforating arteries during intracranial aneurysm surgery using intraoperative near-infrared indocyanine green videoangiography.

    abstract:OBJECTIVE:Perforating arteries are commonly involved during the surgical dissection and clipping of intracranial aneurysms. Occlusion of perforating arteries is responsible for ischemic infarction and poor outcome. The goal of this study is to describe the usefulness of near-infrared indocyanine green videoangiography ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000333795.21468.d4

    authors: de Oliveira JG,Beck J,Seifert V,Teixeira MJ,Raabe A

    更新日期:2008-06-01 00:00:00

  • MIB-1 staining index of pediatric meningiomas.

    abstract:OBJECTIVE:For adult meningiomas, the staining index (SI) for the anti-Ki-67 monoclonal antibody MIB-1 is well correlated with histological atypia and tumor recurrence. MIB-1 SIs for meningiomas in the pediatric population have not been previously reported. Meningiomas tend to be more histologically aggressive and to re...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200103000-00027

    authors: Sandberg DI,Edgar MA,Resch L,Rutka JT,Becker LE,Souweidane MM

    更新日期:2001-03-01 00:00:00

  • Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans.

    abstract:OBJECTIVE:Uncoupling of cerebral blood flow (CBF) and oxidative metabolism is observed after severe head injury in comatose patients; however, the mechanism(s) involved remain undefined. Adenosine can produce cerebral vasodilation and reduce neuronal activity and is a possible mediator of uncoupling. We hypothesized th...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199712000-00010

    authors: Clark RS,Carcillo JA,Kochanek PM,Obrist WD,Jackson EK,Mi Z,Wisneiwski SR,Bell MJ,Marion DW

    更新日期:1997-12-01 00:00:00

  • Traumatic indirect carotid-cavernous fistula: report of two cases.

    abstract:UNLABELLED:OBJECTIVE AND CLINICAL IMPORTANCE: We present two cases of post-traumatic indirect carotid-cavernous fistulas. Trauma produces the direct type of carotid-cavernous fistula in almost all cases, and recognition that trauma may induce the indirect type has been rarely reported. CLINICAL PRESENTATION:Both patie...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199612000-00033

    authors: Jacobson BE,Nesbit GM,Ahuja A,Barnwell SL

    更新日期:1996-12-01 00:00:00

  • Pituitary adenomas with invasion of the cavernous sinus space: a magnetic resonance imaging classification compared with surgical findings.

    abstract::We present 25 pituitary adenomas that were confirmed surgically to have invaded the cavernous sinus space. The surgical results are compared with the preoperative magnetic resonance imaging findings. For comparable radiological criteria, we classified parasellar growth into five grades. This proposed classification is...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199310000-00008

    authors: Knosp E,Steiner E,Kitz K,Matula C

    更新日期:1993-10-01 00:00:00

  • Pseudotumor syndrome resulting from a cerebral arteriovenous malformation: case report.

    abstract::We report a case of a cerebral arteriovenous malformation presenting as a pseudotumor cerebri syndrome. The lack of mass effect, hemorrhage, or hydrocephalus, in addition to angiographic evidence of high-flow and venous outflow restriction, implicate increased cerebral blood flow and venous hypertension as the mechani...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/00006123-199503000-00020

    authors: David CA,Peerless SJ

    更新日期:1995-03-01 00:00:00

  • Stent-assisted coiling of wide-necked aneurysms in the setting of acute subarachnoid hemorrhage: experience in 65 patients.

    abstract:BACKGROUND:Stent-assisted coiling in the setting of subarachnoid hemorrhage remains controversial. Currently, there is a paucity of data regarding the utility of this procedure and the risks of hemorrhagic and ischemic complications. OBJECTIVE:To assess the utility of stent-assisted coil embolization and pretreatment ...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318246a4b1

    authors: Amenta PS,Dalyai RT,Kung D,Toporowski A,Chandela S,Hasan D,Gonzalez LF,Dumont AS,Tjoumakaris SI,Rosenwasser RH,Maltenfort MG,Jabbour PM

    更新日期:2012-06-01 00:00:00

  • Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.

    abstract:BACKGROUND:Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group. OBJECTIVE:To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms. METHODS:Intrac...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000528

    authors: Tada Y,Makino H,Furukawa H,Shimada K,Wada K,Liang EI,Murakami S,Kudo M,Kung DK,Hasan DM,Kitazato KT,Nagahiro S,Lawton MT,Hashimoto T

    更新日期:2014-12-01 00:00:00

  • Intracranial aneurysms and sickle cell anemia: multiplicity and propensity for the vertebrobasilar territory.

    abstract:OBJECTIVE:We describe a case of sickle cell anemia and multiple intracranial aneurysms and review the English-language-reported cases of sickle cell disease associated with intracranial aneurysms proven angiographically or by autopsy, to assess whether there are associations with aneurysm multiplicity and sites of aneu...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199805000-00007

    authors: Preul MC,Cendes F,Just N,Mohr G

    更新日期:1998-05-01 00:00:00

  • Cystic glioma of the brain stem with prolonged survival.

    abstract::An unusual case of benign stem glioma with a 15-year survival is presented. In spite of 12 years of clinical quiescence, a focus of the tumor in the upper brain stem was found at necropsy. Morphologically, the tumor was a cystic pilocytic astrocytoma. The few previously reported similar cases in the same location were...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198204000-00015

    authors: Soffer D,Sahar A

    更新日期:1982-04-01 00:00:00

  • Treatment of cerebrospinal fluid and syringosubarachnoid shunt infection with systemic and intrathecal antibiotics.

    abstract::We present a case of a patient with two preexisting Silastic syringosubarachnoid shunt catheters who developed Enterobacter meningitis. The infection was treated successfully with systemic and intrathecal antibiotics without removal of the catheters. With careful sequential clinical and laboratory monitoring, even thi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198508000-00015

    authors: Tomaszek DE,Powers SK

    更新日期:1985-08-01 00:00:00

  • Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes.

    abstract:BACKGROUND:Resection is a critical component in the initial treatment of glioblastoma (GBM). Often GBMs are resected using an intralesional method. Circumferential perilesional resection of GBMs has been described, but with limited data. OBJECTIVE:To conduct an observational retrospective analysis to test whether peri...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1093/neuros/nyz008

    authors: Al-Holou WN,Hodges TR,Everson RG,Freeman J,Zhou S,Suki D,Rao G,Ferguson SD,Heimberger AB,McCutcheon IE,Prabhu SS,Lang FF,Weinberg JS,Wildrick DM,Sawaya R

    更新日期:2020-01-01 00:00:00