Abstract:
:A series of analogues of the potent and selective sigma receptor ligand 1,3-ditolylguanidine (DTG) were synthesized and demonstrated to have high affinity for the sigma receptor as measured by in vitro [3H]DTG displacement studies using guinea pig brain tissue. Three of these 1-aryl-3-(1-adamantyl)guanidines were radiolabeled--two with carbon-11 and one with fluorine-18. Radiochemical yields and specific activities were sufficient for these radiotracers to be used in positron emission tomography imaging of the haloperidol-sensitive sigma receptor.
journal_name
J Med Chemjournal_title
Journal of medicinal chemistryauthors
Wilson AA,Dannals RF,Ravert HT,Sonders MS,Weber E,Wagner HN Jrdoi
10.1021/jm00110a017keywords:
subject
Has Abstractpub_date
1991-06-01 00:00:00pages
1867-70issue
6eissn
0022-2623issn
1520-4804journal_volume
34pub_type
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