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Detection of beta-thalassemia and hemoglobin E genes in Thai by a DNA amplification technique.

Abstract：

:Enzymatic DNA amplification and polyacrylamide gel electrophoresis, which demonstrate different sizes of DNA fragments, were used to detect the common mutations causing beta-thalassemia and hemoglobin (Hb) E in Thai people. The 4-bp deletion at codons 41 and 42 can be detected directly by polyacrylamide gel electrophoresis and ethidium bromide staining. Whereas the nonsense mutations at codon 17 (AAG----TAG) and Hb E (GAG----AAG at codon 26) were detected after digestion of the amplified DNA with the enzymes MaeI and MnlI, respectively.

journal_name

Hum Genet

journal_title

Human genetics

authors

Winichagoon P,Kownkon J,Yenchitsomanus P,Thonglairoam V,Siritanaratkul N,Fucharoen S

doi

10.1007/BF00274004

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

389-90

issue

4

eissn

0340-6717

issn

1432-1203

journal_volume

82

pub_type

杂志文章

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