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Analysis of gene duplication repeats in the myosin rod.

Abstract：

:The helical coiled-coil region of the myosin rod in the nematode Caenorhabditis elegans is a repetitive sequence 1094 amino acids long which contains 39 repeats of a 28-residue pattern. The repeats are extremely significant when compared with the statistical distributions expected, first for random sequences, and then for sequences with a typical seven-residue coiled-coil periodicity. New and improved statistical tests are used. The repeats are stronger in the first 350 residues of the rod (fragment S-2) than in the remainder. The corresponding DNA sequence of the unc-54 gene shows the same features, but they are less significant when judged by the number of identical bases than are the amino acid similarities, as measured by Dayhoff scores. The rod sequence shows strong evidence for a longer repeat unit of 196 residues, which may be related to the cross-bridge spacing of 143 A in muscle.

journal_name

J Mol Biol

journal_title

Journal of molecular biology

authors

McLachlan AD

doi

10.1016/s0022-2836(83)80173-9

subject

Has Abstract

pub_date

1983-09-05 00:00:00

pages

15-30

issue

1

eissn

0022-2836

issn

1089-8638

pii

S0022-2836(83)80173-9

journal_volume

169

pub_type

杂志文章

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