Abstract:
:Many cancers and other chronic diseases are associated with a long delay between exposure to a putative risk factor and subsequent diagnosis. This presents well recognised problems in the elucidation of suspected risk factors by epidemiological methods. In this paper we discuss the interpretation in epidemiological studies of the effect of a possible risk factor when population exposure is recent and rapidly changing. An important contemporary example concerns the study of early oral contraceptive (OC) use in relation to the subsequent risk of breast cancer. Computer simulations reported here indicate that plausible delays in the manifestation of any effect on breast cancer incidence make it difficult to exclude early OC use as a risk factor for breast cancer, even when large well conducted epidemiological studies show no apparent increased risk. Methods for detecting a 'latent' effect are discussed.
journal_name
J Epidemiol Community Healthjournal_title
Journal of epidemiology and community healthauthors
McPherson K,Coope PA,Vessey MPdoi
10.1136/jech.40.4.289subject
Has Abstractpub_date
1986-12-01 00:00:00pages
289-94issue
4eissn
0143-005Xissn
1470-2738journal_volume
40pub_type
杂志文章abstract:BACKGROUND:There are few longitudinal studies investigating the risk of major depression by socioeconomic status (SES). In this study, data from the longitudinal cohort of Canadian National Population Health Survey were used to estimate the risk of major depressive episode (MDE) over 6 years by SES levels. METHODS:The...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2009.090910
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Antiretroviral therapy (ART) initiation is now recommended irrespective of CD4 count. However data on the relationship between CD4 count at ART initiation and loss to follow-up (LTFU) are limited and conflicting. METHODS:We conducted a cohort analysis including all adults initiating ART (2008-2012) at three...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,多中心研究
doi:10.1136/jech-2015-206629
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Metabolic syndrome (MS) has an increased risk for developing cardiovascular disease (CVD); however, whether the concept of MS, applying the new joint interim statement definition, has a greater impact on incident CVD than its individual components is debated. METHODS:The authors related MS and its component...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.117697
更新日期:2012-05-01 00:00:00
abstract::This analysis attempts to fill the gap in the epidemiological evidence about the relation between dietary salt and hypertension. Changes in the purchase of salt in England and Wales are compared with changes in mortality from cerebrovascular disease (1958-78). Stroke mortality, a major sequel of hypertension, has decl...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.37.1.25
更新日期:1983-03-01 00:00:00
abstract::An exponential model based on the infectious disease model of Kermack and McKendrick has been simplified to illustrate how the use of heroin spreads in epidemic fashion. A numerical simulation is arranged to show how the dynamics of spread are influenced by the original number of users, rates of conversion, and time o...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.33.4.299
更新日期:1979-12-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate age, period, and cohort effects on functional status. DESIGN:A prospective cohort study with measurements in 1981, 1990, and 1996. SETTING:Three municipalities in north east Finland. PARTICIPANTS:A regionally representative sample of 19 to 63 year old men and women was drawn from the c...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.56.12.905
更新日期:2002-12-01 00:00:00
abstract:STUDY OBJECTIVE:This study examined the change in ethnic differences in mortality in Estonia 1989-2000. DESIGN:Two unlinked cross sectional census based analyses were compared. Total and cause specific mortality was analysed for ethnic Estonians and Russians. The absolute differences in mortality were evaluated throug...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2003.013755
更新日期:2004-07-01 00:00:00
abstract:BACKGROUND:Data from primary care records could potentially provide more comprehensive population-level information on smoking prevalence at lower cost and in a more timely fashion than commissioned national surveys. Therefore, we compared smoking prevalence calculated from a database of primary care electronic medical...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2010.120154
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To evaluate whether coronary artery bypass graft (CABG) surgery is equally provided among different socioeconomic status (SES) groups in accordance with need. To estimate the association between SES and mortality occurring 30 days after CABG surgery. DESIGN:Individual socioeconomic index assigned with respe...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/jech.54.12.930
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:An association between socioeconomic status (SES) and the incidence of type 2 diabetes mellitus (T2DM) has been found for younger and middle-aged individuals, but studies of this relationship in elderly populations are rare. METHODS:In a population-based cohort in southern Germany (KORA S4/F4: 1223 subjects...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2009.094086
更新日期:2011-07-01 00:00:00
abstract::Delay in the presentation of symptoms and in referral of patients for surgical opinion remains an important problem in colorectal cancer. Factors influencing patients to consult early include advice from close family or other associates and abdominal pain or vomiting, or both, as one of the early symptoms. More locali...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.38.2.122
更新日期:1984-06-01 00:00:00
abstract::A recent study by Knox concludes that cases and "clusters" of two or more cases of childhood leukaemia and non-Hodgkin's lymphoma occur closer to many kinds of industrial installation than to supposedly comparable control locations. It is argued that these findings could be largely or entirely artefactual, the apparen...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.49.4.437
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Inverse associations between perceived control and cardiovascular disease (CVD) have been reported in studies from Western Europe and the USA. To assess this relationship across different populations, we investigated the association between perceived control and all-cause and CVD mortality in three populatio...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2017-208992
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Although pregnancy is a time when women have increased motivation to quit smoking, approximately half of female smokers persist in smoking throughout their pregnancies. Persistent pregnancy smokers are known to be more nicotine dependent and to have greater sociodemographic disadvantage. Less is known about ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.082594
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:The authors assessed whether socioeconomic inequalities in asthma symptoms were already present in preschool children and to what extent prenatal, perinatal and postnatal risk factors for asthma symptoms mediate the effect of socioeconomic status (SES). METHODS:The study included 3136 Dutch children partici...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2011-200333
更新日期:2012-11-01 00:00:00
abstract:STUDY OBJECTIVE:Micronutrient deficiencies have become rare in industrialised countries as availability of fresh food, supplementation, and fortification have improved but a less favourable situation may still prevail in many developing countries. Blood thiamin status and determinants were therefore investigated in the...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.52.4.237
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:To assess the effect of the Demerit Point System (DPS), introduced in Spain on 1 July 2006, on the number of fatalities due to road traffic accidents, using a methodology that controls for the seasonal variation and trend in the data series. METHODS:Time-series analysis by ARIMA models of 29 113 fatalities ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2008.082461
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The Great East Japan Earthquake and subsequent tsunami and nuclear disaster on 11 March 2011 had a short-term influence on the increase in emergency department visits and hospital admissions due to various diseases. However, it remains unclear whether the earthquake and tsunami disaster affected the long-ter...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2016-207413
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:High intelligence early in life has consistently been associated with decreased mortality, but the mechanisms are still not fully understood. In this cohort study, we examined the association between intelligence in early adulthood and later mortality from natural and unnatural causes taking birth weight, pa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2013-202637
更新日期:2014-02-01 00:00:00
abstract::This is the report of a feasibility study of a randomised controlled trial of chiropractic and hospital outpatient management for low back pain of mechanical origin. Preparations for the study included an approach to the General Medical Council for guidance about the intended collaboration between medically qualified ...
journal_title:Journal of epidemiology and community health
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/jech.40.1.12
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the short term effect of air pollution on cardiovascular admissions in 14 Spanish cities METHODS:The period under study was from 1995 to 1999. Daily emergency admissions for all cardiovascular diseases (CVD) and heart diseases (HD) were obtained from hospital records, and the corresponding daily ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,多中心研究
doi:10.1136/jech.2005.037978
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:The aim was to study whether women having had caesarean sections (index women) have more subsequent health problems, measured by hospital admissions, than women having had vaginal deliveries (control women). DESIGN:The study involved comparison of hospital admissions before (2-5 years) and after (7-10 years)...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.45.1.24
更新日期:1991-03-01 00:00:00
abstract:STUDY OBJECTIVE:To estimate the incidence of occupational asthma seen by respiratory and occupational physicians in the UK in 1989 and 1990. DESIGN:New cases of occupational asthma were taken from a national reporting scheme, the Surveillance of Work-related and Occupational Respiratory Disease Project (SWORD). Estima...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.47.6.459
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:There is concern about the health of populations living close to nuclear waste reprocessing plants. A comparative study was conducted on reproductive life events in the general population living near the nuclear waste reprocessing plant in Beaumont-Hague, France and a reference area in Brittany. DESIGN, SETT...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2007.061069
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The effect of modifying lifestyle at middle age on mortality has been sparsely examined. METHODS:Men and women aged 50-54 years randomised to the control group (no intervention) in the population-based Norwegian Colorectal Cancer Prevention trial were asked to fill in lifestyle questionnaires in 2001 and 20...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,随机对照试验
doi:10.1136/jech-2015-206760
更新日期:2017-01-01 00:00:00
abstract::Socioeconomic differentials in the uptake of medical care in men were investigated using data from the General Household Survey (1974-76 and 1979-80). Hospitalisation, attendance at out patient clinics, and consultation with doctors were higher in local authority tenants than in owner occupiers. Men belonging to the m...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.41.3.196
更新日期:1987-09-01 00:00:00
abstract:BACKGROUND:The evidence on mortality patterns by education in Spain comes from regional areas. This study aimed to estimate these patterns in the whole Spanish population. METHODS:All citizens aged 25 years and over and residing in Spain in 2001 were followed during 7 years to determine their vital status, resulting i...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech-2014-204186
更新日期:2014-12-01 00:00:00
abstract::The effect of moderate to heavy exposure to alcohol and tobacco on the risk of cancer of the hypopharynx is estimated in a case-control study. All incident hypopharyngeal cancer patients in Denmark who were under 75 years of age were compared with incident cases of laryngeal cancer and population sampled controls. The...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.39.4.304
更新日期:1985-12-01 00:00:00
abstract:INTRODUCTION:Manitoba's The Need to Know project was presented with a unique opportunity to develop a collaborative approach to evaluation, and to explore the effectiveness of a variety of evaluation methods for assessment of university-community collaborative health research partnerships. OBJECTIVES:The evaluation wa...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章
doi:10.1136/jech.2005.040881
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:To assess evidence for residential mobility in childhood having an adverse association with health outcomes through the life course. METHODS:A systematic search of medical and social sciences literature was undertaken to identify research defining residential mobility as an independent variable and in which ...
journal_title:Journal of epidemiology and community health
pub_type: 杂志文章,评审
doi:10.1136/jech.2007.060103
更新日期:2008-07-01 00:00:00