Abstract：
:Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography. Three compounds were fair to very potent competitive antagonists of substance P on three bioassays, i.e., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea. [Arg6,D-Trp10]SP(6-11) is a reasonable antagonist in all three bioassays and [D-Pro4,D-Trp7,9]SP(4-11) is a very potent competitive antagonist with pA2 values ranging around 6.0.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Caranikas S,Mizrahi J,Escher E,Regoli Ddoi
10.1021/jm00353a008subject
Has Abstractpub_date
1982-11-01 00:00:00pages
1313-6issue
11eissn
0022-2623issn
1520-4804journal_volume
25pub_type
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