Abstract:
:Hybrids were performed between cell lines derived from four patients with Fanconi's anemia in which different biochemical lesions have been postulated. Complementation studies in these hybrids based on the rate of mitomycin C-induced chromosomal damage supported the concept of allelic mutations. It was therefore concluded that intergenic heterogeneity plays a much lower role in Fanconi's anemia than in Xeroderma pigmentosum or Ataxia teleangiectasia, two other disorders with defective DNA repair.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Zakrzewski S,Koch M,Sperling Kdoi
10.1007/BF00289479subject
Has Abstractpub_date
1983-01-01 00:00:00pages
55-7issue
1eissn
0340-6717issn
1432-1203journal_volume
64pub_type
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