Ventricular fibrillation induced by ischemia-reperfusion is not prevented by the NPY Y2 receptor antagonist BIIE0246.

abstract：INTRODUCTION:Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to furosemide in acute heart failure (HF). Our purpose was to evaluate the comparative effect on urine output (UO) and renal function between these regimens. METHODS:A retrospective study of hospitali...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Ng TM,Konopka E,Hyderi AF,Hshieh S,Tsuji Y,Kim BJ,Han SY,Phan DH,Jeng AI,Lou M,Elkayam U

更新日期：2013-07-01 00:00:00

abstract：:BACKGROUND: Circulating cells influence myocardial function during ischemia and reperfusion, (eg, neutrophils exacerbate, and platelets protect the myocardium from deterioration). This study was designed to determine the role of red blood cells on myocardial function following ischemia and reperfusion in isolated rat ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Yang BC,Nichols WW,Mehta JL

更新日期：1996-10-01 00:00:00

abstract：:The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kolettis TM,Vilaeti AD,Tsalikakis DG,Zoga A,Valenti M,Tzallas AT,Papalois A,Iliodromitis EK

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Intimal hyperplasia following percutaneous interventional vascular procedures is a major cause of restenosis. Although heparin inhibits intimal hyperplasia, it has not proven clinically useful in part due to an inadequate duration of intramural drug residence. This study was designed to evaluate the efficacy...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Sasseen BM,Gray BD,Gal D,Lorinc R,Carpenter DC,Klugherz BD,Wilensky RL

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:It is known that selective cyclooxygenase 2(COX-2) inhibitors increase mortality in patients with previous myocardial infarction, and it has been suggested that COX-2 plays an important role in cardioprotection against ischemia. The current study was carried out to determine whether COX-2 is involved in the mec...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Tosaka S,Tosaka R,Matsumoto S,Maekawa T,Cho S,Sumikawa K

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Fluvastatin is an inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, effectively lowering serum cholesterol concentrations. A high-performance liquid chromatography (HPLC) assay was developed that determined the pharmacokinetics of fluvastatin in healthy individuals after administrat...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Siekmeier R,Lattke P,Mix C,Park JW,Jaross W

更新日期：2001-04-01 00:00:00

abstract：:α-Lipoic acid (LA) has been shown to offer protection against ischemia-reperfusion injury (IRI) in multiple organ systems. N-[(R)-1,2-dithiolane-3-pentanoyl]-L-glutamyl-L-alanine (CMX-2043), a novel analogue of LA, was studied as part of a preclinical development program intended to identify safe and efficacious drug ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Baguisi A,Casale RA,Kates SA,Lader AS,Stewart K,Beeuwkes R 3rd

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:We investigated whether the cardioprotective, volatile gas anesthetic agent, isoflurane, could improve survival and organ function from hemorrhagic shock in an experimental rat model, compared to standard nonvolatile anesthetic agent ketamine/xylazine. METHODS:Sprague Dawley rats (both genders) were randomi...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Dai W,Shi J,Carreno J,Kloner RA

更新日期：2020-07-01 00:00:00

abstract：:Approximately 40% of heart attack survivors remain at increased risk of recurrent cardiovascular events, despite the current treatment options showing that atherothrombosis is not exclusively a disorder of lipoprotein aggregation in the arterial wall. Clinical and experimental data suggest that inflammation plays an i...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kottoor SJ,Arora RR

更新日期：2018-11-01 00:00:00

abstract：:BACKGROUND: Clinical trials have shown that the use of lipid-lowering agents in postmyocardial infarction (MI) patients reduces rates of subsequent coronary events, reduces coronary artery bypass surgery rates, and improves survival. Physician decisions to prescribe lipid-lowering drugs is influenced by a number of pa...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Khan M,Mukkamala A,Taylor DK,Espinosa A,Duff J

更新日期：1998-07-01 00:00:00

abstract：:Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhy...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Papp JG,Pollesello P,Varró AF,Végh AS

更新日期：2006-06-01 00:00:00

abstract：:Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist remains a mainstay in the prevention of ischemic events following coronary stent placement. Significant controversy exists regarding the optimal management of high platelet reactivity despite antiplatelet therapy; however this finding has been cons...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Weeks PA,Sieg A,Paruthi C,Rajapreyar I

更新日期：2015-07-01 00:00:00

abstract：:Effects of therapy with the potassium-channel opener and vasodilator nicorandil were studied in reperfused infarction of hypertrophied hearts by using magnetic resonance imaging (MRI), hemodynamic measurements, and histochemical staining. Aortic banding was performed on 22 Sprague-Dawley rats to induce left ventricula...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Schalla S,Higgins CB,Chujo M,Saeed M

更新日期：2004-09-01 00:00:00

abstract：:Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platele...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Przyklenk K,Whittaker P

更新日期：2017-09-01 00:00:00

abstract：:BACKGROUND: The insulin-resistant (IR) syndrome is causally related to hypertension and cardiovascular events; however, the underlying mechanism remains elusive. The current study was designed to determine (1) whether the IR syndrome causes vascular dysfunction and (2) whether insulin resistance alters the activity of...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Miller AW,Hoenig ME,Ujhelyi MR

更新日期：1998-04-01 00:00:00

abstract：:Myocardial ischemic injury and cardioprotection are characterized by a cascade of molecular changes, which includes gene expression, protein expression, protein localization, interactions, and posttranslational modifications (PTMs). A systems biology approach allows the study of these genes and proteins on a large sca...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Lotz C,Liem D,Ping P

更新日期：2011-09-01 00:00:00

abstract：AIMS:This study aims to evaluate atherosclerosis, oxidative stress, and arterial stiffness attenuation by simvastatin and ivabradine in hyperlipidemic rabbits. METHODS AND RESULTS:Forty rabbits were randomly divided into 4 groups: atherogenic diet (group C), atherogenic diet plus simvastatin (group S), atherogenic die...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Koniari I,Mavrilas D,Apostolakis E,Papadimitriou E,Papadaki H,Papalois A,Poimenidi E,Xanthopoulou I,Hahalis G,Alexopoulos D

更新日期：2016-07-01 00:00:00

abstract：:The presenting signs of osteogenic osteosarcoma are commonly pain, local swelling, local warmth, pathologic fracture, and metastatic disease. Deep venous metastasis of osteoblastic osteosarcoma is most often a postmortem diagnosis. This paper describes the case of a previously healthy 18-year-old woman who presented w...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Shah AP,Parmar S,O'Regan R

更新日期：2003-12-01 00:00:00

abstract：:BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs incre...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Lathrop DA,Nánási PP,Varró A,Schwartz A

更新日期：1996-04-01 00:00:00

abstract：:We present two patients who were diagnosed with symptomatic sinus node dysfunction in the setting of hypercalcemia secondary to hyperparathyroidism. An extensive review of the literature has not revealed previous reports of this pathologic process. ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Shah AP,Lopez A,Wachsner RY,Meymandi SK,El-Bialy AK,Ichiuji AM

更新日期：2004-06-01 00:00:00

abstract：:Dosing equivalency of carvedilol and metoprolol remains a debate. Degree of beta 1-blockade is best assessed by blunting of the exercise-induced heart rate. Accordingly, the authors have investigated dosing equivalency by examining baseline and peak exercise heart rates and norepinephrine levels in subjects with chron...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Vittorio TJ,Zolty R,Kasper ME,Khandwalla RM,Hirsh DS,Tseng CH,Jorde UP,Ahuja K

更新日期：2008-03-01 00:00:00

abstract：:Dofetilide is a class III antiarrhythmic agent approved by the Food and Drug Administration for the conversion of atrial fibrillation and atrial flutter and maintenance of sinus rhythm in symptomatic patients with persistent arrhythmia. Drug trials showed neutral mortality in post-myocardial infarction patients and th...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Wolbrette DL,Hussain S,Maraj I,Naccarelli GV

更新日期：2019-01-01 00:00:00

abstract：:Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complicat...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kelham M,Choudry FA,Hamshere S,Beirne AM,Rathod KS,Baumbach A,Ahluwalia A,Mathur A,Jones DA

更新日期：2020-12-17 00:00:00

abstract：:Homing of cardiac myosin-specific CD4-positive T cells into the myocardium is the initial pathologic event of experimental autoimmune myocarditis (EAM). Subsequently, various bystander inflammatory cells are recruited into the myocardium crossing vascular endothelial cell walls. Sulfated polysaccharide fucoidan binds ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Tanaka K,Ito M,Kodama M,Tomita M,Kimura S,Hoyano M,Mitsuma W,Hirono S,Hanawa H,Aizawa Y

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Dystrophin-deficient cardiomyopathy is a growing clinical problem without targeted treatments. We investigated whether nicorandil promotes cardioprotection in human dystrophin-deficient induced pluripotent stem cell (iPSC)-derived cardiomyocytes and the muscular dystrophy mdx mouse heart. METHODS AND RESULT...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Afzal MZ,Reiter M,Gastonguay C,McGivern JV,Guan X,Ge ZD,Mack DL,Childers MK,Ebert AD,Strande JL

更新日期：2016-11-01 00:00:00

abstract：:Qiliqiangxin (QL), a traditional Chinese medicine, has been shown to be beneficial for chronic heart failure. However, whether QL can also improve endothelial cell function in diabetic rats remains unknown. Here, we investigated the effect of QL treatment on endothelial dysfunction by comparing the effect of QL to tha...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Chen F,Wu JL,Fu GS,Mou Y,Hu SJ

更新日期：2015-03-01 00:00:00

abstract：:Beta-Adrenergic blockers have a wide spectrum of action for controlling cardiac arrhythmias that is larger than initially thought. Data from the past several decades indicate that, as an antiarrhythmic class, beta-blockers remain among the very few pharmacologic agents that reduce the incidence of sudden cardiac death...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Singh BN

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:To investigate the effect of a pharmacist care program on cardiovascular risks in type 2 diabetic patients. METHODS:A 9-month, prospective, randomized, controlled study was conducted in a public hospital in Hong Kong. Patients in the intervention group had regular drug-counseling sessions with pharmacists in...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Chan CW,Siu SC,Wong CK,Lee VW

更新日期：2012-03-01 00:00:00

abstract：:We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Augusti PR,Conterato GM,Somacal S,Sobieski R,Quatrin A,Maurer L,Rocha MP,Denardin IT,Emanuelli T

更新日期：2009-12-01 00:00:00

abstract：:The primary effect of ischemia is reduced aerobic adenosine triphosphate (ATP) formation in mitochondria. This triggers accelerated glycolysis and reduced cell pH, Ca(2+) accumulation, K(+) efflux, adenosine formation, and the clinical signs of ischemia: chest pain and a shift in the ST segment. Traditional therapies ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Stanley WC

更新日期：2004-09-01 00:00:00