Abstract:
:Mutual correction of co-cultivated fibroblasts from patients with Hunter's and Hurler's syndrome could be inhibited by either fructose 1-phosphate or mannose 6-phosphate. In the presence of fructose 1-phosphate a 50% mixture of fibroblasts from a patient with Hunter's syndrome and a normal homozygous individual showed an increased 35S-sulphate incorporation into acid mucopolysaccharides. When fibroblast cultures from one obligate and two possible carriers of Hunter's syndrome were tested for 35S-sulphate incorporation, the cultures showed either twice the normal 35S-sulphate incorporation into acid mucopolysaccharides in the presence of fructose 1-phosphate or an abnormally high incorporation in the presence as well as in the absence of the sugar phosphate.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Tønnesen T,Lykkelund C,Güttler Fdoi
10.1007/BF00569706subject
Has Abstractpub_date
1982-01-01 00:00:00pages
167-71issue
2eissn
0340-6717issn
1432-1203journal_volume
60pub_type
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