Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor.

abstract：BACKGROUND:The compromised performance of laying hens in the late phase of production relative to the peak production was thought to be associated with the impairment of intestinal functionality, which plays essential roles in contributing to their overall health and production performance. In the present study, RNA se...

journal_title：BMC genomics

authors： Wang WW,Wang J,Zhang HJ,Wu SG,Qi GH

更新日期：2019-12-12 00:00:00

abstract：BACKGROUND:Bacteriophages are the most abundant and diverse entities in the biosphere, and this diversity is driven by constant predator-prey evolutionary dynamics and horizontal gene transfer. Phage genome sequences are under-sampled and therefore present an untapped and uncharacterized source of genetic diversity, ty...

journal_title：BMC genomics

authors： Oliveira H,Sampaio M,Melo LDR,Dias O,Pope WH,Hatfull GF,Azeredo J

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Heat shock proteins (Hsps) are molecular chaperones that are involved in many normal cellular processes and stress responses, and heat shock factors (Hsfs) are the transcriptional activators of Hsps. Hsfs and Hsps are widely coordinated in various biological processes. Although the roles of Hsfs and Hsps in ...

journal_title：BMC genomics

authors： Zhang J,Liu B,Li J,Zhang L,Wang Y,Zheng H,Lu M,Chen J

更新日期：2015-03-14 00:00:00

abstract：BACKGROUND:Small untranslated RNAs (sRNAs) seem to be far more abundant than previously believed. The number of sRNAs confirmed in E. coli through various approaches is above 70, with several hundred more sRNA candidate genes under biological validation. Although the total number of sRNAs in any one species is still un...

journal_title：BMC genomics

authors： Ulvé VM,Sevin EW,Chéron A,Barloy-Hubler F

更新日期：2007-12-19 00:00:00

abstract：BACKGROUND:Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity make the promoter attractive for in silico analysis and reporter gene studies in zebrafish (Danio re...

journal_title：BMC genomics

authors： Torgersen J,Nourizadeh-Lillabadi R,Husebye H,Aleström P

更新日期：2002-08-21 00:00:00

abstract：BACKGROUND:Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome. RESULTS:Using empirical estimates of recombination rate across the human geno...

journal_title：BMC genomics

authors： Sainudiin R,Clark AG,Durrett RT

更新日期：2007-06-06 00:00:00

abstract：BACKGROUND:Despite its relevance, almost no studies account for the genetic control in the early stages of tree development, i.e. from germination on. This study seeks to make a quite complete transcriptome for olive development and to elucidate the dynamic regulation of the transcriptomic response during the early-juv...

journal_title：BMC genomics

authors： Jiménez-Ruiz J,de la O Leyva-Pérez M,Vidoy-Mercado I,Barceló A,Luque F

更新日期：2018-11-19 00:00:00

abstract：BACKGROUND:Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic amino acids arginine and lysine, which results in functional maturation of the target protein. In vit...

journal_title：BMC genomics

authors： Turpeinen H,Kukkurainen S,Pulkkinen K,Kauppila T,Ojala K,Hytönen VP,Pesu M

更新日期：2011-12-20 00:00:00

abstract：BACKGROUND:Many species of the genus Prevotella are pathogens that cause oral diseases. Prevotella intermedia is known to cause various oral disorders e.g. periodontal disease, periapical periodontitis and noma as well as colonize in the respiratory tract and be associated with cystic fibrosis and chronic bronchitis. I...

journal_title：BMC genomics

authors： Ruan Y,Shen L,Zou Y,Qi Z,Yin J,Jiang J,Guo L,He L,Chen Z,Tang Z,Qin S

更新日期：2015-02-25 00:00:00

abstract：BACKGROUND:Protein structure comparison and classification is an effective method for exploring protein structure-function relations. This problem is computationally challenging. Many different computational approaches for protein structure comparison apply the secondary structure elements (SSEs) representation of prot...

journal_title：BMC genomics

authors： Ashby C,Johnson D,Walker K,Kanj IA,Xia G,Huang X

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Rumen epithelial tissue plays an important role in nutrient absorption and rumen health. However, whether forage quality and particle size impact the rumen epithelial morphology is unclear. The current study was conducted to elucidate the effects of forage quality and forage particle size on rumen epithelial...

journal_title：BMC genomics

authors： Wang B,Wang D,Wu X,Cai J,Liu M,Huang X,Wu J,Liu J,Guan L

更新日期：2017-05-06 00:00:00

abstract：BACKGROUND:The genetic mechanisms underlying hemangioblastoma development are still largely unknown. We used high-resolution single nucleotide polymorphism microarrays and droplet digital PCR analysis to detect copy number variations (CNVs) in total of 45 hemangioblastoma tumors. RESULTS:We identified 94 CNVs with a m...

journal_title：BMC genomics

authors： Mehrian-Shai R,Yalon M,Moshe I,Barshack I,Nass D,Jacob J,Dor C,Reichardt JK,Constantini S,Toren A

更新日期：2016-01-14 00:00:00

abstract：BACKGROUND:Horseradish peroxidases (HRPs) from Armoracia rusticana have long been utilized as reporters in various diagnostic assays and histochemical stainings. Regardless of their increasing importance in the field of life sciences and suggested uses in medical applications, chemical synthesis and other industrial ap...

journal_title：BMC genomics

authors： Näätsaari L,Krainer FW,Schubert M,Glieder A,Thallinger GG

更新日期：2014-03-24 00:00:00

abstract：BACKGROUND:Extra-cellular components, such as serum and exosome, have drawn great attention as a readily accessible source of biomarkers for mammalian health. However, the contribution of different blood components to the signature of respective microRNAs (miRNAs) remains unknown, especially in cattle. In this study we...

journal_title：BMC genomics

authors： Zhao K,Liang G,Sun X,Guan le L

更新日期：2016-08-12 00:00:00

abstract：BACKGROUND:The ultimate phenome of any organism is modulated by regulated transcription of many genes. Characterization of genetic makeup is thus crucial for understanding the molecular basis of phenotypic diversity, evolution and response to intra- and extra-cellular stimuli. Chickpea is the world's third most importa...

journal_title：BMC genomics

authors： Ashraf N,Ghai D,Barman P,Basu S,Gangisetty N,Mandal MK,Chakraborty N,Datta A,Chakraborty S

更新日期：2009-09-05 00:00:00

abstract：BACKGROUND:The complex genome of rapeseed (Brassica napus) is not well understood despite the economic importance of the species. Good knowledge of sequence variation is needed for genetics approaches and breeding purposes. We used a diversity set of B. napus representing eight different germplasm types to sequence gen...

journal_title：BMC genomics

authors： Bus A,Hecht J,Huettel B,Reinhardt R,Stich B

更新日期：2012-06-24 00:00:00

abstract：BACKGROUND:Sequencing data has become a standard measure of diverse cellular activities. For example, gene expression is accurately measured by RNA sequencing (RNA-Seq) libraries, protein-DNA interactions are captured by chromatin immunoprecipitation sequencing (ChIP-Seq), protein-RNA interactions by crosslinking immun...

journal_title：BMC genomics

authors： Kucukural A,Yukselen O,Ozata DM,Moore MJ,Garber M

更新日期：2019-01-05 00:00:00

abstract：BACKGROUND:Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a key player in many life-critical processes, including immune system and reproduction. Prolactin is a...

journal_title：BMC genomics

authors： Staley LA,Ebbert MT,Parker S,Bailey M,Alzheimer’s Disease Neuroimaging Initiative.,Ridge PG,Goate AM,Kauwe JS

更新日期：2016-06-29 00:00:00

abstract：BACKGROUND:The trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous leishmaniasis, African sleeping sickness, and Chagas disease. These protozoa possess complex life cycles that involve development in mammalian and insect hosts, ...

journal_title：BMC genomics

authors： Parsons M,Worthey EA,Ward PN,Mottram JC

更新日期：2005-09-15 00:00:00

abstract：BACKGROUND:Tumor angiogenesis is a highly regulated process involving intercellular communication as well as the interactions of multiple downstream signal transduction pathways. Disrupting one or even a few angiogenesis pathways is often insufficient to achieve sustained therapeutic benefits due to the complexity of a...

journal_title：BMC genomics

authors： Chen Y,Wei T,Yan L,Lawrence F,Qian HR,Burkholder TP,Starling JJ,Yingling JM,Shou J

更新日期：2008-06-02 00:00:00

abstract：BACKGROUND:Clostridium sticklandii belongs to a cluster of non-pathogenic proteolytic clostridia which utilize amino acids as carbon and energy sources. Isolated by T.C. Stadtman in 1954, it has been generally regarded as a "gold mine" for novel biochemical reactions and is used as a model organism for studying metabol...

journal_title：BMC genomics

authors： Fonknechten N,Chaussonnerie S,Tricot S,Lajus A,Andreesen JR,Perchat N,Pelletier E,Gouyvenoux M,Barbe V,Salanoubat M,Le Paslier D,Weissenbach J,Cohen GN,Kreimeyer A

更新日期：2010-10-11 00:00:00

abstract：BACKGROUND:Salinity is an abiotic stress that negatively affects soybean [Glycine max (L.) Merr.] seed yield. Although a major gene for salt tolerance was identified and consistently mapped to chromosome (Chr.) 3 by linkage mapping studies, it does not fully explain genetic variability for tolerance in soybean germplas...

journal_title：BMC genomics

authors： Do TD,Vuong TD,Dunn D,Clubb M,Valliyodan B,Patil G,Chen P,Xu D,Nguyen HT,Shannon JG

更新日期：2019-04-25 00:00:00

abstract：BACKGROUND:Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complexity of the sc datasets poses a great challenge in its utility and this problem is further exacerbate...

journal_title：BMC genomics

authors： Kumar N,Golhar R,Sharma KS,Holloway JL,Sarangi S,Neuhaus I,Walsh AM,Pitluk ZW

更新日期：2021-01-06 00:00:00

abstract：BACKGROUND:Acquisition of external phosphorus (P) and optimisation of internal P are essential for plant growth and development, and insufficient availability of P in soils is a major challenge in agriculture. Members of the purple acid phosphatase (PAP) family of enzymes are candidates for increasing P use efficiency....

journal_title：BMC genomics

authors： Xie L,Shang Q

更新日期：2018-08-31 00:00:00

abstract：BACKGROUND:The Spemann/Mangold organizer is a transient tissue critical for patterning the gastrula stage vertebrate embryo and formation of the three germ layers. Despite its important role during development, there are still relatively few genes with specific expression in the organizer and its derivatives. Foxa2 is ...

journal_title：BMC genomics

authors： Tamplin OJ,Kinzel D,Cox BJ,Bell CE,Rossant J,Lickert H

更新日期：2008-10-30 00:00:00

abstract：BACKGROUND:Transcriptomics in non-model plant systems has recently reached a point where the examination of nuclear genome-wide patterns in understudied groups is an achievable reality. This progress is especially notable in evolutionary studies of ferns, for which molecular resources to date have been derived primaril...

journal_title：BMC genomics

authors： Grusz AL,Rothfels CJ,Schuettpelz E

更新日期：2016-08-30 00:00:00

abstract：BACKGROUND:Microarray-based Comparative Genomic Hybridisation (CGH) has been used to assess genetic variability between bacterial strains. Crucial for interpretation of microarray data is the availability of a reference to compare signal intensities to reliably determine presence or divergence each DNA fragment. Howeve...

journal_title：BMC genomics

authors： Carpaij N,Fluit AC,Lindsay JA,Bonten MJ,Willems RJ

更新日期：2009-11-13 00:00:00

abstract：BACKGROUND:Ophiocordyceps sinensis is an important traditional Chinese medicine for its comprehensive active ingredients, such as cordycepin, cordycepic acid, and Cordyceps polysaccharide. O. sinensis zjut, a special strain isolated from O. sinensis, has similar pharmacological functions to wild O. sinensis. Currently,...

journal_title：BMC genomics

authors： Zhang B,Li B,Men XH,Xu ZW,Wu H,Qin XT,Xu F,Teng Y,Yuan SJ,Jin LQ,Liu ZQ,Zheng YG

更新日期：2020-12-11 00:00:00

abstract：BACKGROUND:NGS data contains many machine-induced errors. The most advanced methods for the error correction heavily depend on the selection of solid k-mers. A solid k-mer is a k-mer frequently occurring in NGS reads. The other k-mers are called weak k-mers. A solid k-mer does not likely contain errors, while a weak k-...

journal_title：BMC genomics

authors： Zhao L,Xie J,Bai L,Chen W,Wang M,Zhang Z,Wang Y,Zhao Z,Li J

更新日期：2018-12-31 00:00:00

abstract：BACKGROUND:Flow cytometry has been widely used for the diagnosis of various hematopoietic diseases. Although there have been advances in the number of biomarkers that can be analyzed simultaneously and technologies that enable fast performance, the diagnostic data are still interpreted by a manual gating strategy. The ...

journal_title：BMC genomics

authors： Shih MC,Huang SH,Donohue R,Chang CC,Zu Y

更新日期：2013-01-01 00:00:00