Genome-wide identification of the histone acetyltransferase gene family in Triticum aestivum.

abstract：BACKGROUND:MicroRNAs (miRNAs) are short non-coding RNAs that are emerging as important post-transcriptional regulators of neuronal and synaptic development. The precise impact of miRNAs on presynaptic function and neurotransmission remains, however, poorly understood. RESULTS:Here, we identify miR-27b-an abundant neur...

journal_title：BMC genomics

authors： Poon VY,Gu M,Ji F,VanDongen AM,Fivaz M

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:GLV-1h68 is an attenuated recombinant vaccinia virus (VACV) that selectively colonizes established human xenografts inducing their complete regression. RESULTS:Here, we explored xenograft/VACV/host interactions in vivo adopting organism-specific expression arrays and tumor cell/VACV in vitro comparing VACV ...

journal_title：BMC genomics

authors： Worschech A,Chen N,Yu YA,Zhang Q,Pos Z,Weibel S,Raab V,Sabatino M,Monaco A,Liu H,Monsurró V,Buller RM,Stroncek DF,Wang E,Szalay AA,Marincola FM

更新日期：2009-07-07 00:00:00

abstract：:ᅟ: Upon publication of the original article [1], the authors had flagged that there was an error in Fig. 1c, as the key in this figure was displaying incorrectly. The colours had not displayed in the key in the final published article, and instead appear as plain white. ...

journal_title：BMC genomics

authors： Hohmann N,Koch MA

更新日期：2018-04-11 00:00:00

abstract：BACKGROUND:Drug resistance has become a severe challenge for treatment of HIV infections. Mutations accumulate in the HIV genome and make certain drugs ineffective. Prediction of resistance from genotype data is a valuable guide in choice of drugs for effective therapy. RESULTS:In order to improve the computational pr...

journal_title：BMC genomics

authors： Yu X,Weber IT,Harrison RW

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Reliable indicators for the onset of flowering are not available for most perennial monocarpic species, representing a drawback for crops such as bamboo, agave and banana. The ability to predict and control the transition to the reproductive stage in A. tequilana would represent an advantage for field manage...

journal_title：BMC genomics

authors： Avila de Dios E,Delaye L,Simpson J

更新日期：2019-06-10 00:00:00

abstract：BACKGROUND:Gene targeting by homology-directed repair (HDR) can precisely edit the genome and is a versatile tool for biomedical research. However, the efficiency of HDR-based modification is still low in many model organisms including zebrafish. Recently, long single-stranded DNA (lssDNA) molecules have been developed...

journal_title：BMC genomics

authors： Bai H,Liu L,An K,Lu X,Harrison M,Zhao Y,Yan R,Lu Z,Li S,Lin S,Liang F,Qin W

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Bifidobacterial genome analysis has provided insights as to how these gut commensals adapt to and persist in the human GIT, while also revealing genetic diversity among members of a given bifidobacterial (sub)species. Bifidobacteria are notoriously recalcitrant to genetic modification, which prevents explora...

journal_title：BMC genomics

authors： O'Callaghan A,Bottacini F,O'Connell Motherway M,van Sinderen D

更新日期：2015-10-21 00:00:00

abstract：BACKGROUND:Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabol...

journal_title：BMC genomics

authors： Fonknechten N,Chaussonnerie S,Tricot S,Lajus A,Andreesen JR,Perchat N,Pelletier E,Gouyvenoux M,Barbe V,Salanoubat M,Le Paslier D,Weissenbach J,Cohen GN,Kreimeyer A

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:The transition from exponential to stationary phase in Streptomyces coelicolor is accompanied by a major metabolic switch and results in a strong activation of secondary metabolism. Here we have explored the underlying reorganization of the metabolome by combining computational predictions based on constrain...

journal_title：BMC genomics

authors： Alam MT,Merlo ME,STREAM Consortium.,Hodgson DA,Wellington EM,Takano E,Breitling R

更新日期：2010-03-26 00:00:00

abstract：BACKGROUND:Arsenic (As) exposure is a significant worldwide environmental health concern. Low dose, chronic arsenic exposure has been associated with a higher than normal risk of skin, lung, and bladder cancer, as well as cardiovascular disease and diabetes. While arsenic-induced biological changes play a role in disea...

journal_title：BMC genomics

authors： Riedmann C,Ma Y,Melikishvili M,Godfrey SG,Zhang Z,Chen KC,Rouchka EC,Fondufe-Mittendorf YN

更新日期：2015-03-19 00:00:00

abstract：BACKGROUND:Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared the miRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOP protocol 2001. RESULTS:We did not find a significant difference between miRNA signature of both groups...

journal_title：BMC genomics

authors： Schmitt J,Backes C,Nourkami-Tutdibi N,Leidinger P,Deutscher S,Beier M,Gessler M,Graf N,Lenhof HP,Keller A,Meese E

更新日期：2012-08-07 00:00:00

abstract：BACKGROUND:Due to the limited availability and high cost of fish oil in the face of increasing aquaculture production, there is a need to reduce usage of fish oil in aquafeeds without compromising farm fish health. Therefore, the present study was conducted to determine if different levels of vegetable and fish oils ca...

journal_title：BMC genomics

authors： Eslamloo K,Xue X,Hall JR,Smith NC,Caballero-Solares A,Parrish CC,Taylor RG,Rise ML

更新日期：2017-09-08 00:00:00

abstract：BACKGROUND:Nucleosome positioning has an important role in gene regulation. However, dynamic positioning in vivo casts doubt on the reliability of predictions based on DNA sequence characteristics. What role does sequence-dependent positioning play? In this paper, using a curvature profile model, nucleosomes are predic...

journal_title：BMC genomics

authors： Liu H,Duan X,Yu S,Sun X

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Macrosatellites are some of the largest variable number tandem repeats in the human genome, but what role these unusual sequences perform is unknown. Their importance to human health is clearly demonstrated by the 4q35 macrosatellite D4Z4 that is associated with the onset of the muscle degenerative disease f...

journal_title：BMC genomics

authors： Tremblay DC,Alexander G Jr,Moseley S,Chadwick BP

更新日期：2010-11-15 00:00:00

abstract：BACKGROUND:Gene expression profiling studies of mastitis in ruminants have provided key but fragmented knowledge for the understanding of the disease. A systematic combination of different expression profiling studies via meta-analysis techniques has the potential to test the extensibility of conclusions based on singl...

journal_title：BMC genomics

authors： Genini S,Badaoui B,Sclep G,Bishop SC,Waddington D,Pinard van der Laan MH,Klopp C,Cabau C,Seyfert HM,Petzl W,Jensen K,Glass EJ,de Greeff A,Smith HE,Smits MA,Olsaker I,Boman GM,Pisoni G,Moroni P,Castiglioni B,Cremon

更新日期：2011-05-11 00:00:00

abstract：BACKGROUND:Whole transcriptome analyses are an essential tool for understanding disease mechanisms. Approaches based on next-generation sequencing provide fast and affordable data but rely on the availability of annotated genomes. However, there are many areas in biomedical research that require non-standard animal mod...

journal_title：BMC genomics

authors： Schmucki R,Berrera M,Küng E,Lee S,Thasler WE,Grüner S,Ebeling M,Certa U

更新日期：2013-04-10 00:00:00

abstract：BACKGROUND:Analysis of single nucleotide polymorphisms (SNPs) derived from whole-genome studies allows for rapid evaluation of genome-wide diversity, and genomic epidemiology studies of Plasmodium falciparum provide insights into parasite population structure, gene flow, drug resistance and vaccine development. In area...

journal_title：BMC genomics

authors： Jacob CG,Tan JC,Miller BA,Tan A,Takala-Harrison S,Ferdig MT,Plowe CV

更新日期：2014-08-26 00:00:00

abstract：BACKGROUND:After several years in the juvenile phase, trees undergo flowering transition to become mature (florally competent) trees. This transition depends on the balanced expression of a complex network of genes that is regulated by both endogenous and environmental factors. However, relatively little is known about...

journal_title：BMC genomics

authors： Zhang JZ,Ai XY,Sun LM,Zhang DL,Guo WW,Deng XX,Hu CG

更新日期：2011-01-26 00:00:00

abstract：BACKGROUND:Cytoplasmic male sterility (CMS) is an inability to produce functional pollen that is caused by mutation of the mitochondrial genome. Comparative analyses of mitochondrial genomes of lines with and without CMS in several species have revealed structural differences between genomes, including extensive rearra...

journal_title：BMC genomics

authors： Jo YD,Choi Y,Kim DH,Kim BD,Kang BC

更新日期：2014-07-04 00:00:00

abstract：BACKGROUND:Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of human proteins that associate with the nucleolus. However, in most cases, we know neither the fraction...

journal_title：BMC genomics

authors： Scott MS,Boisvert FM,Lamond AI,Barton GJ

更新日期：2011-01-27 00:00:00

abstract：BACKGROUND:Several resistance traits, including the I2 resistance against tomato fusarium wilt, were mapped to the long arm of chromosome 11 of Solanum. However, the structure and evolution of this locus remain poorly understood. RESULTS:Comparative analysis showed that the structure and evolutionary patterns of the I...

journal_title：BMC genomics

authors： Wei C,Kuang H,Li F,Chen J

更新日期：2014-08-30 00:00:00

abstract：BACKGROUND:Transcription factor (TF) GAMYB, belonging to MYB family (named after the gene of the avian myeloblastosis virus) is a master gibberellin (GA)-induced regulatory protein that is crucial for development and germination of cereal grain and involved in anther formation. It activates many genes including high-mo...

journal_title：BMC genomics

authors： Bienias A,Góralska M,Masojć P,Milczarski P,Myśków B

更新日期：2020-08-24 00:00:00

abstract：BACKGROUND:The membrane protein CD46, a ubiquitous cell surface pathogen receptor, can bind Streptococcus to trigger cell autophagy, which is a critical step in the control of infection. RESULTS:In this study, we found a new splice variant designated CD46 transcript variant (CD46-TV). The splice variant is characteriz...

journal_title：BMC genomics

authors： Wang X,Zhong J,Gao Y,Ju Z,Huang J

更新日期：2014-07-28 00:00:00

abstract：BACKGROUND:The human gastric pathogen Helicobacter pylori is a paradigm for chronic bacterial infections. Its persistence in the stomach mucosa is facilitated by several mechanisms of immune evasion and immune modulation, but also by an unusual genetic variability which might account for the capability to adapt to chan...

journal_title：BMC genomics

authors： Fischer W,Breithaupt U,Kern B,Smith SI,Spicher C,Haas R

更新日期：2014-04-27 00:00:00

abstract：BACKGROUND:In the postgenome era, a prediction of response to treatment could lead to better dose selection for patients in radiotherapy. To identify a radiosensitive gene signature and elucidate related signaling pathways, four different microarray experiments were reanalyzed before radiotherapy. RESULTS:Radiosensiti...

journal_title：BMC genomics

authors： Kim HS,Kim SC,Kim SJ,Park CH,Jeung HC,Kim YB,Ahn JB,Chung HC,Rha SY

更新日期：2012-07-30 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is one of the most common forms of cancer associated with the presence of precancerous oral leukoplakia. Given the poor prognosis associated with oral leukoplakia, and the difficulties in distinguishing it from cancer lesions, there is an urgent need to elucidate the molec...

journal_title：BMC genomics

authors： Wang Z,Feng X,Liu X,Jiang L,Zeng X,Ji N,Li J,Li L,Chen Q

更新日期：2009-08-19 00:00:00

abstract：BACKGROUND:Lactose provides an easily-digested energy source for neonates, and is the primary carbohydrate in milk in most species. Bovine lactose is also a key component of many human food products. However, compared to analyses of other milk components, the genetic control of lactose has been little studied. Here we ...

journal_title：BMC genomics

authors： Lopdell TJ,Tiplady K,Struchalin M,Johnson TJJ,Keehan M,Sherlock R,Couldrey C,Davis SR,Snell RG,Spelman RJ,Littlejohn MD

更新日期：2017-12-15 00:00:00

abstract：BACKGROUND:Alpha tubulin is a fundamental component of the cytoskeleton which is responsible for cell shape and is involved in cell division, ciliary and flagellar motility and intracellular transport. Alpha tubulin gene expression varies according to the morphological changes suffered by Leishmania in its life cycle. ...

journal_title：BMC genomics

authors： Ramírez CA,Requena JM,Puerta CJ

更新日期：2013-07-06 00:00:00

abstract：BACKGROUND:Aneuploidies are copy number variants that affect entire chromosomes. They are seen commonly in cancer, embryonic stem cells, human embryos, and in various trisomic diseases. Aneuploidies frequently affect only a subset of cells in a sample; this is known as "mosaic" aneuploidy. A cell that harbours an aneup...

journal_title：BMC genomics

authors： Griffiths JA,Scialdone A,Marioni JC

更新日期：2017-11-25 00:00:00

abstract：BACKGROUND:The molecular mechanisms that determine the organism's response to a variety of doses and modalities of stress factors are not well understood. RESULTS:We studied effects of ionizing radiation (144, 360 and 864 Gy), entomopathogenic fungus (10 and 100 CFU), starvation (16 h), and cold shock (+4, 0 and -4°C)...

journal_title：BMC genomics

authors： Moskalev A,Zhikrivetskaya S,Krasnov G,Shaposhnikov M,Proshkina E,Borisoglebsky D,Danilov A,Peregudova D,Sharapova I,Dobrovolskaya E,Solovev I,Zemskaya N,Shilova L,Snezhkina A,Kudryavtseva A

更新日期：2015-01-01 00:00:00