A monoclonal antibody against a new differentiation antigen of thymocytes.

abstract：:CBA/N mice have an X-linked immune defect in B lymphocyte function which leads to their inability to respond to several thymus-independent antigens. We report here that these mice and immunologically defective F1 male (CBA/N X DBA/2N) mice can respond to Brucella abortus and to 2,4,6-trinitrophenyl derivatives of Bruc...

journal_title：European journal of immunology

authors： Mond JJ,Scher I,Mosier DE,Baese M,Paul WE

更新日期：1978-07-01 00:00:00

abstract：:The CD4 T cell surface molecule binds MHC class II determinants expressed on antigen-presenting cells. CD4 is thought to enhance T cell activation by serving as an adhesion molecule as well as possibly by transducing an independent intracellular signal during the process of antigen stimulation. The recent observation ...

journal_title：European journal of immunology

authors： Veillette A,Sleckman BP,Ratnofsky S,Bolen JB,Burakoff SJ

更新日期：1990-06-01 00:00:00

abstract：:Dendritic cells (DCs) are essential in dictating the nature and effectiveness of immune responses. In the intestine DCs can be separated into discrete subsets, defined by expression of CD11b and CD103, each with different developmental requirements and distinct functional potential. Recent evidence has shown that diff...

journal_title：European journal of immunology

authors： Redpath SA,Heieis GA,Reynolds LA,Fonseca NM,Kim SS,Perona-Wright G

更新日期：2018-01-01 00:00:00

abstract：:The crucial role of interleukin (IL)-4 in the induction of murine IgG1 and IgE responses, which are coupled through the process of sequential isotype switching, has been well documented. Whereas IL-4 is obligatory for the induction of IgE responses, it enhances IgG1 responses. In this study, using neutralizing antibod...

journal_title：European journal of immunology

authors： van Ommen R,Vredendaal AE,Savelkoul HF

更新日期：1994-06-01 00:00:00

abstract：:Vitamin A deficiency is known to be accompanied with immune deficiency and susceptibility to a wide range of infectious diseases. Experimental evidence suggests that the active metabolites of vitamin A that mediate its effects on the immune system are the retinoic acids (RA), which are ligands for the nuclear RA recep...

journal_title：European journal of immunology

authors： Kiss I,Rühl R,Szegezdi E,Fritzsche B,Tóth B,Pongrácz J,Perlmann T,Fésüs L,Szondy Z

更新日期：2008-01-01 00:00:00

abstract：:An effective immune response against the intracellular pathogen Mycobacterium tuberculosis is strictly dependent on T cell activation. Although this protective response mainly depends on local release of pro-inflammatory cytokines by Th1 CD4(+) T cells, contribution of Vgamma9 / Vdelta2 T lymphocytes to immune protect...

journal_title：European journal of immunology

authors： Dieli F,Troye-Blomberg M,Ivanyi J,Fournié JJ,Bonneville M,Peyrat MA,Sireci G,Salerno A

更新日期：2000-05-01 00:00:00

abstract：:To investigate the role of interferon-gamma (IFN-gamma) in experimental autoimmune thyroidits (EAT), H-2k mice with a disrupted IFN-gamma receptor (IFN-gamma R) gene were immunized with porcine thyroglobulin (pTg). We observed that EAT occurred on day 19 and remitted on day 35 in IFN-gamma R-deficient (IFN-gamma R(0/0...

journal_title：European journal of immunology

authors： Alimi E,Huang S,Brazillet MP,Charreire J

更新日期：1998-01-01 00:00:00

abstract：:Membrane-bound immunoglobulins of the IgM and IgD class are expressed on the B cell surface in association with a disulfide-linked heterodimer consisting of alpha and beta subunits. While the alpha component of the IgM antigen receptor (IgM-alpha, 34 kDa) is encoded by the B cell-specific gene mb-1, the gene coding fo...

journal_title：European journal of immunology

authors： Wienands J,Reth M

更新日期：1991-10-01 00:00:00

abstract：:Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a familial hemophagocytic lymphohistio-cytosis, we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtain...

journal_title：European journal of immunology

authors： D'Orlando O,Zhao F,Kasper B,Orinska Z,Müller J,Hermans-Borgmeyer I,Griffiths GM,Zur Stadt U,Bulfone-Paus S

更新日期：2013-01-01 00:00:00

abstract：:Lipoproteins or lipopeptides (LP) are bacterial cell wall components detected by the innate immune system. For LP, it has been shown that TLR2 is the essential receptor in cellular activation. However, molecular mechanisms of LP recognition are not yet clear. We used a FLAG-labeled derivative of the synthetic lipopept...

journal_title：European journal of immunology

authors： Manukyan M,Triantafilou K,Triantafilou M,Mackie A,Nilsen N,Espevik T,Wiesmüller KH,Ulmer AJ,Heine H

更新日期：2005-03-01 00:00:00

abstract：:Mouse B cells cultured with either phorbol myristate acetate (PMA), or with Ca2+ ionophores enter a transitional activated state, between quiescence (G0) and G1, but do not synthesize DNA. It is shown here that the combination of PMA plus the ionophore ionomycin induces resting B cells to synthesize DNA, but not to se...

journal_title：European journal of immunology

authors： Klaus GG,O'Garra A,Bijsterbosch MK,Holman M

更新日期：1986-01-01 00:00:00

abstract：:Human cytomegalovirus (HCMV) employs multiple mechanisms to evade the immune system and succeeds to persist lifelong in the host. Human dendritic cells (DC) are the main antigen-presenting cells and play the key role in inducing and maintaining immune responses. Here, we studied the interaction of HCMV with DC. We fou...

journal_title：European journal of immunology

authors： Beck K,Meyer-König U,Weidmann M,Nern C,Hufert FT

更新日期：2003-06-01 00:00:00

abstract：:Limited studies have addressed the ability of gammadelta T cells to become memory populations. We previously demonstrated that WC1.1(+) gammadelta T cells from ruminants vaccinated with killed Leptospira borgpetersenii proliferate and produce IFN-gamma in recall responses. Here we show that this response is dependent ...

journal_title：European journal of immunology

authors： Blumerman SL,Herzig CT,Baldwin CL

更新日期：2007-05-01 00:00:00

abstract：:Leishmania-induced macrophage (Mphi) dysfunctions have been correlated with altered signaling events. Recent findings from our laboratory suggest that modulation of host protein tyrosine phosphatase (PTP) following Leishmania infection could lead to these Mphi defects. To address this issue, Mphi PTP activity and IFN-...

journal_title：European journal of immunology

authors： Blanchette J,Racette N,Faure R,Siminovitch KA,Olivier M

更新日期：1999-11-01 00:00:00

abstract：:In this study, we demonstrated that antibodies reactive with a common beta 1 subunit (CD29) of the VLA family of antigens could synergize with CD3 but not CD2 in inducing CD4 cell proliferation in a serum-free culture system. The extent of activation was similar to that obtained when CD4 cells were cultured with anti-...

journal_title：European journal of immunology

authors： Yamada A,Nojima Y,Sugita K,Dang NH,Schlossman SF,Morimoto C

更新日期：1991-02-01 00:00:00

abstract：:In M54 mice transgenic for a completely rearranged mu(a) heavy chain there is a decrease in total B cells and the rearrangement of endogenous immunoglobulin genes is partially inhibited. Surprisingly, however, endogenous immunoglobulin gene rearrangement and significant heavy chain polypeptide production does occur. W...

journal_title：European journal of immunology

authors： Rabin E,Cong Y,Imanishi-Kari T,Wortis HH

更新日期：1992-09-01 00:00:00

abstract：:Murine Thy-1+, TcR V gamma 3/V delta 1+ dendritic epidermal T cells (DETC) differ from most other T cell subsets by the absence of CD4 and CD8 antigens as well as the lack of CD5 expression. To see whether negativity for those antigens is an intrinsic feature of a given T cell population or if such triple-negative T c...

journal_title：European journal of immunology

authors： Payer E,Kutil R,Stingl G

更新日期：1994-06-01 00:00:00

abstract：:Thapsigargin (TG), which inhibits endoplasmic reticulum-dependent Ca(2 +)-ATPase and thereby increases cytosolic Ca(2 +), has been reported to cause apoptosis in T lymphocytes another cell types. In this study, we investigated the molecular mechanisms that are involved in the apoptosis induced by TG in T cell hybridom...

journal_title：European journal of immunology

authors： Liu W,Youn HD,Liu JO

更新日期：2001-06-01 00:00:00

abstract：:F protein is found predominantly in the liver and is of unknown function. The protein has been of interest to immunologists in the areas of self tolerance and the immunogenetics of the anti-F protein response. In the mouse there are two alleles (F1 and F2), and although mice are completely tolerant to the self form of...

journal_title：European journal of immunology

authors： Schofield JP,Vijayakumar RK,Oliveira DB

更新日期：1991-05-01 00:00:00

abstract：:Surviving an infection requires the generation of an immune response that controls the invading pathogen while limiting collateral damage to self tissues that may result from an exuberant immune response. Various populations of regulatory cells, including Foxp3+ Treg, have been shown to play a central role in the esta...

journal_title：European journal of immunology

authors： Belkaid Y

更新日期：2008-04-01 00:00:00

abstract：:We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presentin...

journal_title：European journal of immunology

authors： Darji A,Stockinger B,Wehland J,Chakraborty T,Weiss S

更新日期：1997-07-01 00:00:00

abstract：:CD25+ FOXP3+CD4+ T cells (Treg) have been considered to play an important role in immune tolerance against several tumor antigens. It has also been indicated that high-level expression of FOXP3 (FOXP3high) is sufficient to confer suppressive activity to normal non-Treg. Here, we showed for the first time that vascular...

journal_title：European journal of immunology

authors： Suzuki H,Onishi H,Wada J,Yamasaki A,Tanaka H,Nakano K,Morisaki T,Katano M

更新日期：2010-01-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem-cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant...

journal_title：European journal of immunology

authors： Rossignol A,Levescot A,Jacomet F,Robin A,Basbous S,Giraud C,Roy L,Guilhot F,Turhan AG,Barra A,Herbelin A,Gombert JM

更新日期：2012-07-01 00:00:00

abstract：:Bone marrow mesenchymal progenitor cells (BMSC) are used for regenerating tissues of mesodermal origin, as well as tissues of different embryological derivation. Experimental evidence shows that BMSC are able to suppress the activation of the immune response by mechanisms that are still not completely understood. Thus...

journal_title：European journal of immunology

authors： Augello A,Tasso R,Negrini SM,Amateis A,Indiveri F,Cancedda R,Pennesi G

更新日期：2005-05-01 00:00:00

abstract：:Studies of chronic viral infections have highlighted the phenotypic and functional heterogeneity of antigen-specific T cells and suggested that polyfunctional T cells that secrete multiple cytokines and are able to proliferate on encounter with antigen are more likely than single cytokine secretors to represent correl...

journal_title：European journal of immunology

authors： Wilkinson KA,Wilkinson RJ

更新日期：2010-08-01 00:00:00

abstract：:Beside diabetes, non-obese diabetic (NOD) mice develop sporadic lymphoid infiltration of the thyroid gland, mimicking Hashimoto's thyroiditis. We have examined the prevalence of those manifestations in NOD mice, the influence of the major histocompatibility complex (MHC) and the association with autoantibodies. The in...

journal_title：European journal of immunology

authors： Damotte D,Colomb E,Cailleau C,Brousse N,Charreire J,Carnaud C

更新日期：1997-11-01 00:00:00

abstract：:The capacity of old (18-24 months) C57BL/6 mice to develop an immune reaction against MC-B6-1 fibrosarcoma cells was studied using in vivo adoptive transfer experiments (Winn assay) and in vitro T cell-mediated cytotoxicity test. Anti-tumor immunity was found to decline with age, as indicated by a decreased anti-tumor...

journal_title：European journal of immunology

authors： Bruley-Rosset M,Payelle B

更新日期：1987-03-01 00:00:00

abstract：:Young (less than 3 months of age) and old (greater than 1 year of age) C.B-17 scid/scid mice were tested for the presence of immunoglobulin in serum and CD3+ T cells in spleen and peritoneal cavity. In all old severe combined immune deficiency (scid) mice tested we found detectable, but very variable levels of serum i...

journal_title：European journal of immunology

authors： Rudolphi A,Spiess S,Conradt P,Claësson MH,Reimann J

更新日期：1991-02-01 00:00:00

abstract：:Toll-like receptors (TLR) 7 and 8 are closely related members of the TLR family of pathogen-associated molecular pattern recognition receptors and have an important function in activation of innate immune responses upon viral infection. TLR7 can be activated selectively by the guanosine analogue loxoribine, whereas th...

journal_title：European journal of immunology

authors： Jurk M,Kritzler A,Schulte B,Tluk S,Schetter C,Krieg AM,Vollmer J

更新日期：2006-07-01 00:00:00

abstract：:T cell stimulation of B cell proliferation during T-B collaboration requires membrane-bound stimulatory ligands, such as CD40 ligand and the secretion of soluble cytokines, such as IL-4. Nevertheless, it remains unclear whether T cell contact is required to provoke each consecutive B cell division, or whether B cells ...

journal_title：European journal of immunology

authors： Rush JS,Hodgkin PD

更新日期：2001-04-01 00:00:00