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Resorcinol congeners of dopamine derived from benzocycloheptene and indan.

Abstract：

:Series of N-alkylated derivatives of 2-amino-4,6-dihydroxyindan 3 and 6-amino-1,3-dihydroxybenzocycloheptene 2 were prepared for pharmacological testing as congeners of 2-amino-5,7-dihydroxytetralin, which elicits dopaminergic effects in a variety of assays. All of the subject compounds demonstrated a lower order of dopamine-like activity than the tetralin derivatives. Some of the subject compounds showed weak interactions with alpha 1- and beta 1-adrenoceptors, but the major determinant of activity seemed to be the nature of the N-alkyl substituent rather than ring size.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Cannon JG,Pease JP,Hamer RL,Ilhan M,Bhatnagar RK,Long JP

doi

10.1021/jm00368a014

subject

Has Abstract

pub_date

1984-02-01 00:00:00

pages

186-9

issue

2

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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