Initial characterization of the dosimetry and radiology of a device for administering interstitial stereotactic radiosurgery.

Abstract:

OBJECTIVE:We report the design and initial characterization of the dosimetry and radiobiology of a novel device for interstitial stereotactic radiosurgery. INSTRUMENTATION:The device is lightweight, handheld, and battery-powered, and it emits x-ray radiation from the tip of a probe 3 mm in diameter by 10 cm in length. METHODS:The dosimetry was characterized by two independent methods: thermoluminescent dosimeters and radiochromic film. The radiobiology was characterized by in vivo irradiation of rat liver, dog liver, and dog brain. The animals were killed at varying intervals of time, and histological examinations were performed. Heat transfer from the probe to dog brain was studied in vivo by placing thermocouple sensors around the probe tip before irradiating. RESULTS:Both dosimetric methods showed a steep dose-distance fall-off relationship (proportional to the reciprocal of the cube of the distance from the probe tip). Rats and dogs that were killed weeks to months after liver irradiation tended to have sharply demarcated lesions. Liver enzyme levels, measured serially in the dogs, did not give evidence of chronic inflammation. Histological examination of the brains of dogs that were killed acutely after irradiation did not show evidence of inflammation, edema, or hemorrhage. The tissue temperature elevation 1 cm from the tip never exceeded 0.5 degree C, thereby excluding hyperthermia as a significant contributor to the formation of lesions. CONCLUSIONS:Because this device requires relatively few supporting resources, has sharp dosimetric properties, and seems to be safe, it may be useful as a clinical tool for interstitial stereotactic radiosurgery.

journal_name

Neurosurgery

journal_title

Neurosurgery

authors

Hakim R,Zervas NT,Hakim F,Butler WE,Beatty J,Yanch JC,Biggs PJ,Gall KP,Sliski AP

doi

10.1097/00006123-199703000-00016

subject

Has Abstract

pub_date

1997-03-01 00:00:00

pages

510-6; discussion 516-7

issue

3

eissn

0148-396X

issn

1524-4040

journal_volume

40

pub_type

杂志文章
  • The use of electroencephalography and brain protection during operation for basilar aneurysms.

    abstract::Intraoperative monitoring with electroencephalography and the use of brain protection with steroids, phenytoin, mannitol, and pentobarbital or etomidate were evaluated in 15 patients undergoing operation for an aneurysm of the upper basilar artery. One patient harbored a basilar trunk aneurysm, 1 an aneurysm of the pr...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-198912000-00008

    authors: Muizelaar JP

    更新日期:1989-12-01 00:00:00

  • Changes in the immunophenotype of recurrent pituitary adenomas.

    abstract::Only two cases have been reported of a pituitary adenoma that changed phenotype between its initial resection and recurrence. To determine the frequency of such cases among our patients, we examined the clinical course of these tumors and characterized any patterns. We reviewed the charts of 1023 patients with pituita...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199407000-00006

    authors: Mindermann T,Kovacs K,Wilson CB

    更新日期:1994-07-01 00:00:00

  • Middle cerebral artery aneurysm due to Nocardia asteroides: case report of aneurysm excision and extracranial-intracranial bypass.

    abstract::Nocardia asteroides is an uncommon human pathogen typically encountered in immunocompromised patients. Primary central nervous system (CNS) nocardiosis is rare and usually manifests as cerebritis or abscesses. The case of a young woman who presented with CNS Nocardia abscesses complicated by an infective middle cerebr...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Hadley MN,Spetzler RF,Martin NA,Johnson PC

    更新日期:1988-05-01 00:00:00

  • Anatomical study of the superficial temporal artery.

    abstract::Fifty consecutive human autopsy specimens were studied to determine the suitability of the superficial temporal artery (STA) for use in microvascular anastomoses. Ten variations of the STA were found. The STA at the zygoma averaged 2.2 mm in outside diameter. The STA averaged 31.7 mm from the zygoma to its bifurcation...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198506000-00008

    authors: Marano SR,Fischer DW,Gaines C,Sonntag VK

    更新日期:1985-06-01 00:00:00

  • Anosmia after anterior communicating artery aneurysm surgery: comparison between the anterior interhemispheric and basal interhemispheric approaches.

    abstract::The olfactory function could be examined in 101 of 138 patients with anterior communicating artery aneurysms, whom we treated during a recent 6-year period. Among them, 49 patients underwent surgery by the anterior interhemispheric approach and 52 underwent surgery by the basal interhemispheric approach. Fifteen patie...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199602000-00017

    authors: Fujiwara H,Yasui N,Nathal-Vera E,Suzuki A

    更新日期:1996-02-01 00:00:00

  • Intraoperative Near-Infrared Optical Imaging Can Localize Gadolinium-Enhancing Gliomas During Surgery.

    abstract:BACKGROUND:Although real-time localization of gliomas has improved with intraoperative image guidance systems, these tools are limited by brain shift, surgical cavity deformation, and expense. OBJECTIVE:To propose a novel method to perform near-infrared (NIR) imaging during glioma resections based on preclinical and c...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000001450

    authors: Lee JY,Thawani JP,Pierce J,Zeh R,Martinez-Lage M,Chanin M,Venegas O,Nims S,Learned K,Keating J,Singhal S

    更新日期:2016-12-01 00:00:00

  • The morning visit by Oliver Wendell Holmes, Sr., M.D.

    abstract::Today, physicians in general and neurosurgeons in particular practice in an era of fundamental change in Medicine from a profession to an industry. This change has produced erosion in the very personal physician-patient relationship. "The Morning Visit" is a poem written by Oliver Wendell Holmes, Sr., M.D., a 19th cen...

    journal_title:Neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.1227/01.NEU.0000351280.04013.65

    authors: Ciric IS

    更新日期:2009-10-01 00:00:00

  • Market-Based Health Care in Specialty Surgery: Finding Patient-Centered Shared Value.

    abstract::: The US health care system is struggling with rising costs, poor outcomes, waste, and inefficiency. The Patient Protection and Affordable Care Act represents a substantial effort to improve access and emphasizes value-based care. Value in health care has been defined as health outcomes for the patient per dollar spen...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/NEU.0000000000000879

    authors: Smith TR,Rambachan A,Cote D,Cybulski G,Laws ER

    更新日期:2015-10-01 00:00:00

  • Intracranial meningiomas in the aged: surgical outcome in the era of computed tomography.

    abstract::Seventy-five patients older than 60 years of age underwent surgical resection of intracranial meningiomas during a 10-year period at a single institution. All patients had a computed tomographic scan preoperatively, and all were followed for at least 3 months postoperatively. There were 50 patients 61 to 70 years of a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198904000-00011

    authors: Awad IA,Kalfas I,Hahn JF,Little JR

    更新日期:1989-04-01 00:00:00

  • Perioperative fever and outcome in surgical patients with aneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:We examined the incidence of perioperative fever and its relationship to outcome among patients enrolled in the Intraoperative Hypothermia for Aneurysm Surgery Trial. METHODS:One thousand patients with initial World Federation of Neurological Surgeons grades of I to III undergoing clipping of intracranial an...

    journal_title:Neurosurgery

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1227/01.NEU.0000341903.11527.2F

    authors: Todd MM,Hindman BJ,Clarke WR,Torner JC,Weeks JB,Bayman EO,Shi Q,Spofford CM,IHAST Investigators.

    更新日期:2009-05-01 00:00:00

  • Pre- and intraoperative tractographic evaluation of corticospinal tract shift.

    abstract:BACKGROUND:Magnetic resonance with diffusion tensor image (DTI) may be able to estimate trajectories compatible with subcortical tracts close to brain lesions. A limit of DTI is brain shifting (movement of the brain after dural opening and tumor resection). OBJECTIVE:To calculate the brain shift of trajectories compat...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e31821a8555

    authors: Romano A,D'Andrea G,Calabria LF,Coppola V,Espagnet CR,Pierallini A,Ferrante L,Fantozzi L,Bozzao A

    更新日期:2011-09-01 00:00:00

  • Guest Editorial: An Update on Stroke Intervention.

    abstract::Endovascular treatment for acute ischemic stroke has changed remarkably over the past decade. Beginning with IA thrombolytic administration, endovascular strategies have evolved to include aspiration, self-expanding intracranial stents, and now retrievable stents. With the recent publication of 5 randomized, controlle...

    journal_title:Neurosurgery

    pub_type: 社论

    doi:10.1227/NEU.0000000000000828

    authors: Munich SA,Mokin M,Snyder KV,Siddiqui AH,Hopkins LN,Levy EI

    更新日期:2015-09-01 00:00:00

  • Extracranial-intracranial vein graft bypass for giant intracranial aneurysm surgery for pediatric patients: two technical case reports.

    abstract:OBJECTIVE AND IMPORTANCE:Herein we describe two cases of extracranial-intracranial vein graft bypasses for the treatment of giant intracranial aneurysms in prepubertal pediatric patients. One patient is, we think, the youngest patient reported in the literature to have been successfully treated in such a manner, with a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200203000-00048

    authors: Zhang YJ,Barrow DL,Day AL

    更新日期:2002-03-01 00:00:00

  • Preoperative imaging to predict intraoperative changes in tumor-to-corticospinal tract distance: an analysis of 45 cases using high-field intraoperative magnetic resonance imaging.

    abstract:BACKGROUND:Preoperative diffusion tensor imaging (DTI) is used to demonstrate corticospinal tract (CST) position. Intraoperative brain shifts may limit preoperative DTI value, and studies characterizing such shifts are lacking. OBJECTIVE:To examine tumor characteristics that could predict intraoperative shift in tumor...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0000000000000338

    authors: Shahar T,Rozovski U,Marko NF,Tummala S,Ziu M,Weinberg JS,Rao G,Kumar VA,Sawaya R,Prabhu SS

    更新日期:2014-07-01 00:00:00

  • Familial cerebral aneurysms: a study of 13 families.

    abstract::Despite the recent interest in familial cerebral aneurysms, the epidemiology, natural history, pattern of inheritance, screening of asymptomatic relatives, and the search for a biochemical marker remain problematic. To assess these issues, we report the results of our prospective study of 30 patients with 38 aneurysms...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-199510000-00005

    authors: Leblanc R,Melanson D,Tampieri D,Guttmann RD

    更新日期:1995-10-01 00:00:00

  • Choroidal epithelial cyst of the prepontine region: case report and ultrastructural study.

    abstract::A case of choroidal epithelial cyst of the prepontine region is reported. The cyst wall was studied using light and electron microscopy. Electron microscopy revealed that the lining of the cyst consisted of a single layer of epithelial cells resting on a basement membrane. The epithelial cells contained numerous club-...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198801010-00021

    authors: Fukushima T,Hirakawa T,Tanaka A,Tomonaga M

    更新日期:1988-01-01 00:00:00

  • New head-positioning system for use with computed tomographic scanning.

    abstract::A new head-positioning system has been developed to hold the head firmly during the performance of a computed tomograhic scan and to position the head reproducibly during repeat scans. This can be used to maintain the head in position during long scanning sessions, to relate a lesion to landmarks on scout views, to fo...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198008000-00006

    authors: Kaufman HH,Gildenberg PL

    更新日期:1980-08-01 00:00:00

  • Familial colloid cyst of the third ventricle: case report and review of associated conditions.

    abstract::The cases of a father and his son who were diagnosed with pathologically confirmed colloid cysts of the third ventricle are presented. The familial occurrence of this tumor is rare and suggests that genetic factors may play a role in its formation. Consistent with the concept that the cyst originates as a developmenta...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1097/00006123-199602000-00033

    authors: Akins PT,Roberts R,Coxe WS,Kaufman BA

    更新日期:1996-02-01 00:00:00

  • Neonatal ventriculosubgaleal shunts.

    abstract:OBJECTIVE:We report on 32 neonates treated with ventriculosubgaleal (VSG) shunts to determine VSG shunt survival and associated complications. METHODS:Between 1993 and 1997, 37 VSG shunts were placed in 32 neonates when the cerebrospinal fluid (CSF) or the abdomen was considered unsuitable for ventriculoperitoneal shu...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200007000-00018

    authors: Fulmer BB,Grabb PA,Oakes WJ,Mapstone TB

    更新日期:2000-07-01 00:00:00

  • Combination of functional magnetic resonance imaging-guided neuronavigation and intraoperative cortical brain mapping improves targeting of motor cortex stimulation in neuropathic pain.

    abstract:OBJECTIVE:To evaluate, regardless of the clinical results, the contribution of combining functional magnetic resonance imaging (fMRI) with intraoperative cortical brain mapping (iCM) as functional targeting methods for epidural chronic motor cortex stimulation (MCS) in refractory neuropathic pain. METHODS:Eighteen neu...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.neu.0000333762.38500.ac

    authors: Pirotte B,Voordecker P,Neugroschl C,Baleriaux D,Wikler D,Metens T,Denolin V,Joffroy A,Massager N,Brotchi J,Levivier M

    更新日期:2008-06-01 00:00:00

  • Microvascular decompression for tinnitus: significant improvement for tinnitus intensity without improvement for distress. A 4-year limit.

    abstract:OBJECTIVE:Microvascular compressions of the cochlear nerve can lead to tinnitus. The tinnitus initially is related to nonsynchronous signal transmission in the auditory nerve, neurophysiologically characterized by a peak II amplitude decrease. Chronic compression can lead to a focal demyelination, resulting in an incre...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/01.NEU.0000366110.87836.53

    authors: De Ridder D,Vanneste S,Adriaenssens I,Lee AP,Plazier M,Menovsky T,van der Loo E,Van de Heyning P,Møller A

    更新日期:2010-04-01 00:00:00

  • Computer-aided intelligence: application of an expert system to brachial plexus injuries.

    abstract::When confronted with a patient with a brachial plexus injury, how often as neurosurgeons do we consult an atlas to confirm the anatomy of the brachial plexus and then attempt to establish the location of the lesion? Similar difficulties are encountered with lumbar and sacral plexus lesions. In a project organized to a...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:

    authors: Fisher WS 3rd

    更新日期:1990-11-01 00:00:00

  • Chiari I malformation with traumatic syringomyelia and spontaneous resolution: case report and literature review.

    abstract::A case history of a 28-year-old woman who sustained a moderately severe head injury and then developed acute bilateral arm weakness is presented. Magnetic resonance imaging studies revealed a Chiari I malformation with a large cervical syringomyelia (hydromyelia). The patient's arm weakness almost completely resolved ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:

    authors: Olivero WC,Dinh DH

    更新日期:1992-05-01 00:00:00

  • Repeat transsphenoidal surgery for the treatment of remaining or recurring pituitary tumors in acromegaly.

    abstract:BACKGROUND:Acromegaly is a disorder characterized by hypersecretion of growth hormone caused by a growth hormone-secreting pituitary adenoma. OBJECTIVE:To evaluate the long-term efficacy and safety of repeat transsphenoidal surgery for persistent or recurrent acromegaly. METHODS:We retrospectively reviewed records fo...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e3181ec4379

    authors: Yamada S,Fukuhara N,Oyama K,Takeshita A,Takeuchi Y

    更新日期:2010-10-01 00:00:00

  • The effect of timing of intrathecal fibrinolytic therapy on cerebral vasospasm in a primate model of subarachnoid hemorrhage.

    abstract::The effect of intrathecal tissue plasminogen activator administered at times from 0 to 72 hours after subarachnoid hemorrhage on the development of cerebral vasospasm in primates was examined. Thirty monkeys were randomly assigned into one of five equal groups: a control group that underwent subarachnoid hemorrhage al...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-199002000-00003

    authors: Findlay JM,Weir BK,Kanamaru K,Grace M,Baughman R

    更新日期:1990-02-01 00:00:00

  • What factors are related to impairment of cerebrovascular reserve before and after arteriovenous malformation resection? A cerebral blood flow study using xenon-enhanced computed tomography.

    abstract:OBJECTIVE:To examine the incidence and possible determinants of impaired vascular reserve in arteriovenous malformation (AVM)-affected brain, before and after surgery. METHODS:In a prospective study of 30 patients, the regional cerebrovascular reserve capacity (rCRC) and the vasodilated regional cerebral blood flow (r...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1097/00006123-200104000-00001

    authors: Van Roost D,Schramm J

    更新日期:2001-04-01 00:00:00

  • Techniques of posterior C1-C2 stabilization.

    abstract::Instability of the atlantoaxial complex may result from inflammatory, traumatic, congenital, neoplastic, or degenerative disorders and often requires surgical stabilization. Initial dorsal wiring techniques allow safe fixation but require rigid external immobilization and have been associated with high fusion failure ...

    journal_title:Neurosurgery

    pub_type: 杂志文章,评审

    doi:10.1227/01.NEU.0000249220.50085.E4

    authors: Menendez JA,Wright NM

    更新日期:2007-01-01 00:00:00

  • Regulation of hexokinase in cultured gliomas.

    abstract::Positron emission computed tomographic (PECT) scanning studies have demonstrated that high grade gliomas exhibit increased 2-[18F]fluoro-2-deoxyglucose (18FDG) uptake compared to cerebral white matter and low grade gliomas. Hexokinase catalyzes the phosphorylation of glucose, as well as 18FDG and 2-deoxyglucose (2DG),...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198510000-00001

    authors: Graham JF,Cummins CJ,Smith BH,Kornblith PL

    更新日期:1985-10-01 00:00:00

  • Effects of aortic occlusion on regional spinal cord blood flow and somatosensory evoked potentials in sheep.

    abstract::Somatosensory evoked potentials (SEPs) were recorded continuously during aortic occlusion in sheep, with simultaneous measurement of spinal cord blood flow (SCBF) by radiolabeled microspheres. Aortic occlusion was associated with disappearance of the SEPs in seven of nine sheep in 7.8 +/- 4.1 (SD) minutes. SCBF at the...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/00006123-198711000-00012

    authors: Kaplan BJ,Friedman WA,Gravenstein N,Richards R,Davis RF

    更新日期:1987-11-01 00:00:00

  • The use of susceptibility-weighted imaging as an indicator of retrograde leptomeningeal venous drainage and venous congestion with dural arteriovenous fistula: diagnosis and follow-up after treatment.

    abstract:BACKGROUND:Retrograde leptomeningeal venous drainage (RLVD) in dural arteriovenous fistulas (DAVFs) is associated with intracerebral hemorrhage and nonhemorrhagic neurological deficits or death. Angiographic evidence of RLVD is a definite indication for treatment, but less invasive methods of identifying RLVD are requi...

    journal_title:Neurosurgery

    pub_type: 杂志文章

    doi:10.1227/NEU.0b013e318276f7cc

    authors: Nakagawa I,Taoka T,Wada T,Nakagawa H,Sakamoto M,Kichikawa K,Hironaka Y,Motoyama Y,Park YS,Nakase H

    更新日期:2013-01-01 00:00:00