Abstract：
BACKGROUND:Congestion predominates in exacerbations of heart failure with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), but evidence suggests that excess volume may be distributed differently in these 2 subgroups. METHODS AND RESULTS:In this retrospective study, diuretic efficiency (DE, or net urine output per 40-mg of intravenous furosemide equivalent) during the first 72 hours was compared between patients hospitalized with HFrEF (n = 121) versus HFpEF (n = 120). Multivariate analysis was used to compare the 2 groups based on expected baseline differences (e.g., demographics, heart failure etiology, concomitant therapy). During the first 72 hours, mean daily diuretic doses were higher in patients with HFpEF versus HFrEF (172.0 vs. 159.9 mg, respectively, P = 0.026) but urine output was not significantly different (2603.3 mL vs. 2667.5 mL, respectively, adjusted P = 0.100). Similarly, mean cumulative DE did not differ (-673.5 vs. -637.8 mL/40-mg in the HFrEF and HFpEF groups, respectively, adjusted P = 0.884). An exploratory analysis of propensity-matched cohorts yielded similar findings. Correlations between the components of DE varied considerably and only became weak to moderately correlated toward the end of the observation period. CONCLUSIONS:Although cumulative DE did not differ between patients with HFrEF and HFpEF, variable correlations in the components of DE suggest there may be differences in diuretic response that warrant future analysis.
journal_name
J Cardiovasc Pharmacol Therjournal_title
Journal of cardiovascular pharmacology and therapeuticsauthors
Broscious R,Kukin A,Noel ZR,Devabhakthuni S,Seung H,Ramani GV,Reed BNdoi
10.1177/1074248420960930subject
Has Abstractpub_date
2021-03-01 00:00:00pages
165-172issue
2eissn
1074-2484issn
1940-4034journal_volume
26pub_type
杂志文章abstract：:Myocardial ischemic injury and cardioprotection are characterized by a cascade of molecular changes, which includes gene expression, protein expression, protein localization, interactions, and posttranslational modifications (PTMs). A systems biology approach allows the study of these genes and proteins on a large sca...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248411415855
更新日期：2011-09-01 00:00:00
abstract：:The gap junction modifier Rotigaptide (ZP123), which promotes cellular coupling, was hypothesized to decrease defibrillation thresholds during prolonged ventricular fibrillation (VF). Thirty-two New Zealand white rabbits were randomized to receive saline (control, n = 16) or Rotigaptide (n = 16). Following 4 min of un...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248406298021
更新日期：2007-03-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248418784288
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:In recent decades, clinical trials have played an increasingly important role in determining how we practice. Trial results proving that a clinical finding poses risk have led to interventions that try to reduce risk. Clinical trials proving that a particular therapy provides better outcome than another ther...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/107424840000500103
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To describe major events at follow up in octogenarian patients with atrial fibrillation (AF) according to anticoagulant treatment: direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). METHODS:A total of 578 anticoagulated patients aged ≥80 years with AF were included in a prospective, obse...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1177/1074248420916316
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248415617851
更新日期：2016-07-01 00:00:00
abstract：:We investigated the effect of erythropoietin (EPO) posttreatment on survival time and vascular functions in a mouse model of sepsis. Sepsis was induced by cecal ligation and puncture. After 20 ± 2 hours of sepsis, thoracic aorta was isolated for assessing its reactivity to norepinephrine (NE) and acetylcholine (ACh). ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/1074248415587968
更新日期：2016-01-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
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更新日期：2013-05-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/1074248418755120
更新日期：2018-05-01 00:00:00
abstract：:The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/1074248413482183
更新日期：2013-07-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248412453873
更新日期：2013-03-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840200700208
更新日期：2002-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/1074248416662348
更新日期：2017-03-01 00:00:00
abstract：:Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist remains a mainstay in the prevention of ischemic events following coronary stent placement. Significant controversy exists regarding the optimal management of high platelet reactivity despite antiplatelet therapy; however this finding has been cons...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1053/jcpt.1996.0219
更新日期：1996-07-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/1074248410385683
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abstract：:Effects of therapy with the potassium-channel opener and vasodilator nicorandil were studied in reperfused infarction of hypertrophied hearts by using magnetic resonance imaging (MRI), hemodynamic measurements, and histochemical staining. Aortic banding was performed on 22 Sprague-Dawley rats to induce left ventricula...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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doi：10.1177/107424840400900307
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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abstract：OBJECTIVE:Acute lung injury is a common complication after cardiopulmonary bypass (CPB). Oxidative damage greatly impacts CPB-induced lung ischemic pathogenesis and may represent a target for treatment. We aimed to investigate whether curcumin upregulates heme oxygenase 1 (HO-1) expression and ameliorates lung injury i...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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更新日期：2012-12-01 00:00:00
abstract：:BACKGROUND: Nicotine, the active agent in tobacco, is released into the circulation during cigarette smoking. It elevates plasma catecholamines, heart rate, and arterial blood pressure; produces coronary spasm; and increases myocardial work and oxygen demand with concomitant reduction in oxygen supply. This may genera...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849700200407
更新日期：1997-10-01 00:00:00
abstract：:BACKGROUND: The effectiveness of antisense oligodeoxynucleotides for in vitro and in vivo studies is limited by a low efficiency of cellular uptake and instability due to degradation by nucleases. To overcome some of these problems, we recently developed a transfer method that utilizes inactivated Sendai virus (hemagg...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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更新日期：1997-07-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1054/JCPT.2000.19245
更新日期：2000-10-01 00:00:00
abstract：:BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs incre...
journal_title：Journal of cardiovascular pharmacology and therapeutics
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更新日期：1996-04-01 00:00:00
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journal_title：Journal of cardiovascular pharmacology and therapeutics
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更新日期：2006-09-01 00:00:00
