当前位置： SCI文献检索 > JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS期刊下所有文献 > Comparison of the Electromechanical Effects of Vesnarinone and Amrinone in Isolated Dog Purkinje Strands and Ventricular Trabeculae.

Comparison of the Electromechanical Effects of Vesnarinone and Amrinone in Isolated Dog Purkinje Strands and Ventricular Trabeculae.

Abstract：

:BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs increased contractility of trabecular muscle preparations, while, in Purkinje strands, vesnarinone failed to increase developed force during continuous pacing at 2 Hz. Vesnarinone lengthened APD in both preparations; although this effect was more marked in Purkinje strands. Ventricular muscle APD was not affected by amrinone (1 µM to 1 mM), while, in Purkinje strands, amrinone produced a biphasic effect on APD. Low concentrations (1-100 µM) of amrinone shortened Purkinje fiber APD, while only the highest concentration (1 mM) used lengthened APD. In addition, in Purkinje strand preparations the effects of vesnarinone (10 µM) on APD and developed force were proportional to pacing cycle length at frequencies slower than 2 Hz; however, at frequencies faster than 2 Hz vesnarinone decreased developed force while APD was lengthened. In ventricular trabecular muscle preparations, the effects of vesnarinone were not affected by frequency. CONCLUSIONS: These results indicate clear differences between the effects of vesnarinone and amrinone in isolated cardiac preparations. These differences in experimental effects in isolated cardiac preparations may help provide an explanation for the disappointing clinical response of patients in heart failure to amrinone, while vesnarinone has appeared to be beneficial.

journal_name

J Cardiovasc Pharmacol Ther

journal_title

Journal of cardiovascular pharmacology and therapeutics

authors

Lathrop DA,Nánási PP,Varró A,Schwartz A

doi

10.1177/107424849600100207

keywords:

subject

Has Abstract

pub_date

1996-04-01 00:00:00

pages

133-140

issue

2

eissn

1074-2484

issn

1940-4034

pii

S1074248496000156

journal_volume

1

pub_type

杂志文章

相关文献

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS文献大全
  • Age-Related Considerations in Cardio-Oncology.

    abstract：:Cardio-Oncology has blossomed as a new field in cardiovascular medicine, in large part due to new therapies, which may have cardiovascular sequelae. Despite this, anthracyclines still serve as cornerstone therapy for most pediatric cancers, several solid tumors and hematological malignancies. Cardiotoxicity is the mai...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248420968689

    authors： Screever EM,Meijers WC,Moslehi JJ

    更新日期：2021-03-01 00:00:00

  • Stable cystatin C serum levels confirm normal renal function in patients with dronedarone-associated increase in serum creatinine.

    abstract：:Dronedarone is a new antiarrhythmic drug for patients with nonpermanent atrial fibrillation (AF). A relatively consistent finding in all trials studying dronedarone was a moderate but significant elevation of serum creatinine. Since dronedarone competes for the same organic cation transporter in the distal renal tubul...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248412453873

    authors： Duncker D,Oswald H,Gardiwal A,Lüsebrink U,König T,Schreyer H,Klein G

    更新日期：2013-03-01 00:00:00

  • Effect of Digoxin on Ventricular Remodeling and Responsiveness of beta-Adrenoceptors in Chronic Volume Overload.

    abstract：:BACKGROUND: Digoxin improves baroreflex function and reduces neurohumoral activation in severe heart failure, but it is uncertain how digoxin affects ventricular remodeling and progression to left ventricular dysfunction. In addition, the effect of digoxin in in vitro beta-adrenoceptor density and function, and contra...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849800300403

    authors： Sullebarger JT,D'Ambra PM,Clark LC,Thanikarry L,Fontanet HL

    更新日期：1998-10-01 00:00:00

  • Molecular Delivery System for Antisense Oligonucleotides: Enhanced Effectiveness of Antisense Oligonucleotides by HVJ-liposome Mediated Transfer.

    abstract：:BACKGROUND: The effectiveness of antisense oligodeoxynucleotides for in vitro and in vivo studies is limited by a low efficiency of cellular uptake and instability due to degradation by nucleases. To overcome some of these problems, we recently developed a transfer method that utilizes inactivated Sendai virus (hemagg...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849700200308

    authors： Morishita R,Gibbons GH,Horiuchi M,Nakajima M,Ellison KE,Lee W,Kaneda Y,Ogihara T,Dzau VJ

    更新日期：1997-07-01 00:00:00

  • Combination Use of Clopidogrel and Proton Pump Inhibitors Increases Major Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Meta-Analysis.

    abstract：BACKGROUND:Published data indicated that combination use of clopidogrel and proton pump inhibitors (PPIs) may increase the incidence of major adverse cardiovascular events (MACEs). This has been a highly controversial topic for years. DESIGN:The present study was performed to evaluate whether combination therapy of cl...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248416663647

    authors： Niu Q,Wang Z,Zhang Y,Wang J,Zhang P,Wang C,Yin X,Hou Y

    更新日期：2017-03-01 00:00:00

  • Harnessing the Therapeutic Potential of MicroRNAs for Cardiovascular Disease.

    abstract：:Cardiovascular diseases are one of the most common causes of death in humans and are responsible for billions of dollars in health care expenditures. As the molecular basis of cardiac diseases continues to be explored, there remains the hope for identification of more effective therapeutics. MicroRNAs (miRNAs) are rec...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1177/1074248414552902

    authors： Calway T,Kim GH

    更新日期：2015-03-01 00:00:00

  • Omapatrilat induces profound renal vasodilation but does not affect coronary hemodynamics.

    abstract：BACKGROUND:Omapatrilat has potent enzymatic inhibitory effects on the angiotensin-converting enzyme and neutral endopeptidase. The prolonged effects of this inhibition on systemic and regional hemodynamics, cardiovascular mass, and hydroxyproline concentration in spontaneously hypertensive rats were studied. The contri...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424840300800210

    authors： Varagic J,Susic D,Slama M,Frohlich ED

    更新日期：2003-06-01 00:00:00

  • Therapeutic Implications of COVID-19 for the Interventional Cardiologist.

    abstract：:Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complicat...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248420982736

    authors： Kelham M,Choudry FA,Hamshere S,Beirne AM,Rathod KS,Baumbach A,Ahluwalia A,Mathur A,Jones DA

    更新日期：2020-12-17 00:00:00

  • Mechanisms of Impaired Endothelial Function Associated With Insulin Resistance.

    abstract：:BACKGROUND: The insulin-resistant (IR) syndrome is causally related to hypertension and cardiovascular events; however, the underlying mechanism remains elusive. The current study was designed to determine (1) whether the IR syndrome causes vascular dysfunction and (2) whether insulin resistance alters the activity of...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849800300205

    authors： Miller AW,Hoenig ME,Ujhelyi MR

    更新日期：1998-04-01 00:00:00

  • Postconditioning markedly attenuates ventricular arrhythmias after ischemia-reperfusion.

    abstract：BACKGROUND:Brief periods of reocclusion (postconditioning) during early reperfusion reduce myocardial infarct size. Whether postconditioning has an effect on lethal ventricular arrhythmias independent of infarction in an in-vivo regional ischemia model is unknown. The purpose of this study was to determine if postcondi...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424840601100105

    authors： Kloner RA,Dow J,Bhandari A

    更新日期：2006-03-01 00:00:00

  • Intracoronary Administration of Allogeneic Cardiosphere-Derived Cells Immediately Prior to Reperfusion in Pigs With Acute Myocardial Infarction Reduces Infarct Size and Attenuates Adverse Cardiac Remodeling.

    abstract：BACKGROUND:Allogeneic cardiosphere-derived cells (CDCs) exert cardioprotective effects when administered intracoronarily after reperfusion in animal models of acute myocardial infarction (AMI). The "no-reflow" phenomenon develops rapidly post-reperfusion and may undermine the efficacy of cell therapy, due to poor cell ...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248420941672

    authors： Sousonis V,Sfakianaki T,Ntalianis A,Nanas I,Kontogiannis C,Aravantinos D,Kapelios C,Katsaros L,Nana M,Sampaziotis D,Sanoudou D,Papalois A,Malliaras K

    更新日期：2021-01-01 00:00:00

  • Local delivery of a hydrophobic heparin reduces neointimal hyperplasia after balloon injury in rat carotid but not pig coronary arteries.

    abstract：BACKGROUND:Intimal hyperplasia following percutaneous interventional vascular procedures is a major cause of restenosis. Although heparin inhibits intimal hyperplasia, it has not proven clinically useful in part due to an inadequate duration of intramural drug residence. This study was designed to evaluate the efficacy...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424840100600407

    authors： Sasseen BM,Gray BD,Gal D,Lorinc R,Carpenter DC,Klugherz BD,Wilensky RL

    更新日期：2001-10-01 00:00:00

  • Conversion of atrial fibrillation to sinus rhythm during treatment with intravenous esmolol or diltiazem: a prospective, randomized comparison.

    abstract：:Prior studies have suggested that intravenous diltiazem reduces the probability of spontaneous conversion of atrial fibrillation (AF) to sinus rhythm in the electrophysiology laboratory and in patients with postoperative AF. Whether diltiazem exerts the same effect in patients presenting to the emergency department (E...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1177/1074248407303792

    authors： Hassan S,Slim AM,Kamalakannan D,Khoury R,Kakish E,Maria V,Ahmed S,Pires LA,Kronick SL,Oral H,Morady F

    更新日期：2007-09-01 00:00:00

  • Comparison of bumetanide- and metolazone-based diuretic regimens to furosemide in acute heart failure.

    abstract：INTRODUCTION:Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF). Our purpose was to evaluate the comparative effect on urine output (UO) and renal function between these regimens. METHODS:A retrospective study of hospitali...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248413482755

    authors： Ng TM,Konopka E,Hyderi AF,Hshieh S,Tsuji Y,Kim BJ,Han SY,Phan DH,Jeng AI,Lou M,Elkayam U

    更新日期：2013-07-01 00:00:00

  • Persistence of Atrial Fibrillation After Its Induction-Importance of the Duration and Dispersion of Atrial Refractoriness and Electrical Remodeling.

    abstract：:BACKGROUND: The electrophysiologic mechanisms of the persistence of atrial fibrillation (AF) after its initiation are not well understood. Therefore, the electrophysiologic characteristics of the right atrium were evaluated in an acute, pacing-induced model of AF in the pig in order to identify parameters associated w...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849900400206

    authors： Rahme MM,Cotter B,Leistad E,Subudhayangkul S,Wadhwa M,Ungab G,Feld GK

    更新日期：1999-04-01 00:00:00

  • Astaxanthin reduces oxidative stress, but not aortic damage in atherosclerotic rabbits.

    abstract：:We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum ...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248409350136

    authors： Augusti PR,Conterato GM,Somacal S,Sobieski R,Quatrin A,Maurer L,Rocha MP,Denardin IT,Emanuelli T

    更新日期：2009-12-01 00:00:00

  • Antiplatelet Therapy Considerations in Ischemic Cardiogenic Shock: Implications of Metabolic Bioactivation.

    abstract：:Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist remains a mainstay in the prevention of ischemic events following coronary stent placement. Significant controversy exists regarding the optimal management of high platelet reactivity despite antiplatelet therapy; however this finding has been cons...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1177/1074248415571456

    authors： Weeks PA,Sieg A,Paruthi C,Rajapreyar I

    更新日期：2015-07-01 00:00:00

  • Antiarrhythmic and Arrhythmogenic Actions of Varying Levels of Extracellular Magnesium: Possible Cellular Basis for the Differences in the Efficacy of magnesium and Lidocaine in Torsade de Pointes.

    abstract：:BACKGROUND: In recent years, there has been an increasing use of antiarrhythmic drugs that act predominantly by prolonging myocardial repolarization. An inevitable electrophysiologic consequence of these drugs is the development of torsade de pointes as a proarrhythmic reaction. Both intravenous lidocaine and magnesiu...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849700200206

    authors： Takanaka C,Ogunyankin KO,Sarma JS,Singh BN

    更新日期：1997-04-01 00:00:00

  • Increasing doses of simvastatin versus combined ezetimibe/simvastatin: effect on circulating endothelial progenitor cells.

    abstract：BACKGROUND:Patients with coronary artery disease (CAD) should be treated with statins to attain very low cholesterol levels, in order to reduce cardiovascular adverse events. More than 70% of these patients do not reach the appropriate cholesterol goal despite moderate statin doses. However, it is not known whether the...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,随机对照试验

    doi：10.1177/1074248413489771

    authors： Pesaro AE,Serrano CV Jr,Katz M,Marti L,Fernandes JL,Parra PR,Campos AH

    更新日期：2013-09-01 00:00:00

  • Effects of pre- and postconditioning on arrhythmogenesis in the in vivo rat model.

    abstract：:The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248413482183

    authors： Kolettis TM,Vilaeti AD,Tsalikakis DG,Zoga A,Valenti M,Tzallas AT,Papalois A,Iliodromitis EK

    更新日期：2013-07-01 00:00:00

  • Hydrochlorothiazide Increases Efferent Glomerular Arteriolar Resistance in Spontaneously Hypertensive Rats.

    abstract：:BACKGROUND: Micropuncture studies were performed to determine the intrarenal hemodynamic effects of two conventional antihypertensive agents, hydrochlorothiazide (HCTZ) and hydralazine (HYDR) alone and in combination. METHODS AND RESULTS: Male spontaneously hypertensive and normotensive Wistar Kyoto rats (19 weeks old...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424849600100109

    authors： Komatsu K,Numabe A,Ono Y,Frohlich ED

    更新日期：1996-01-01 00:00:00

  • Platelet function testing and implications for clinical practice.

    abstract：:Platelets are key mediators in the pathophysiology of atherothrombotic disease. Inappropriate platelet activation can lead to thrombosis and ischemic events. Platelet function testing has been used to monitor patient response to antiplatelet therapy. Variability in response to antiplatelet therapy may be due in part t...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1177/1074248409339309

    authors： Collet JP,Montalescot G

    更新日期：2009-09-01 00:00:00

  • Dose dependency of fluvastatin pharmacokinetics in serum determined by reversed phase HPLC.

    abstract：BACKGROUND:Fluvastatin is an inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, effectively lowering serum cholesterol concentrations. A high-performance liquid chromatography (HPLC) assay was developed that determined the pharmacokinetics of fluvastatin in healthy individuals after administrat...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 临床试验,杂志文章

    doi：10.1177/107424840100600205

    authors： Siekmeier R,Lattke P,Mix C,Park JW,Jaross W

    更新日期：2001-04-01 00:00:00

  • Tedisamil in coronary disease: additional benefits in the therapy of atrial fibrillation?

    abstract：:Atrial fibrillation has recently come into clinical and research focus. In particular, ventricular rate control has been carefully compared with atrial rhythm control. Additionally, the recent discovery of atrial stunning has initiated clinical and research interest in atrial remodeling. Atrial fibrillation is more li...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1177/107424840300800105

    authors： Opie LH

    更新日期：2003-06-01 00:00:00

  • The importance of considering trial design when interpreting clinical trial results.

    abstract：BACKGROUND:In recent decades, clinical trials have played an increasingly important role in determining how we practice. Trial results proving that a clinical finding poses risk have led to interventions that try to reduce risk. Clinical trials proving that a particular therapy provides better outcome than another ther...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/107424840000500103

    authors： Reiffel JA

    更新日期：2000-01-01 00:00:00

  • Repurposing From Oncology to Cardiology: Low-Dose 5-Azacytidine Attenuates Pathological Cardiac Remodeling in Response to Pressure Overload Injury.

    abstract：INTRODUCTION:Recent evidence suggests that transcriptional reprogramming is involved in the pathogenesis of cardiac remodeling (cardiomyocyte hypertrophy and fibrosis) and the development of heart failure. 5-Azacytidine (5aza), an inhibitor of DNA methylation approved for hematological malignancies, has previously demo...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248420979235

    authors： Russell-Hallinan A,Neary R,Watson CJ,Baugh JA

    更新日期：2020-12-02 00:00:00

  • Exploring the Quality of Anticoagulant Prescribed for Patients With Atrial Fibrillation at the St John of God Hawkesbury District Health Centre, New South Wales, Australia.

    abstract：BACKGROUND:Limited data are available on the clinical management of atrial fibrillation (AF) and its outcomes from an Australian perspective. OBJECTIVE:To describe the appropriateness of antithrombotic prescribing for patients who presented with a diagnosis of AF to the Hawkesbury St John of God Hospital, New South Wa...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248418786264

    authors： Wertheimer G,Bereznicki LR

    更新日期：2019-01-01 00:00:00

  • Review article: the new concept of interventional heart failure therapy--part 1: electrical therapy, treatment of CAD, fluid removal, and ventricular support.

    abstract：:Congestive heart failure is a chronic and debilitating disease responsible for high cardiac morbidity and mortality in the world and is associated with more than 290 000 deaths in the United States each year. Recent advances in heart failure therapy target many of the mechanical and structural aspects of heart failure...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章,评审

    doi：10.1177/1074248410366447

    authors： Thompson KA,Philip KJ,Barbagelata A,Schwarz ER

    更新日期：2010-06-01 00:00:00

  • Effects of rotigaptide, a gap junction modifier, on defibrillation energy and resuscitation from cardiac arrest in rabbits.

    abstract：:The gap junction modifier Rotigaptide (ZP123), which promotes cellular coupling, was hypothesized to decrease defibrillation thresholds during prolonged ventricular fibrillation (VF). Thirty-two New Zealand white rabbits were randomized to receive saline (control, n = 16) or Rotigaptide (n = 16). Following 4 min of un...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248406298021

    authors： Zhong JQ,Laurent G,So PP,Hu X,Hennan JK,Dorian P

    更新日期：2007-03-01 00:00:00

  • Inhibition of Atherosclerosis Progression, Intimal Hyperplasia, and Oxidative Stress by Simvastatin and Ivabradine May Reduce Thoracic Aorta's Stiffness in Hypercholesterolemic Rabbits.

    abstract：AIMS:This study aims to evaluate atherosclerosis, oxidative stress, and arterial stiffness attenuation by simvastatin and ivabradine in hyperlipidemic rabbits. METHODS AND RESULTS:Forty rabbits were randomly divided into 4 groups: atherogenic diet (group C), atherogenic diet plus simvastatin (group S), atherogenic die...

    journal_title：Journal of cardiovascular pharmacology and therapeutics

    pub_type： 杂志文章

    doi：10.1177/1074248415617289

    authors： Koniari I,Mavrilas D,Apostolakis E,Papadimitriou E,Papadaki H,Papalois A,Poimenidi E,Xanthopoulou I,Hahalis G,Alexopoulos D

    更新日期：2016-07-01 00:00:00