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Synthesis and antiinflammatory and analgesic activity of 5-aroyl-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acids. The 6-substituted compounds.

Abstract：

:5-Aroyl-6-substituted-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carbo xylic acids were synthesized and assayed for analgesic and antiinflammatory activity. Several of these compounds, notably the 5-(4-fluoro- and 4-chlorobenzoyl)-6-methyl derivatives 25 and 26 and the 5-(4-methyl-, 4-fluoro-, 4-chloro-, and 4-methoxybenzoyl)-6-chloro congeners 31-34 were of equal or greater potency than indomethacin as antiinflammatory and analgesic agents both in acute and chronic animal models.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Muchowski JM,Cooper GF,Halpern O,Koehler R,Kluge AF,Simon RL,Unger SH,Van Horn AR,Wren DL,Ackrell J

doi

10.1021/jm00388a013

subject

Has Abstract,Author List Incomplete

pub_date

1987-05-01 00:00:00

pages

820-3

issue

5

eissn

0022-2623

issn

1520-4804

journal_volume

30

pub_type

杂志文章

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