Abstract:
:The biodistribution of 131I-6 beta-iodomethyl-19-norcholesterol (NP-59) was assessed in hypercholesterolaemic patients and in a rabbit model of HC to examine the alterations in the relative distribution of NP-59 and its metabolites and to explain the changes in the patterns of adrenal cortical imaging in patients with expanded cholesterol pools. Rabbits were rendered hypercholesterolaemic with a diet supplemented with 2% cholesterol for 2 weeks prior to the intravenous administration of 240 to 570 microCi of NP-59. Adrenal, bile and serum samples were obtained from four hypercholesterolaemic rabbits at 48 h following NP-59 administration, and the distribution of 131I radioactivity was compared to that of seven rabbits maintained on a standard laboratory diet. Serum cholesterol levels were 1940 +/- 248 mg dl-1 in the hypercholesterolaemic rabbits as compared to 268 +/- 62 mg dl-1 in the controls. Adrenal cortical uptake of NP-59 was decreased in HC rabbits but no significant differences were observed in the relative proportions of NP-59 or its metabolites in the bile and adrenal tissues of hypercholesterolaemic versus control animals. Hypercholesterolaemic animals did exhibit an increase in NP-59 esters in serum as compared to controls. In three of five patients with hypercholesterolaemia, adrenal uptake of NP-59 was enhanced after successful lowering of serum cholesterol levels, while the remaining two patients who responded inadequately to cholesterol-lowering therapy showed a slight drop in NP-59 uptake.
journal_name
Nucl Med Communjournal_title
Nuclear medicine communicationsauthors
Lynn MD,Gross MD,Shapiro B,Bassett Ddoi
10.1097/00006231-198608000-00010subject
Has Abstractpub_date
1986-08-01 00:00:00pages
631-7issue
8eissn
0143-3636issn
1473-5628journal_volume
7pub_type
杂志文章abstract::A significant reduction of cardiac 123I-meta-iodobenzylguanidine (MIBG) accumulation has been reported in patients with idiopathic Parkinson's disease. However, it is unclear whether this reduction in cardiac sympathetic nerve is caused primarily or secondarily to the degeneration of sympathetic nerve centres which oc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-200202000-00008
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:Single photon emission tomography (SPECT) of the lung is a well-established non-invasive technique for quantitative assessment of regional lung ventilation and perfusion distribution in children and in adults. However, its application in neonates as well as infants has been scarce because of several practica...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f25905
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:In this study, primary tumors' fluorine-18-fluorodeoxyglucose (F-FDG) uptake in luminal A, luminal B, triple-negative, and human epidermal growth factor receptor type-2 subtypes of breast cancer was evaluated. In addition, the relationship between the primary tumor maximum standardized uptake value (SUVmax) v...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000856
更新日期:2018-07-01 00:00:00
abstract::Measurements were made of the concentration of radioactivity in the breast milk of two patients: one following 100 MBq (2.7 mCi) 99Tcm-pertechnetate administration, and the other following administration of 550 MBq (15 mCi) 99Tcm-glucoheptonate. The fractional activity concentrations in the former case were about two ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-198710000-00011
更新日期:1987-10-01 00:00:00
abstract::The efficacy of wipe tests for assessing 99Tcm surface contamination was measured. Four types of surface were contaminated with four radiopharmaceuticals and wiped using four types of swab. The fraction of activity removed was measured by direct monitoring for each combination of surface, pharmaceutical and swab. The ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199102000-00005
更新日期:1991-02-01 00:00:00
abstract:PURPOSE:Despite the growing use of fluorine-18-fluorodeoxyglucose (F-FDG) PET texture analysis to measure intratumoural heterogeneity in cancer research, the biologic basis of F-FDG PET-derived texture variables is poorly understood. We aimed to assess correlations between F-FDG PET-derived texture variables and whole-...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0000000000000925
更新日期:2018-12-01 00:00:00
abstract::A miniature, non-imaging caesium iodide nuclear probe optically coupled to a photodiode (the 'Cardioscint') has been developed which, in conjunction with a modified personal computer, is capable of continuous on-line monitoring of left ventricular function and ST-segment level at the bedside. The purpose of this study...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199205000-00004
更新日期:1992-05-01 00:00:00
abstract::A comparative study of bone marrow scintigraphy using 99Tcm-nanocolloid, conventional bone scintigraphy and bone marrow biopsy were performed in 35 patients with histologically proven small cell carcinoma of the lung to determine whether bone marrow scintigraphy has a role in the early detection of bone marrow metasta...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199401000-00006
更新日期:1994-01-01 00:00:00
abstract::Technetium-99m-galactosyl human serum albumin (99mTc-GSA) is a radiopharmaceutical that binds to asialoglycoprotein receptors in the hepatocyte membrane; the level of 99mTc-GSA accumulation in the liver correlates well with the parameters of hepatic function tests. We hypothesized that the early blood kinetics of 99mT...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200107000-00008
更新日期:2001-07-01 00:00:00
abstract::Findings of hepatobiliary scintigraphy with intravenous cholecystokinin octapeptide (sincalide) were examined in 26 asymptomatic patients with various malignancies but no known pre-existing gallbladder disease, and normal hepatobiliary and gallbladder morphology on sonography. The maximum gallbladder ejection fraction...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199606000-00010
更新日期:1996-06-01 00:00:00
abstract::Salivary gland scintigraphy (SGS) is used to depict salivary gland dysfunction after radiotherapy (RT). The aim of this study was to investigate the utility of SGS combined with single photon emission computed tomography (SPECT). Twenty-one patients with a carcinoma of head and neck underwent SGS before and 1 month af...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-200102000-00015
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Interobserver agreement in measuring positron emission tomography (PET)/computed tomography (CT) parameters is critical for head and neck cancer management. The purpose of this study is to assess the interobserver agreement when measuring the standardized uptake value (SUV) parameters and the diameter of pri...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834e5397
更新日期:2012-03-01 00:00:00
abstract::We studied 20 patients aged 46-69 years (mean 57 years) undergoing long-term haemodialysis (HD) and 20 age- and sex-matched controls with single photon emission tomography (SPET) and 99Tcm-hexamethyl-propyleneamine-oxime to look for regional abnormalities in cerebral blood flow (CBF) and their relation to cognitive dy...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199607000-00011
更新日期:1996-07-01 00:00:00
abstract::Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showe...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199905000-00008
更新日期:1999-05-01 00:00:00
abstract::Radiolabeled sucralfate has been utilized by several investigators to evaluate peptic ulcer, active inflammatory bowel disease, esophageal ulcer, and gastric cancer. A review of the available literature indicates that radiolabeled sucralfate has been used to evaluate peptic ulcer and active inflammatory bowel diseases...
journal_title:Nuclear medicine communications
pub_type: 杂志文章,评审
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Gated blood-pool single-photon emission computed tomography (GBPS) was compared with cardiac magnetic resonance (CMR) for the measurement of left ventricular (LV) and right ventricular (RV) ejection fractions (EF) and volumes [end-diastolic volume (EDV) or end-systolic volume (ESV)] in a mixed population. ME...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/MNM.0b013e32834155f1
更新日期:2011-02-01 00:00:00
abstract:AIM:The first pathogenetic step in multiple myeloma is the emergence of a limited number of clonal plasma cells, clinically known as monoclonal gammopathy of undetermined significance (MGUS). Patients with MGUS do not have symptoms or end-organ damage but they do have a 1% annual risk of progression to multiple myeloma...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3282f5e5df
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVES:Single-photon emission computed tomography ventilation/perfusion (SPECT V/Q) imaging is recommended both by the Society of Nuclear Medicine and by the European Association of Nuclear Medicine for the diagnosis of pulmonary embolism. However, respiratory motion produces image blurring and degradation of detai...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000015
更新日期:2014-02-01 00:00:00
abstract::Cystic fibrosis patients require pancreatic enzyme supplements to aid food digestion. It is suspected that incorrect delivery of this enzyme may result in both significant malabsorption and the development of strictures in the proximal colon caused by the high-dose supplement reaching this region before the food. Inve...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199808000-00006
更新日期:1998-08-01 00:00:00
abstract::This paper proposes the utilization of 225Ac for the alpha-radioimmunotherapy of cancer. The isotope decays with a radioactive half-life of 10 days into a cascade of short-lived alpha- and beta-emitting isotopes. In addition, when indicated by the pharmacokinetic requirements of particular clinical applications, 213Bi...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199302000-00009
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Clinical studies in women using technetium-99m (Tc)-Bombesin have shown successful radionuclide imaging of breast tumours overexpressing gastrin-releasing peptide receptors (GRPRs). Recent studies have demonstrated that most breast tumours overexpress folate receptors (FRα). AIM:The aim of this work was to ...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000460
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:Detection of recurrent disease is essential for treatment planning in patients with paraganglioma. The aim of this study was to compare 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy [whole-body and single-photon emission computed tomography (SPECT) computed tomography (CT) scanning] and fluorine-18-L...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e328345a340
更新日期:2011-07-01 00:00:00
abstract::Heart uptake and clearance of 123I-15-(p-iodophenyl)-3(R,S)-methyl- pentadecanoic acid (BMIPP) by whole-body scintigraphy in relation to left ventricular ejection fraction (LVEF) was evaluated in 34 patients with ischaemic heart disease. At 45 and 210 min after injection, anterior whole-body images were obtained. In e...
journal_title:Nuclear medicine communications
pub_type: 临床试验,杂志文章
doi:10.1097/00006231-199409000-00004
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:Human serum albumin (HSA), which has 58 Lys residues, one Cys residue, and indocyanine green (ICG) adsorption sites, can be used as a multifunctional platform for the development of hybrid imaging probes. In this study, we prepared 64Cu-labeled mannose-conjugated HSA with and without ICG ([64Cu]1-ICG and [64C...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000353
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Determine the prevalence of benign indium-111 (In) pentetreotide uptake in the pancreatic head and determine if a semi-quantitative method can be used to differentiate physiologic from pathologic uptake. PATIENTS AND METHODS:Institutional Review Board-approved, HIPAA-compliant retrospective review of 197 som...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001022
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to compare quantitative ECG-gated single-photon emission computed tomography (SPECT) (QGS) and model-based ECG-gated single-photon emission computed tomography (MBGS) for determination of end-diastolic cardiac volume (EDV), end-systolic cardiac volume (ESV), and left ventricular...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e3283294d19
更新日期:2009-04-01 00:00:00
abstract:PURPOSES:This study aims to explore the prognostic value of left ventricular mechanical dyssynchrony (LVMD) in hypertrophic cardiomyopathy (HCM) patients with low risk of sudden cardiac death (SCD). METHODS:This retrospective study was performed in 50 patients with HCM who underwent Tc-99m sestamibi GSPECT-MPI. All pa...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000001322
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:We retrospectively investigated the value of dynamic Tc-diisopropyl-iminodiacetic acid hepatobiliary scintigraphy (HBS) in discriminating postsurgical complications following liver transplantation (LT). METHODS:Dynamic HBS was performed for suspected post-LT complications in 201 cases. Hepatic uptake and exc...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0b013e32834fc5e6
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Trastuzumab (T) and anthracycline (A)-based chemotherapy is considered the standard of care in human epidermal growth factor receptor-2+ overexpressing breast cancer, but requires monitoring for known cardiotoxicity using left ventricular (LV) ejection fraction (EF) every 3-4 months during treatment. It is n...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/MNM.0000000000000941
更新日期:2019-01-01 00:00:00
abstract::The application of a Well-type germanium semiconductor detector creates new possibilities in erythrocyte survival studies. Using 51Cr, the effective dose equivalent in a standard procedure can be reduced from approximately 780 to 2 microSv. The properties of the detector, namely, high efficiency and high energy resolu...
journal_title:Nuclear medicine communications
pub_type: 杂志文章
doi:10.1097/00006231-199105000-00010
更新日期:1991-05-01 00:00:00