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Analgesics. 3. Selected 1-substituted and 1,3-disubstituted 5-propionoxy-5-(1-phenylethyl)barbituric acids.

Abstract：

:Several 1,3-disubstituted and 1-substituted derivatives of 5-propionoxy-5-(1-phenylethyl)barbituric acid were synthesized and evaluated for analgesic activity. Three of these compounds, 1,3-bis(methoxymethyl)-5-propionoxy-5-(1-phenylethyl)barbituric acid (2), 1,3-dimethyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (7), and 1-methyl-5-propionoxy-5-(1-phenylethyl)barbituric acid (10), exhibited better oral activity than codeine sulfate.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Vida JA,Samour CM,O'Dea MH,Reinhard JF

doi

10.1021/jm00241a010

keywords:

subject

Has Abstract

pub_date

1975-07-01 00:00:00

pages

694-6

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

18

pub_type

杂志文章

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