Resolution of a spectrum of nucleoprotein species in sonicated chromatin.

abstract：:The binding of chylomicron remnants rat liver plasma membranes was studied. Liver membranes bound up to 8 times more remnants than they bound chylomicrons. The remnant particle appeared to bind to the membrane as a unit. Remnant binding was greatest to liver plasma membrane; only one third as much binding was observed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrella M,Cooper AD

更新日期：1979-01-01 00:00:00

abstract：:Cellular imbalance in the levels of antioxidants and reactive oxygen species resulting in apoptosis is directly associated with a number of parasitic infections, aging, and several genetic and multifactorial diseases. The baculovirus AcNPV-encoded antiapoptotic p35 gene prevents apoptosis induced by a variety of apopt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sah NK,Taneja TK,Pathak N,Begum R,Athar M,Hasnain SE

更新日期：1999-04-27 00:00:00

abstract：:We study the dynamic network of e-mail traffic and find that it develops self-organized coherent structures similar to those appearing in many nonlinear dynamic systems. Such structures are uncovered by a general information theoretic approach to dynamic networks based on the analysis of synchronization among trios of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eckmann JP,Moses E,Sergi D

更新日期：2004-10-05 00:00:00

abstract：:Species competing exclusively for renewing resources are shown to obey simultaneous differential equations equivalent to the conditions for minimizing a certain quadratic form. In this sense competition acts to select species abundances giving the best least-squares fit in an expression [Formula: see text] Thus the nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arthur RM

更新日期：1969-12-01 00:00:00

abstract：:Most studies of cytoskeletal organelles have concentrated on molecular analyses of abundant and biochemically accessible structures. In many of the classical cases, however, the nature of the system chosen has precluded a concurrent genetic analysis. The mitotic spindle of the yeast Saccharomyces cerevisiae is one exa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillus L,Solomon F

更新日期：1986-04-01 00:00:00

abstract：:Myosin V, a double-headed molecular motor, transports organelles within cells by walking processively along actin, a process that requires coordination between the heads. To understand the mechanism underlying this coordination, processive runs of single myosin V molecules were perturbed by varying nucleotide content....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baker JE,Krementsova EB,Kennedy GG,Armstrong A,Trybus KM,Warshaw DM

更新日期：2004-04-13 00:00:00

abstract：:IDIOTYPY HAS BEEN STUDIED IN ANTIBODIES AGAINST A PROTEIN ANTIGEN: hen ovalbumin. Various fractions of antisera to hen ovalbumin have been compared from the standpoint of the idiotypic specificities found on the immunoglobulins that they contain. Idiotypic specificities were found to be common to (a) antibodies that w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oudin J,Cazenave PA

更新日期：1971-10-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs selective for inhibition of COX-2 increase heart failure and elevate blood pressure. The COX-2 gene was floxed and crossed into merCremer mice under the alpha-myosin heavy-chain promoter. Tamoxifen induced selective deletion of COX-2 in cardiomyocytes depressed cardiac output, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Patel VV,Ricciotti E,Zhou R,Levin MD,Gao E,Yu Z,Ferrari VA,Lu MM,Xu J,Zhang H,Hui Y,Cheng Y,Petrenko N,Yu Y,FitzGerald GA

更新日期：2009-05-05 00:00:00

abstract：:Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation. The transcriptional on-off cycle is linked to the segmentation clock. In our current study, we show that a T-box transcripti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yasuhiko Y,Haraguchi S,Kitajima S,Takahashi Y,Kanno J,Saga Y

更新日期：2006-03-07 00:00:00

abstract：:By exploiting the ability of Pseudomonas aeruginosa to infect a variety of vertebrate and nonvertebrate hosts, we have developed model systems that use plants and nematodes as adjuncts to mammalian models to help elucidate the molecular basis of P. aeruginosa pathogenesis. Our studies reveal a remarkable degree of con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahme LG,Ausubel FM,Cao H,Drenkard E,Goumnerov BC,Lau GW,Mahajan-Miklos S,Plotnikova J,Tan MW,Tsongalis J,Walendziewicz CL,Tompkins RG

更新日期：2000-08-01 00:00:00

abstract：:Biological processes such as circadian rhythms, cell division, metabolism, and development occur as ordered sequences of events. The synchronization of these coordinated events is essential for proper cell function, and hence the determination of critical time points in biological processes is an important component o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan N,Tadepalli S,Watson LT,Helm RF,Antoniotti M,Mishra B

更新日期：2010-07-13 00:00:00

abstract：:Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein. Insertions between these elements have two effects: the site of cleavage moves in concert with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharl EC,Steitz JA

更新日期：1996-12-10 00:00:00

abstract：:Exposure of adipocytes to antibodies to the insulin receptor results in a blockade of (125)I-labeled insulin binding, stimulation of glucose oxidation, and many more insulin-like effects. Allowing for differences in purity, antireceptor antibody is equipotent with insulin on a molar basis. Both the bivalent F(ab')(2) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kahn CR,Baird KL,Jarrett DB,Flier JS

更新日期：1978-09-01 00:00:00

abstract：:We recently developed the electron force field (eFF) method for practical nonadiabatic electron dynamics simulations of materials under extreme conditions and showed that it gave an excellent description of the shock thermodynamics of hydrogen from molecules to atoms to plasma, as well as the electron dynamics of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim H,Su JT,Goddard WA 3rd

更新日期：2011-09-13 00:00:00

abstract：:A complex between soluble dextran and human hemoglobin has been synthesized by two different methods. In the alkylation method, hemoglobin was allowed to react with bromoacetyl groups incorporated into the dextran; the yield of the complex was about 80% in terms of the hemoglobin used. In the dialdehyde method, hemogl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tam SC,Blumenstein J,Wong JT

更新日期：1976-06-01 00:00:00

abstract：:Forkhead box class O (FoxO) transcription factors are key regulators of growth, metabolism, life span, and stress resistance. FoxOs integrate signals from different pathways and guide the cellular response to varying energy and stress conditions. FoxOs are modulated by several signaling pathways, e.g., the insulin-TOR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mattila J,Kallijärvi J,Puig O

更新日期：2008-09-30 00:00:00

abstract：:Go is a specific class ("other") of signal-transducing heterotrimeric GTP-binding proteins (G proteins) that is expressed in high levels in mammalian brain. We have cloned two different rat cDNAs encoding the alpha subunit of Go (Go alpha-1 and Go alpha-2) and a human Go alpha chromosomal gene. The human Go alpha gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsukamoto T,Toyama R,Itoh H,Kozasa T,Matsuoka M,Kaziro Y

更新日期：1991-04-15 00:00:00

abstract：:Antisense oligodeoxyribonucleotides targeted to the epidermal growth factor (EGF) receptor were encapsulated into liposomes linked to folate via a polyethylene glycol spacer (folate-PEG-liposomes) and efficiently delivered into cultured KB cells via folate receptor-mediated endocytosis. The oligonucleotides were a pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Lee RJ,Cauchon G,Gorenstein DG,Low PS

更新日期：1995-04-11 00:00:00

abstract：:Human infections with Ebola virus (EBOV) result in a deadly viral disease known as Ebola hemorrhagic fever. Up to 90% of infected patients die, and there is no available treatment or vaccine. The sporadic human outbreaks are believed to result when EBOV "jumps" from an infected animal to a person and is subsequently t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strong JE,Wong G,Jones SE,Grolla A,Theriault S,Kobinger GP,Feldmann H

更新日期：2008-11-18 00:00:00

abstract：:Measurements of submicron particles by Fourier transform infrared spectroscopy in 14 campaigns in North America, Asia, South America, and Europe were used to identify characteristic organic functional group compositions of fuel combustion, terrestrial vegetation, and ocean bubble bursting sources, each of which often ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russell LM,Bahadur R,Ziemann PJ

更新日期：2011-03-01 00:00:00

abstract：:The role of the renin-angiotensin system in blood pressure control and in the development of hypertension was investigated by generating transgenic mice carrying the rat renin or angiotensinogen gene or both genes under the control of the mouse metallothionein I promoter. The systolic blood pressure was significantly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohkubo H,Kawakami H,Kakehi Y,Takumi T,Arai H,Yokota Y,Iwai M,Tanabe Y,Masu M,Hata J

更新日期：1990-07-01 00:00:00

abstract：:A typing method for bacteria was developed and applied to several species, including Escherichia coli and Actinobacillus actinomycetemcomitans. Total genomic DNA was digested with a restriction endonuclease, and fragments were enabled with [alpha-32P]dATP by using the Klenow fragment of DNA polymerase and separated by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Steenbergen TJ,Colloms SD,Hermans PW,de Graaff J,Plasterk RH

更新日期：1995-06-06 00:00:00

abstract：:During oxygenic photosynthesis in cyanobacteria and chloroplasts of plants and eukaryotic algae, conversion of light energy to biologically useful chemical energy occurs in the specialized thylakoid membranes. Light-induced charge separation at the reaction centers of photosystems I and II, two multisubunit pigment-pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zak E,Norling B,Maitra R,Huang F,Andersson B,Pakrasi HB

更新日期：2001-11-06 00:00:00

abstract：:Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawson WE,Cheng DS,Degryse AL,Tanjore H,Polosukhin VV,Xu XC,Newcomb DC,Jones BR,Roldan J,Lane KB,Morrisey EE,Beers MF,Yull FE,Blackwell TS

更新日期：2011-06-28 00:00:00

abstract：:The method of evolutionary stable strategies (ESS), in its current form, is confronted with a difficulty when it tries to explain how some social behaviors initiate their evolution. We show that this difficulty may be removed by changing the assumption made tacitly in game theory (and in ESS) of randomness of meetings...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eshel I,Cavalli-Sforza LL

更新日期：1982-02-01 00:00:00

abstract：:The pyridoxal phosphate-dependent enzyme, 1-aminocyclopropane-1-carboxylate synthase (ACS; EC 4.4.1.14), catalyzes the rate-limiting step in the ethylene biosynthetic pathway in plants. The Arabidopsis genome encodes nine ACS polypeptides that form eight functional (ACS2, ACS4-9, ACS11) and one nonfunctional (ACS1) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsuchisaka A,Theologis A

更新日期：2004-02-24 00:00:00

abstract：:Cell membrane contact induces the de novo expression of choline O-acetyltransferase (CAT; acetyl-CoA: choline O-acetyltransferase, EC 2.3.1.6) activity in cultures of virtually pure neonatal rat dissociated sympathetic neurons. To identify molecular mechanisms underlying membrane-associated CAT induction, the responsi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adler JE,Schleifer LS,Black IB

更新日期：1989-02-01 00:00:00

abstract：:Pathways and enzymes of fatty acid synthase-mediated, long-even-chain (generally C16-C20) fatty acid synthesis are well studied, and general metabolism involved in short-chain (C4-C7) fatty acid biosynthesis is also understood. In contrast, mechanisms of medium-chain (C8-C14) fatty acid synthesis are unclear. Recent w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroumova AB,Xie Z,Wagner GJ

更新日期：1994-11-22 00:00:00

abstract：:We have constructed 26-amino acid transmembrane proteins that specifically transform cells but consist of only two different amino acids. Most proteins are long polymers of amino acids with 20 or more chemically distinct side-chains. The artificial transmembrane proteins reported here are the simplest known proteins w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heim EN,Marston JL,Federman RS,Edwards AP,Karabadzhak AG,Petti LM,Engelman DM,DiMaio D

更新日期：2015-08-25 00:00:00

abstract：:Estimates of 21st Century global-mean surface temperature increase have generally been based on scenarios that do not include climate policies. Newly developed multigas mitigation scenarios, based on a wide range of modeling approaches and socioeconomic assumptions, now allow the assessment of possible impacts of clim...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Vuuren DP,Meinshausen M,Plattner GK,Joos F,Strassmann KM,Smith SJ,Wigley TM,Raper SC,Riahi K,de la Chesnaye F,den Elzen MG,Fujino J,Jiang K,Nakicenovic N,Paltsev S,Reilly JM

更新日期：2008-10-07 00:00:00