Studies of trans-3-methyl-2-hexenoic acid in normal and schizophrenic humans.

abstract：:Rhizobium chitolipooligosaccharides (CLOSs) are heterogeneous fatty acylated N-acetyl glucosamine oligomers with variations in both the polar (hydrophilic) oligosaccharide head group and the non-polar (hydrophobic) fatty acyl chain. They trigger root hair deformation and cortical cell divisions in legume roots during ...

journal_title：Journal of lipid research

authors： Philip-Hollingsworth S,Dazzo FB,Hollingsworth RI

更新日期：1997-06-01 00:00:00

abstract：:When grown in the presence of bile acids, two strains of Clostridium limosum were found to contain significant amounts of NADP-dependent 7 alpha/7 beta-hydroxysteroid dehydrogenase and NAD-dependent 7 alpha-hydroxysteroid dehydrogenase which were active against conjugated and unconjugated bile acids. No measurable act...

journal_title：Journal of lipid research

authors： Sutherland JD,Williams CN

更新日期：1985-03-01 00:00:00

abstract：:Humans and mice lacking angiopoietin-like protein 3 (ANGPTL3) have pan-hypolipidemia. ANGPTL3 inhibits two intravascular lipases, LPL and endothelial lipase, and the low plasma TG and HDL-cholesterol levels in ANGPTL3 deficiency reflect increased activity of these enzymes. The mechanism responsible for the low LDL-cho...

journal_title：Journal of lipid research

authors： Wang Y,Gusarova V,Banfi S,Gromada J,Cohen JC,Hobbs HH

更新日期：2015-07-01 00:00:00

abstract：:The aim of this study was first to examine the relationships between adiponectin gene (Apm1) polymorphisms and anthropometric indices as well as plasma adiponectin and lipoprotein/lipid levels, and then to investigate whether the presence of visceral obesity or insulin resistance may modulate the impact of these polym...

journal_title：Journal of lipid research

authors： Berthier MT,Houde A,Côté M,Paradis AM,Mauriège P,Bergeron J,Gaudet D,Després JP,Vohl MC

更新日期：2005-02-01 00:00:00

abstract：:Biliary cholesterol secretion is ordinarily tightly coupled to phosphatidylcholine (PC) secretion. Bile PCs are distinct in composition and predominantly composed of molecular species with 16:0 in the sn-1 position and 18:2 and 18:1 in the sn-2 position. In an attempt to acutely change the composition of biliary PCs a...

journal_title：Journal of lipid research

authors： Robins SJ,Fasulo JM,Robins VF,Patton GM

更新日期：1991-06-01 00:00:00

abstract：:Glycosyl hydrolases (GHs) are carbohydrate-active enzymes that hydrolyze a specific β-glycosidic bond in glycoconjugate substrates; β-glucosidases degrade glucosylceramide, a ubiquitous glycosphingolipid. GHs are grouped into structurally similar families that themselves can be grouped into clans. GH1, GH5, and GH30 g...

journal_title：Journal of lipid research

authors： Ben Bdira F,Artola M,Overkleeft HS,Ubbink M,Aerts JMFG

更新日期：2018-12-01 00:00:00

abstract：:The esterification of lysophospholipids contributes to phospholipid synthesis, remodeling, and scavenging. Acyl-CoA-dependent lysophospholipid acyltransferase activity with broad substrate use is mediated by Saccharomyces cerevisiae Lpt1p. We sought to identify Lpt1p active site amino acids besides the histidine conse...

journal_title：Journal of lipid research

authors： Renauer P,Nasiri N,Oelkers P

更新日期：2015-11-01 00:00:00

abstract：:Hepatic lipase (HL) is a lipolytic enzyme, synthesized by hepatocytes and found localized at the surface of liver sinusoid capillaries. In humans, the enzyme is mostly bound onto heparan-sulfate proteoglycans at the surface of hepatocytes and also of sinusoid endothelial cells. HL shares a number of functional domains...

journal_title：Journal of lipid research

authors： Perret B,Mabile L,Martinez L,Tercé F,Barbaras R,Collet X

更新日期：2002-08-01 00:00:00

abstract：:Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides. The mouse expresses three well-...

journal_title：Journal of lipid research

authors： Kim HJ,Miyazaki M,Ntambi JM

更新日期：2002-10-01 00:00:00

abstract：:A qualitative iodometric test for lipoxygenase activity is described. The sensitive method is useful for rapidly screening large numbers of samples, as from a chromatography column or after enzyme inactivation treatment in food processing. ...

journal_title：Journal of lipid research

authors： Wallace JM

更新日期：1972-03-01 00:00:00

abstract：:The effects of intravenous injection of lipopolysaccharide (LPS) and tumor necrosis factor alpha (TNF) were investigated in cynomolgus monkeys (Macaca fascicularis). Injection of 20 micrograms/kg of LPS from E. coli (serotype 055:B5) into cynomolgus monkeys fed a monkey chow diet caused a twofold increase in plasma tr...

journal_title：Journal of lipid research

authors： Ettinger WH,Miller LD,Albers JJ,Smith TK,Parks JS

更新日期：1990-06-01 00:00:00

abstract：:Human lysosomal acid lipase/cholesteryl ester hydrolase (hLAL) is essential for the intralysosomal metabolism of cholesteryl esters and triglycerides taken up by receptor-mediated endocytosis of lipoprotein particles. The key role of the enzyme in intracellular lipid homeostasis is illustrated by two lysosomal storage...

journal_title：Journal of lipid research

authors： Lohse P,Maas S,Sewell AC,van Diggelen OP,Seidel D

更新日期：1999-02-01 00:00:00

abstract：:Here, we present an improved method for sensitive profiling of lipids in a single high-performance liquid chromatography-electrospray ionization-quadrupole time of flight mass spectrometry experiment. The approach consists of i) sensitive isocratic elution, which takes advantage of C18 column material that is resistan...

journal_title：Journal of lipid research

authors： Shui G,Bendt AK,Pethe K,Dick T,Wenk MR

更新日期：2007-09-01 00:00:00

abstract：:We have studied the rate of phospholipid synthesis and turnover in mouse peritoneal macrophages in reaction to cholesterol influx and high density lipoprotein (HDL)-mediated cholesterol efflux, using three different radioactive precursors, 32PO4(3-), [3H]choline, and [14C]oleic acid. The cells were loaded with cholest...

journal_title：Journal of lipid research

authors： Schmitz G,Beuck M,Fischer H,Nowicka G,Robenek H

更新日期：1990-10-01 00:00:00

abstract：:Adiponectin, an adipocyte-derived protein, has anti-atherogenic and anti-diabetic effects, but how it confers the anti-atherogenic effects is not well understood. To study the anti-atherogenic mechanisms of adiponectin, we examined whether it interacts with atherogenic low-density lipoprotein (LDL) to attenuate LDL's ...

journal_title：Journal of lipid research

authors： Kakino A,Fujita Y,Ke LY,Chan HC,Tsai MH,Dai CY,Chen CH,Sawamura T

更新日期：2020-11-03 00:00:00

abstract：:Lipid concentrations are heritable traits. Recently, the number of known genetic loci associated with lipid levels in adults increased from 95 to 157. The effects of these 157 loci have not been tested in children. Considering that lipid levels track from childhood to adulthood, we studied to determine whether these v...

journal_title：Journal of lipid research

authors： Latsuzbaia A,Jaddoe VW,Hofman A,Franco OH,Felix JF

更新日期：2016-12-01 00:00:00

abstract：:Lipid droplet proteins (LDPs) coat the surface of triglyceride-rich lipid droplets and regulate their formation and lipolysis. We profiled hepatic LDP expression in fatty liver dystrophic (fld) mice, a unique model of neonatal hepatic steatosis that predictably resolves between postnatal day 14 (P14) and P17. Western ...

journal_title：Journal of lipid research

authors： Hall AM,Brunt EM,Chen Z,Viswakarma N,Reddy JK,Wolins NE,Finck BN

更新日期：2010-03-01 00:00:00

abstract：:Chronic inflammation contributes to cardiovascular disease. Increased levels of the inflammatory cytokine, TNF-α, are often present in conditions associated with cardiovascular disease risk, and TNF-α induces a number of pro-atherogenic effects in macrovascular endothelial cells, including expression of adhesion molec...

journal_title：Journal of lipid research

authors： Jung HS,Shimizu-Albergine M,Shen X,Kramer F,Shao D,Vivekanandan-Giri A,Pennathur S,Tian R,Kanter JE,Bornfeldt KE

更新日期：2020-01-01 00:00:00

abstract：:Autotaxin (ATX), which is highly expressed and secreted by adipocytes, functions as the key enzyme to generate lysophosphatidic acid (LPA) from lysophosphatidylcholine. Adipose tissue is the main source of circulating ATX that modulates plasma LPA levels. Upregulation of ATX expression in obese patients and mice is cl...

journal_title：Journal of lipid research

authors： Sun S,Wang R,Song J,Guan M,Li N,Zhang X,Zhao Z,Zhang J

更新日期：2017-11-01 00:00:00

abstract：:Semi-purified diets supplemented with either a high linoleate (n-6) (safflower) oil or a high alpha-linolenate (n-3) (perilla) oil were fed to mouse mothers and their offspring through 6 weeks of age. The proportions of n-3 and n-6 highly unsaturated fatty acids in brain phospholipids reflected the n-3/n-6 balance of ...

journal_title：Journal of lipid research

authors： Nakashima Y,Yuasa S,Hukamizu Y,Okuyama H,Ohhara T,Kameyama T,Nabeshima T

更新日期：1993-02-01 00:00:00

abstract：:Polyunsaturated fatty acids, including docosahexaenoic acid (DHA, 22:6n-3), modulate immune responses and exert beneficial immunosuppressive effects, but the molecular mechanisms inhibiting T-cell activation are not yet elucidated. Lipid rafts have been shown to play an important role in the compartmentalization and m...

journal_title：Journal of lipid research

authors： Li Q,Wang M,Tan L,Wang C,Ma J,Li N,Li Y,Xu G,Li J

更新日期：2005-09-01 00:00:00

abstract：:We analyzed Niemann-Pick type C disease 1 (NPC1) gene in 12 patients with Niemann-Pick type C disease by sequencing both cDNA obtained from fibroblasts and genomic DNA. All the patients were compound heterozygotes. We found 15 mutations, eight of which previously unreported. The comparison of cDNA and genomic DNA reve...

journal_title：Journal of lipid research

authors： Tarugi P,Ballarini G,Bembi B,Battisti C,Palmeri S,Panzani F,Di Leo E,Martini C,Federico A,Calandra S

更新日期：2002-11-01 00:00:00

abstract：:Leukotrienes (LTs) play major roles in lung immune responses, and LTD4 is the most potent agonist for cysteinyl LT1, leading to bronchoconstriction and tissue remodeling. Here, we studied LT crosstalk between myeloid cells and pulmonary epithelial cells. Monocytic cells (Mono Mac 6 cell line, primary dendritic cells) ...

journal_title：Journal of lipid research

authors： Lukic A,Ji J,Idborg H,Samuelsson B,Palmberg L,Gabrielsson S,Rådmark O

更新日期：2016-09-01 00:00:00

abstract：:Remnant-like emulsions were prepared with lipid compositions similar to remnants derived from triacylglycerol-rich lipoproteins. When injected into the bloodstream of conscious mice the remnant-like emulsions labeled with cholesteryl[13C]oleate were metabolized in the liver and the appearance of 13CO2 in the breath wa...

journal_title：Journal of lipid research

authors： Martins IJ,Redgrave TG

更新日期：1998-03-01 00:00:00

abstract：:In an effort to explore the feasibility of converting a lipase into an esterase by modifying the lid region, we designed and characterized two novel Rhizopus chinensis lipase variants by lid swapping. The substrate specificity of an R. chinensis lipase was successfully modified toward water-soluble substrates, that is...

journal_title：Journal of lipid research

authors： Yu XW,Zhu SS,Xiao R,Xu Y

更新日期：2014-06-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:Recent studies from our laboratory (Yancey, P.G., and R. W. St. Clair. 1992. Arterioscler. Thromb. 12: 1291-1304) have shown that cultured peritoneal macrophages from White Carneau (WC) pigeons clear cholesteryl esters at a slower rate than do macrophages from Show Racer (SR) pigeons (9% per 24 h vs. 42% per 24 h, res...

journal_title：Journal of lipid research

authors： Yancey PG,St Clair RW

更新日期：1994-12-01 00:00:00

abstract：:Purified liver plasma membranes were prepared from rats fed a high-fat, carbohydrate-free diet or a high-glucose, fat-free diet. Membranes from rats fed the high-fat diet bound significantly less 125I-labeled concanavalin A (Con A) than did those from rats fed the fat-free diets. The magnitude of the binding differenc...

journal_title：Journal of lipid research

authors： Henriquez DS,Tepperman HM,Tepperman J

更新日期：1979-07-01 00:00:00

abstract：:Diet-induced changes in high density lipoprotein (HDL) density and size were studied in patas monkeys. When the animals were switched from a moderate fat-low cholesterol diet to a high fat-high cholesterol (HFHC) diet, the plasma apoA-I levels increased initially in all of the animals. The apoA-I levels remained eleva...

journal_title：Journal of lipid research

authors： Melchior GW,Baker HN,Abee CR,Roheim PS

更新日期：1984-09-01 00:00:00

abstract：:Conditions under which apolipoprotein (apo) A-I dissociates from human high density lipoproteins (HDL) during incubation in vitro have been investigated. Dissociation of apoA-I was demonstrated by non-denaturing gradient gel electrophoresis followed by immunoblotting for apoA-I and by size-exclusion chromatography. It...

journal_title：Journal of lipid research

authors： Liang HQ,Rye KA,Barter PJ

更新日期：1994-07-01 00:00:00