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Antimycotic azoles. 7. Synthesis and antifungal properties of a series of novel triazol-3-ones.

Abstract：

:A series of novel triazol-3-ones have been synthesized, and their in vitro and in vivo antifungal properties are reported. Compound 68 (itraconazole), which displays a pronounced oral activity against vaginal candidosis in rats and against microsporosis in guinea pigs, has been selected for clinical evaluation.

journal_name

J Med Chem

journal_title

Journal of medicinal chemistry

authors

Heeres J,Backx LJ,Van Cutsem J

doi

10.1021/jm00373a015

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

894-900

issue

7

eissn

0022-2623

issn

1520-4804

journal_volume

27

pub_type

杂志文章

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