Abstract:
:Confined chorionic mosaicism, detected commonly on chorionic villus sampling (CVS) and occasionally in cultured amniotic fluid cells, is described in five pregnancies that showed confined chorionic mosaicism for trisomies 12, 13, 14, 17 and a marker chromosome. Cytogenetic findings in these pregnancies support the conclusion that within chorion some chromosomal mosaicism are confined to the trophectoderm derivatives while others to the extra-embryonic mesoderm. The etiology of confined chorionic mosaicism is discussed in relation to a significant role of multiple cell lineages contributing to the early development of placenta. The need is indicated for the use of both direct and long-term cultures in CVS prenatal diagnosis, and for the confirmatory testing of fetal blood or amniotic fluid in cases where mosaicism is detected in chorionic villi.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Kalousek DK,Dill FJ,Pantzar T,McGillivray BC,Yong SL,Wilson RDdoi
10.1007/BF00272385subject
Has Abstractpub_date
1987-10-01 00:00:00pages
163-7issue
2eissn
0340-6717issn
1432-1203journal_volume
77pub_type
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