Abstract:
:Amplification of the beta-globin gene by the polymerase chain reaction (PCR) and direct sequencing were used for a fast and reliable identification of the beta-globin variant Hb D Los Angeles and revealed the predicted G----C substitution in codon 121. The same method showed the molecular defect in Hb Presbyterian to be a C----G substitution in codon 108; this eliminates a MaeII restriction site.
journal_name
Hum Genetjournal_title
Human geneticsauthors
Schnee J,Aulehla-Scholz C,Eigel A,Horst Jdoi
10.1007/BF00196236subject
Has Abstractpub_date
1990-03-01 00:00:00pages
365-7issue
4eissn
0340-6717issn
1432-1203journal_volume
84pub_type
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