Abstract:
:Two nitrosourea compounds--1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)--have been used in the treatment of primary and metastatic brain tumors after operation and/or radiotherapy. Hematological and nonhematological toxicity were recorded in 272 patients treated between May 1973 and June 1978. BCNU was given to 135 patients (80 mg/m2 i.v. daily for 3 days) and CCNU was given to 137 patients (130 mg/m2 orally, single dose) every 8 weeks until progression of the primary disease process or for a total of 12 cycles. Radiation therapy (5500 +/- 500 rads in 6 to 7 weeks) was carried out after the first course of chemotherapy. BCNU and CCNU induced the same hematological and clinical toxicity. The bone marrow toxicity seemed to be dose-related, delayed, and cumulative. One case of acute nonlymphoblastic leukemia arising 2 months after the end of CCNU therapy is reported.
journal_name
Neurosurgeryjournal_title
Neurosurgeryauthors
Robustelli della Cuna G,Paoletti P,Bernardo G,Knerich R,Butti G,Cuzzoni Qdoi
10.1227/00006123-198209000-00012subject
Has Abstractpub_date
1982-09-01 00:00:00pages
408-11issue
3eissn
0148-396Xissn
1524-4040journal_volume
11pub_type
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