Abstract:
:Hereditary nonpolyposis colorectal cancer (HN-PCC) is one of man's commonest hereditary diseases. Several studies have identified four responsible genes that are involved in a process known as DNA mismatch repair; hMSH2 is the most important of these four genes. In addition to mutational analysis of these genes, investigations of transcriptional regulatory mechanisms are important. Therefore, our purpose has been to isolate the hMSH2 promoter region. Using direct sequencing of P1 recombinant DNA we have characterized 1100 bp of the hMSH2 promoter.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Scherer SJ,Seib T,Seitz G,Dooley S,Welter Cdoi
10.1007/BF00218844subject
Has Abstractpub_date
1996-01-01 00:00:00pages
114-6issue
1eissn
0340-6717issn
1432-1203journal_volume
97pub_type
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