Ahmad-Strong synthesis of 8-, 9-, and 10-pentadecynoic acids.

abstract：:Lipoproteins internalized by the LDL receptor (LDLR) are released from this receptor in endosomes through a process that involves acid-dependent conformational changes in the receptor ectodomain. How acidic pH promotes this release process is not well understood. Here, we assessed roles for six histidine residues for ...

journal_title：Journal of lipid research

authors： Dong H,Zhao Z,LeBrun DG,Michaely P

更新日期：2017-02-01 00:00:00

abstract：:Since the discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) as an attractive target in the treatment of hypercholesterolemia, multiple anti-PCSK9 therapeutic modalities have been pursued in drug development. The objective of this research is to set the stage for the quantitative benchmarking of two an...

journal_title：Journal of lipid research

authors： Sokolov V,Helmlinger G,Nilsson C,Zhudenkov K,Skrtic S,Hamrén B,Peskov K,Hurt-Camejo E,Jansson-Löfmark R

更新日期：2019-09-01 00:00:00

abstract：:We have developed a procedure to quantify apolipoprotein (apo) B-100, apoB-48, and apoE in human triglyceride-rich lipoproteins. This procedure permits delipidation of small amounts of triglyceride-rich lipoproteins without appreciable losses, and quantification of these apolipoproteins in samples containing as little...

journal_title：Journal of lipid research

authors： Kotite L,Bergeron N,Havel RJ

更新日期：1995-04-01 00:00:00

abstract：:The acute-phase response (APR) leads to alterations in lipid metabolism and type II nuclear hormone receptors, which regulate lipid metabolism, are suppressed, in liver, heart, and kidney. Here, we examine the effect of the APR in adipose tissue. In mice, lipopolysaccharide produces a rapid, marked decrease in mRNA le...

journal_title：Journal of lipid research

authors： Lu B,Moser AH,Shigenaga JK,Feingold KR,Grunfeld C

更新日期：2006-10-01 00:00:00

abstract：:Sequence homology indicates the existence of three human cytosolic acyl protein thioesterases, including APT1 that is known to depalmitoylate H- and N-Ras. One of them is the lysophospholipase-like 1 (LYPLAL1) protein that on the one hand is predicted to be closely related to APT1 but on the other hand might also func...

journal_title：Journal of lipid research

authors： Bürger M,Zimmermann TJ,Kondoh Y,Stege P,Watanabe N,Osada H,Waldmann H,Vetter IR

更新日期：2012-01-01 00:00:00

abstract：:The characteristics of 7 alpha-dehydroxylase, a bile acid-biotransforming enzyme, were determined using dialyzed cell extracts of Eubacterium sp. V.P.I. 12708. 7 alpha-Dehydroxylase was induced by cholic acid in this organism. Induction by cholic acid resulted in the differential synthesis of at least five new polypep...

journal_title：Journal of lipid research

authors： White BA,Cacciapuoti AF,Fricke RJ,Whitehead TR,Mosbach EH,Hylemon PB

更新日期：1981-08-01 00:00:00

abstract：:The extent of oxidoreduction of the 3 alpha-, 7 alpha- and 12 alpha-hydroxyl groups in bile acids during the enterohepatic circulation in man was studied with the use of [3 beta-3H]-labeled deoxycholic acid and cholic acid, [7 beta-3H]-labeled cholic acid, and [12 beta-3H]-labeled deoxycholic acid and cholic acid. Eac...

journal_title：Journal of lipid research

authors： Björkhem I,Liljeqvist L,Nilsell K,Einarsson K

更新日期：1986-02-01 00:00:00

abstract：:Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) FAs. Mutations in...

journal_title：Journal of lipid research

authors： Logan S,Agbaga MP,Chan MD,Brush RS,Anderson RE

更新日期：2014-04-01 00:00:00

abstract：:The amphipathic alpha helix is an often-encountered secondary structural motif in biologically active peptides and proteins. An amphipathic helix is defined as an alpha helix with opposing polar and nonpolar faces oriented along the long axis of the helix. In a recent review article we grouped amphipathic helixes into...

journal_title：Journal of lipid research

authors： Jones MK,Anantharamaiah GM,Segrest JP

更新日期：1992-02-01 00:00:00

abstract：:This study sought to clarify the contributions of organic anion-transporting polypeptide (OATP) 1B1 and 1B3 to the liver uptake of chenodeoxycholic acid (CDCA). We synthesized a fluorescent version of CDCA, chenodeoxychilyl-(Nepsilon-NBD)-lysine (CDCA-NBD), to characterize transporter-mediated uptake. CDCA-NBD is effi...

journal_title：Journal of lipid research

authors： Yamaguchi H,Okada M,Akitaya S,Ohara H,Mikkaichi T,Ishikawa H,Sato M,Matsuura M,Saga T,Unno M,Abe T,Mano N,Hishinuma T,Goto J

更新日期：2006-06-01 00:00:00

abstract：:Scavenger receptor class B type I (SR-BI) and ABCA1 are structurally dissimilar cell surface proteins that play key roles in HDL metabolism. SR-BI is a receptor that binds HDL with high affinity and mediates both the selective lipid uptake of cholesteryl esters from lipid-rich HDL to cells and the efflux of unesterifi...

journal_title：Journal of lipid research

authors： Nieland TJ,Chroni A,Fitzgerald ML,Maliga Z,Zannis VI,Kirchhausen T,Krieger M

更新日期：2004-07-01 00:00:00

abstract：:Each abdominal fat depot, such as mesenteric or epididymal, differently contributes to the development of insulin resistance. The aim of this study was to identify the genetic regions that contribute to fat accumulation in epididymal/mesenteric fat and to examine whether or not the genetic regions that affect glucose ...

journal_title：Journal of lipid research

authors： Kobayashi M,Ohno T,Hada N,Fujiyoshi M,Kuga M,Nishimura M,Murai A,Horio F

更新日期：2010-12-01 00:00:00

abstract：:The activity of phospholipase A on phosphatidyl choline and phosphatidal choline spread as monolayers on phosphate buffers containing snake venom (Crotalus atrox or Naja naja) was studied by measuring the fall of surface potential as a function of time, pH, film pressure, temperature, and concentrations of phosphate a...

journal_title：Journal of lipid research

authors： Colacicco G,Rapport MM

更新日期：1966-03-01 00:00:00

abstract：:A report on the effects of primary bile acid ingestion alone or in combination with plant sterols on serum cholesterol levels, biliary lipid secretion, and bile acid metabolism. Biliary bile acid and cholesterol secretion were measured in four patients with type IIa hypercholesterolemia before and after randomized tre...

journal_title：Journal of lipid research

authors： Tangedahl TN,Hofmann AF,Kottke BA

更新日期：1979-01-01 00:00:00

abstract：:Ricinoleic acid (12-hydroxyoctadec-cis-9-enoic acid) has many specialized uses in bioproduct industries, while castor bean is currently the only commercial source for the fatty acid. This report describes metabolic engineering of a microbial system (Pichia pastoris) to produce ricinoleic acid using a "push" (synthesis...

journal_title：Journal of lipid research

authors： Meesapyodsuk D,Chen Y,Ng SH,Chen J,Qiu X

更新日期：2015-11-01 00:00:00

abstract：:Distinct isoforms of long-chain acyl-CoA synthetases (ACSLs) may partition fatty acids toward specific metabolic cellular pathways. For each of the five members of the rat ACSL family, we analyzed tissue mRNA distributions, and we correlated the mRNA, protein, and activity of ACSL1 and ACSL4 after fasting and refeedin...

journal_title：Journal of lipid research

authors： Mashek DG,Li LO,Coleman RA

更新日期：2006-09-01 00:00:00

abstract：:In hepatocytes, vitamin E is secreted via the efflux pathway and is believed to associate with apolipoprotein B (apoB)-lipoproteins extracellularly. The molecular mechanisms involved in the uptake, intracellular trafficking, and secretion of dietary vitamin E by the intestinal cells are unknown. We observed that low c...

journal_title：Journal of lipid research

authors： Anwar K,Kayden HJ,Hussain MM

更新日期：2006-06-01 00:00:00

abstract：:Acylglycerophosphate acyltransferase 4 (AGPAT4)/lysophosphatidic acid acyltransferase delta catalyzes the formation of phosphatidic acid (PA), a precursor of triacyl-glycerol (TAG). We investigated the effect of Agpat4 gene ablation on white adipose tissue (WAT) after finding consistent expression across depots. Epidi...

journal_title：Journal of lipid research

authors： Mardian EB,Bradley RM,Aristizabal Henao JJ,Marvyn PM,Moes KA,Bombardier E,Tupling AR,Stark KD,Duncan RE

更新日期：2017-10-01 00:00:00

abstract：:Four distinct subspecies of the insect hemolymph lipoprotein, lipophorin, that range in diacylglycerol (DAG) content from approximately 100 to 1000 molecules per particle, were treated with phospholipase C. Lipid analysis demonstrated that both phosphatidylcholine and phosphatidylethanolamine were hydrolyzed to DAG. P...

journal_title：Journal of lipid research

authors： Singh TK,Liu H,Bradley R,Scraba DG,Ryan RO

更新日期：1994-09-01 00:00:00

abstract：:Lipid droplet (LD) coating proteins are essential for the formation and stability of intracellular LDs. Plin2 is an abundant LD coating protein in skeletal muscle, but its importance for muscle function is unclear. We show that myotubes established from Plin2-/- mice contain reduced content of LDs and accumulate less ...

journal_title：Journal of lipid research

authors： Feng YZ,Lund J,Li Y,Knabenes IK,Bakke SS,Kase ET,Lee YK,Kimmel AR,Thoresen GH,Rustan AC,Dalen KT

更新日期：2017-11-01 00:00:00

abstract：:The human apolipoprotein C-II locus exhibits genetically determined structural polymorphism in United States and African blacks. In the present study, we have investigated the effect of the apoC-II polymorphism on quantitative serum levels of total cholesterol, total high density lipoprotein (HDL) cholesterol, cholest...

journal_title：Journal of lipid research

authors： Sepehrnia B,Kamboh MI,Adams-Campbell LL,Bunker CH,Nwankwo M,Majumder PP,Ferrell RE

更新日期：1989-09-01 00:00:00

abstract：:A novel metabolite of d-delta-tocopherol was isolated from the urine of rats given d-3,4-[3H2]-delta-tocopherol intravenously. The metabolite was collected from the urine of rats given d-delta-tocopherol in the same manner as that of the labeled compound. It was found that the metabolites consisted of sulfate conjugat...

journal_title：Journal of lipid research

authors： Chiku S,Hamamura K,Nakamura T

更新日期：1984-01-01 00:00:00

abstract：:Autosomal recessive polycystic kidney disease (ARPKD) is a severe, monogenetically inherited kidney and liver disease. PCK rats carrying the orthologous mutant gene serve as a model of human disease, and alterations in lipid profiles in PCK rats suggest that defined subsets of lipids may be useful as molecular disease...

journal_title：Journal of lipid research

authors： Ruh H,Salonikios T,Fuchser J,Schwartz M,Sticht C,Hochheim C,Wirnitzer B,Gretz N,Hopf C

更新日期：2013-10-01 00:00:00

abstract：:Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated with [1-14C]15-hydroxyeicosatetraenoic acid (15-HETE), a lipid mediator of inflammation, and [1-14C]arachidonic acid. Both fatty acids were taken up readily and metabolized by Caco-2 cells. [1-14C]Arachidonic acid was directly esterified in cellu...

journal_title：Journal of lipid research

authors： Riehl TE,Bass NM,Stenson WF

更新日期：1990-05-01 00:00:00

abstract：:In vitro, -polylysine (EPL) strongly inhibited the hydrolysis of trioleoylglycerol emulsified with phosphatidylcholine (PC) and taurocholate by either pancreatic lipase or carboxylester lipase. The EPL concentration required for 50% inhibition of pancreatic lipase, 0.12 microM, was eight times lower than the concentra...

journal_title：Journal of lipid research

authors： Tsujita T,Takaichi H,Takaku T,Aoyama S,Hiraki J

更新日期：2006-08-01 00:00:00

abstract：:Conditions leading to oxidation of LDL in vivo are still unknown. While the occurrence of oxidized lipoproteins and catalytic free iron in advanced atherosclerotic lesions has been demonstrated, the origin of both is unclear. In vivo, iron metabolism is tightly regulated by iron-binding proteins that ensure that virtu...

journal_title：Journal of lipid research

authors： Balagopalakrishna C,Paka L,Pillarisetti S,Goldberg IJ

更新日期：1999-07-01 00:00:00

abstract：:H-Rev107 is a protein that was previously cloned as a negative regulator of proto-oncogene Ras and classified as a class II tumor suppressor. Its structural similarity to lecithin retinol acyltransferase and Ca2+-independent phosphatidylethanolamine (PE) N-acyltransferase led us to analyze H-Rev107 as an enzyme involv...

journal_title：Journal of lipid research

authors： Uyama T,Morishita J,Jin XH,Okamoto Y,Tsuboi K,Ueda N

更新日期：2009-04-01 00:00:00

abstract：:Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo)B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within the ovary, as well as in corresponding plasma samples (n = 12). HDL ch...

journal_title：Journal of lipid research

authors： Gautier T,Becker S,Drouineaud V,Ménétrier F,Sagot P,Nofer JR,von Otte S,Lagrost L,Masson D,Tietge UJ

更新日期：2010-08-01 00:00:00

abstract：:Most mammalian neoplasms have a defect in ether lipid content manifested by the presence of abnormally large quantities of 0-alkyl glyceryl ethers, in contrast to normal tissues in which the alk-1-enyl structure predominates. These lipids are for the most part structural. The manner in which tumor cell plasma membrane...

journal_title：Journal of lipid research

authors： Friedberg SJ,Halpert M

更新日期：1978-01-01 00:00:00

abstract：:Lipids are used as cellular building blocks and condensed energy stores and also act as signaling molecules. The glycerolipid/ fatty acid cycle, encompassing lipolysis and lipogenesis, generates many lipid signals. Reliable procedures are not available for measuring activities of several lipolytic enzymes for the purp...

journal_title：Journal of lipid research

authors： Iglesias J,Lamontagne J,Erb H,Gezzar S,Zhao S,Joly E,Truong VL,Skorey K,Crane S,Madiraju SR,Prentki M

更新日期：2016-01-01 00:00:00