Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy.

abstract：BACKGROUND:Linkage disequilibrium (LD) plays a fundamental role in population genetics and in the current surge of studies to screen for subtle genetic variants affecting complex traits. Methods widely implemented in LD analyses require samples to be randomly collected, which, however, are usually ignored and thus rais...

journal_title：BMC genomics

authors： Wang M,Jia T,Jiang N,Wang L,Hu X,Luo Z

更新日期：2010-05-26 00:00:00

abstract：BACKGROUND:This paper presents a retrospective statistical study on the newly-released data set by the Stanley Neuropathology Consortium on gene expression in bipolar disorder and schizophrenia. This data set contains gene expression data as well as limited demographic and clinical data for each subject. Previous studi...

journal_title：BMC genomics

authors： Struyf J,Dobrin S,Page D

更新日期：2008-11-07 00:00:00

abstract：BACKGROUND:The genomic architecture of adaptive traits remains poorly understood in non-model plants. Various approaches can be used to bridge this gap, including the mapping of quantitative trait loci (QTL) in pedigrees, and genetic association studies in non-structured populations. Here we present results on the geno...

journal_title：BMC genomics

authors： Prunier J,Pelgas B,Gagnon F,Desponts M,Isabel N,Beaulieu J,Bousquet J

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Non-coding small RNAs play critical roles in various cellular processes in a wide spectrum of eukaryotic organisms. Their responses to abiotic stress have become a popular topic of economic and scientific importance in biological research. Several studies in recent years have reported a small number of non-c...

journal_title：BMC genomics

authors： Wang L,Yu X,Wang H,Lu YZ,de Ruiter M,Prins M,He YK

更新日期：2011-06-03 00:00:00

abstract：BACKGROUND:The small airway epithelium (SAE), the cell population that covers the human airway surface from the 6th generation of airway branching to the alveoli, is the major site of lung disease caused by smoking. The focus of this study is to provide quantitative assessment of the SAE transcriptome in the resting st...

journal_title：BMC genomics

authors： Hackett NR,Butler MW,Shaykhiev R,Salit J,Omberg L,Rodriguez-Flores JL,Mezey JG,Strulovici-Barel Y,Wang G,Didon L,Crystal RG

更新日期：2012-02-29 00:00:00

abstract：:In 2009 the International Society for Computational Biology (ISCB) started to roll out regional bioinformatics conferences in Africa, Latin America and Asia. The open and competitive bid for the first meeting in Asia (ISCB-Asia) was awarded to Asia-Pacific Bioinformatics Network (APBioNet) which has been running the I...

journal_title：BMC genomics

authors： Schönbach C,Tan TW,Kelso J,Rost B,Nathan S,Ranganathan S

更新日期：2011-11-30 00:00:00

abstract：BACKGROUND:Human herpesvirus-6A and -6B (HHV-6) are betaherpesviruses that reach > 90% seroprevalence in the adult population. Unique among human herpesviruses, HHV-6 can integrate into the subtelomeric regions of human chromosomes; when this occurs in germ line cells it causes a condition called inherited chromosomall...

journal_title：BMC genomics

authors： Greninger AL,Knudsen GM,Roychoudhury P,Hanson DJ,Sedlak RH,Xie H,Guan J,Nguyen T,Peddu V,Boeckh M,Huang ML,Cook L,Depledge DP,Zerr DM,Koelle DM,Gantt S,Yoshikawa T,Caserta M,Hill JA,Jerome KR

更新日期：2018-03-20 00:00:00

abstract：BACKGROUND:Second-generation sequencing technologies have revolutionized our ability to recover genetic information from the past, allowing the characterization of the first complete genomes from past individuals and extinct species. Recently, third generation Helicos sequencing platforms, which perform true Single-Mol...

journal_title：BMC genomics

authors： Ginolhac A,Vilstrup J,Stenderup J,Rasmussen M,Stiller M,Shapiro B,Zazula G,Froese D,Steinmann KE,Thompson JF,Al-Rasheid KA,Gilbert TM,Willerslev E,Orlando L

更新日期：2012-05-10 00:00:00

abstract：BACKGROUND:Galileo is one of three members of the P superfamily of DNA transposons. It was originally discovered in Drosophila buzzatii, in which three segregating chromosomal inversions were shown to have been generated by ectopic recombination between Galileo copies. Subsequently, Galileo was identified in six of 12 ...

journal_title：BMC genomics

authors： Gonçalves JW,Valiati VH,Delprat A,Valente VL,Ruiz A

更新日期：2014-09-13 00:00:00

abstract：BACKGROUND:A sense-antisense gene pair (SAGP) is a gene pair where two oppositely transcribed genes share a common nucleotide sequence region. In eukaryotic genomes, SAGPs can be organized in complex sense-antisense architectures (CSAGAs) in which at least one sense gene shares loci with two or more antisense partners....

journal_title：BMC genomics

authors： Grinchuk OV,Motakis E,Kuznetsov VA

更新日期：2010-02-10 00:00:00

abstract：BACKGROUND:Infectious laryngotracheitis virus (ILTV; gallid herpesvirus 1) infection causes high mortality and huge economic losses in the poultry industry. To protect chickens against ILTV infection, chicken-embryo origin (CEO) and tissue-culture origin (TCO) vaccines have been used. However, the transmission of vacci...

journal_title：BMC genomics

authors： Lee J,Bottje WG,Kong BW

更新日期：2012-04-24 00:00:00

abstract：BACKGROUND:Lipoxygenases (LOXs), a type of non-haem iron-containing dioxygenase, are ubiquitous enzymes in plants and participate in the formation of fruit aroma which is a very important aspect of fruit quality. Amongst the various aroma volatiles, saturated and unsaturated alcohols and aldehydes provide the character...

journal_title：BMC genomics

authors： Li M,Li L,Dunwell JM,Qiao X,Liu X,Zhang S

更新日期：2014-06-07 00:00:00

abstract：BACKGROUND:Identification of acute or recent hepatitis C virus (HCV) infections is important for detecting outbreaks and devising timely public health interventions for interruption of transmission. Epidemiological investigations and chemistry-based laboratory tests are 2 main approaches that are available for identifi...

journal_title：BMC genomics

authors： Lara J,Teka M,Khudyakov Y

更新日期：2017-12-06 00:00:00

abstract：BACKGROUND:The molecular mechanisms of transcriptional regulation are poorly understood in Plasmodium falciparum. In addition, most of the genes in Plasmodium falciparum are transcriptionally poised and only a handful of cis-regulatory elements are known to operate in transcriptional regulation. Here, we employed an ep...

journal_title：BMC genomics

authors： Ubhe S,Rawat M,Verma S,Anamika K,Karmodiya K

更新日期：2017-08-23 00:00:00

abstract：BACKGROUND:Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of microarray data is the availability of a reference to compare signal intensities to reliably determine presence or divergence each DNA fragment. Howeve...

journal_title：BMC genomics

authors： Carpaij N,Fluit AC,Lindsay JA,Bonten MJ,Willems RJ

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:In animals, signaling of Bone Morphogenetic Proteins (BMPs) is essential for dorsoventral (DV) patterning of the embryo, but how BMP signaling evolved with changes in embryonic DV differentiation is largely unclear. Based on the extensive knowledge of BMP signaling in Drosophila melanogaster, the morphologic...

journal_title：BMC genomics

authors： Lemke S,Antonopoulos DA,Meyer F,Domanus MH,Schmidt-Ott U

更新日期：2011-05-31 00:00:00

abstract：BACKGROUND:A-to-I RNA-editing mediated by ADAR (adenosine deaminase acting on RNA) enzymes that converts adenosine to inosine in RNA sequence can generate mutations and alter gene regulation in metazoans. Previous studies have shown that A-to-I RNA-editing plays vital roles in mouse embryogenesis. However, the RNA-edit...

journal_title：BMC genomics

authors： Qiu S,Li W,Xiong H,Liu D,Bai Y,Wu K,Zhang X,Yang H,Ma K,Hou Y,Li B

更新日期：2016-09-29 00:00:00

abstract：BACKGROUND:The gut of phloem feeding insects is critical for nutrition uptake and xenobiotics degradation. However, partly due to its tiny size, genomic information for the gut of phloem feeding insects is limited. RESULTS:In this study, the gut transcriptomes of two species of invasive whiteflies in the Bemisia tabac...

journal_title：BMC genomics

authors： Ye XD,Su YL,Zhao QY,Xia WQ,Liu SS,Wang XW

更新日期：2014-05-15 00:00:00

abstract：BACKGROUND:Hypoxia Inducible Factor (HIF) regulates a cascade of transcriptional events in response to decreased oxygenation, acting from the cellular to the physiological level. This response is evolutionarily conserved, allowing the use of zebrafish (Danio rerio) as a model for studying the hypoxic response. Activati...

journal_title：BMC genomics

authors： Greenald D,Jeyakani J,Pelster B,Sealy I,Mathavan S,van Eeden FJ

更新日期：2015-11-11 00:00:00

abstract：BACKGROUND:Gene targeting by homology-directed repair (HDR) can precisely edit the genome and is a versatile tool for biomedical research. However, the efficiency of HDR-based modification is still low in many model organisms including zebrafish. Recently, long single-stranded DNA (lssDNA) molecules have been developed...

journal_title：BMC genomics

authors： Bai H,Liu L,An K,Lu X,Harrison M,Zhao Y,Yan R,Lu Z,Li S,Lin S,Liang F,Qin W

更新日期：2020-01-21 00:00:00

abstract：BACKGROUND:Tubulin isotypes and expression patterns are highly regulated in diverse organisms. The genome sequence of the protozoan parasite Leishmania major contains three distinct beta-tubulin loci. To investigate the diversity of beta-tubulin genes, we have compared the published genome sequence to draft genome sequ...

journal_title：BMC genomics

authors： Jackson AP,Vaughan S,Gull K

更新日期：2006-06-06 00:00:00

abstract：BACKGROUND:With the advance of new massively parallel genotyping technologies, quantitative trait loci (QTL) fine mapping and map-based cloning become more achievable in identifying genes for important and complex traits. Development of high-density genetic markers in the QTL regions of specific mapping populations is ...

journal_title：BMC genomics

authors： Wu X,Ren C,Joshi T,Vuong T,Xu D,Nguyen HT

更新日期：2010-08-11 00:00:00

abstract：BACKGROUND:The astounding regenerative abilities of planarian flatworms prompt steadily growing interest in examining their molecular foundation. Planarian regeneration was found to require hundreds of genes and is hence a complex process. Thus, RNA interference followed by transcriptome-wide gene expression analysis b...

journal_title：BMC genomics

authors： Kim IV,Ross EJ,Dietrich S,Döring K,Sánchez Alvarado A,Kuhn CD

更新日期：2019-11-29 00:00:00

abstract：BACKGROUND:Pectobacterium spp. are necrotrophic bacterial plant pathogens of the family Pectobacteriaceae, responsible for a wide spectrum of diseases of important crops and ornamental plants including soft rot, blackleg, and stem wilt. P. carotovorum is a genetically heterogeneous species consisting of three valid sub...

journal_title：BMC genomics

authors： Li X,Ma Y,Liang S,Tian Y,Yin S,Xie S,Xie H

更新日期：2018-12-07 00:00:00

abstract：BACKGROUND:MicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in...

journal_title：BMC genomics

authors： Wang B,Ye N,Cao SJ,Wen XT,Huang Y,Yan QG

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:Zoysia matrella, widely used in lawns and sports fields, is of great economic and ecological value. Z. matrella is an allotetraploid species (2n = 4x = 40) in the genus zoysia under the subfamily Chloridoideae. Despite its ecological impacts and economic importance, the subfamily Chloridoideae has received l...

journal_title：BMC genomics

authors： Huang X,Wang F,Singh R,Reinert JA,Engelke MC,Genovesi AD,Chandra A,Yu Q

更新日期：2016-08-08 00:00:00

abstract：BACKGROUND:Gene expression variation is a key underlying factor influencing phenotypic variation, and can occur via cis- or trans-regulation. To understand the role of cis- and trans-regulatory variation on population divergence in chicken, we developed reciprocal crosses of two chicken breeds, White Leghorn and Cornis...

journal_title：BMC genomics

authors： Wang Q,Jia Y,Wang Y,Jiang Z,Zhou X,Zhang Z,Nie C,Li J,Yang N,Qu L

更新日期：2019-12-05 00:00:00

abstract：BACKGROUND:High-throughput proteomics was used to determine the role of the fish liver in defense responses to bacterial infection. This was done using a rainbow trout (Oncorhynchus mykiss) model following infection with Aeromonas salmonicida, the causative agent of furunculosis. The vertebrate liver has multifaceted f...

journal_title：BMC genomics

authors： Causey DR,Pohl MAN,Stead DA,Martin SAM,Secombes CJ,Macqueen DJ

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Regions of the genome that are under evolutionary constraint across multiple species have previously been used to identify functional sequences in the human genome. Furthermore, it is known that there is an inverse relationship between evolutionary constraint and the allele frequency of a mutation segregatin...

journal_title：BMC genomics

authors： Hodgkinson A,Casals F,Idaghdour Y,Grenier JC,Hernandez RD,Awadalla P

更新日期：2013-07-23 00:00:00

abstract：BACKGROUND:Crustaceans have been studied extensively as model systems for nervous system function from single neuron properties to behavior. However, lack of molecular sequence information and tools have slowed the adoption of these physiological systems as molecular model systems. In this study, we sequenced and perfo...

journal_title：BMC genomics

authors： Northcutt AJ,Lett KM,Garcia VB,Diester CM,Lane BJ,Marder E,Schulz DJ

更新日期：2016-11-04 00:00:00