Radiosynthesis of sigma receptor ligands for positron emission tomography: 11C- and 18F-labeled guanidines.

Abstract:

:A series of analogues of the potent and selective sigma receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the sigma receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue. Three of these 1-aryl-3-(1-adamantyl)guanidines were radiolabeled--two with carbon-11 and one with fluorine-18. Radiochemical yields and specific activities were sufficient for these radiotracers to be used in positron emission tomography imaging of the haloperidol-sensitive sigma receptor.

journal_name

J Med Chem

authors

Wilson AA,Dannals RF,Ravert HT,Sonders MS,Weber E,Wagner HN Jr

doi

10.1021/jm00110a017

keywords:

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

1867-70

issue

6

eissn

0022-2623

issn

1520-4804

journal_volume

34

pub_type

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