Abstract：
:Dofetilide is a class III antiarrhythmic agent approved by the Food and Drug Administration for the conversion of atrial fibrillation and atrial flutter and maintenance of sinus rhythm in symptomatic patients with persistent arrhythmia. Drug trials showed neutral mortality in post-myocardial infarction patients and those with heart failure. This is a review of postmarket data, including real-world efficacy and safety in a variety of populations. Dofetilide has been used off-label with success in patients with paroxysmal atrial fibrillation and atrial flutter, as well as atrial tachycardia and ventricular tachycardia. The real-world acute conversion rate of atrial fibrillation and atrial flutter is higher than that reported in clinical trials. Dofetilide has an acceptable safety profile when initiated (or reloaded) under hospital monitoring and dosed according to creatinine clearance. Dofetilide is well tolerated and a good choice for patients with acceptable renal function and a normal QT interval, especially if atrioventricular nodal blockade needs to be avoided.
journal_name
J Cardiovasc Pharmacol Therjournal_title
Journal of cardiovascular pharmacology and therapeuticsauthors
Wolbrette DL,Hussain S,Maraj I,Naccarelli GVdoi
10.1177/1074248418784288subject
Has Abstractpub_date
2019-01-01 00:00:00pages
3-10issue
1eissn
1074-2484issn
1940-4034journal_volume
24pub_type
杂志文章,评审abstract：INTRODUCTION:Pulmonary hypertension (PH) is a potentially deadly disease for infants and adults with few existing medical interventions and no cure. In PH, increased blood pressure in the pulmonary artery eventually leads to heart failure. Fasudil, an antagonist of Rho-kinase, causes vasodilation leading to decreased s...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248418772814
更新日期：2018-09-01 00:00:00
abstract：:The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248413482183
更新日期：2013-07-01 00:00:00
abstract：:Low-molecular-weight heparins (LMWHs) endure as important drugs for thromboprophylaxis. Although clinical use relies on the subcutaneous (SC) route, our previous studies show that single-dose orally administered LMWHs have antithrombotic activity. Since thromboprophylaxis requires long-term treatment, we examined anti...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416667601
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To describe major events at follow up in octogenarian patients with atrial fibrillation (AF) according to anticoagulant treatment: direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). METHODS:A total of 578 anticoagulated patients aged ≥80 years with AF were included in a prospective, obse...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1177/1074248420916316
更新日期：2020-07-01 00:00:00
abstract：:Acute medical illnesses are associated with a prolonged elevation in inflammatory markers that predisposes patients to thrombosis beyond the duration of their hospital stay. In parallel, both observational and randomized data have demonstrated a rate of postdischarge venous thromboembolic events that often exceeds tha...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248415601894
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:Hypertension is a major cause of death and morbidity worldwide and is increasing in prevalence. The Renin-angiotensin system (RAS) is the most common mechanism involved in the pathophysiology of hypertension. Understanding the mechanism of the pathophysiologic processes will help direct potential therapeutic...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248419838503
更新日期：2019-09-01 00:00:00
abstract：:Lidocaine-sensitive, repetitive atrial tachycardia is an uncommon arrhythmia. The electrophysiologic substrate is still unknown, and the pharmacologic responses have not been fully explored. The aim of this study was to investigate the effects of intravenous adenosine and verapamil in patients with lidocaine-sensitive...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248411418971
更新日期：2012-06-01 00:00:00
abstract：:Dosing equivalency of carvedilol and metoprolol remains a debate. Degree of beta 1-blockade is best assessed by blunting of the exercise-induced heart rate. Accordingly, the authors have investigated dosing equivalency by examining baseline and peak exercise heart rates and norepinephrine levels in subjects with chron...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248407312629
更新日期：2008-03-01 00:00:00
abstract：:BACKGROUND: The tendency for the electrophysiologic effect of class III antiarrhythmic agents (action potential prolongation) to be diminished at faster heart rates represents a major drawback of this class of drug and is usually referred to as "reverse use dependence." A novel class III agent, MS-551, has recently be...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849700200105
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:The well-described morning peak in the onset of acute coronary syndromes has been partly attributed to increased platelet activity upon arising. It has been suggested that stent thrombosis (ST) exhibits a similar pattern. We assessed whether a diurnal variation in ST occurs, and whether more robust antiplate...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248413497534
更新日期：2013-11-01 00:00:00
abstract：:The existing clinical studies on remote ischemic preconditioning in patients undergoing cardiovascular surgery are critically reviewed, with a focus on infarct size reduction and clinical outcome as end points. Confounders, notably the use of propofol anesthesia are identified. The need for better designed trials with...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248416687874
更新日期：2017-07-01 00:00:00
abstract：:Ventricular remodeling is a compensatory response that comprises the processes of apoptosis, muscle cell hypertrophy, and rearrangement of the extracellular matrix fibers connecting the muscles. These processes are associated with transformation of endothelium and/or fibroblasts to myofibroblasts. Neutral matrix metal...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840200700407
更新日期：2002-10-01 00:00:00
abstract：BACKGROUND:We hypothesized that the cardioprotective effect of angiotensin II (AngII) type 1 receptor (AT(1)R) blockade during in vivo ischemia-reperfusion (IR) might be associated with an increase in AngII type 2 receptor (AT(2)R) protein, as well as 1,4,5-inositol trisphosphate type 2 receptor (IP(3)R) and protein ki...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1054/JCPT.2000.19245
更新日期：2000-10-01 00:00:00
abstract：:BACKGROUND: Nicotine, the active agent in tobacco, is released into the circulation during cigarette smoking. It elevates plasma catecholamines, heart rate, and arterial blood pressure; produces coronary spasm; and increases myocardial work and oxygen demand with concomitant reduction in oxygen supply. This may genera...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849700200407
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:epidemiologic studies indicate that elevated heart rate (HR) is an independent risk factor for mortality and morbidity in patients (pts) with chronic heart failure (CHF). Clinical trials with β-blockers suggest that HR reduction is an important mechanism of their benefit in pts with stable CHF. Pharmacologic...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248410370326
更新日期：2010-12-01 00:00:00
abstract：:Imipramine, an antidepressant drug, can cause potentially lethal cardiotoxic side effects including hypotension, ventricular tachycardia, and decreased cardiac output. This study investigated the mechanism responsible for imipramine-induced cardiac depression in rats. The left ventricular developed pressure (LVDP), ve...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248410366853
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND/AIM:In addition to its cholesterol-lowering effect, atorvastatin (ATV) has been thought to have multiple cardiovascular benefits, including anti-inflammatory and anti-apoptotic properties. The present study was undertaken to determine whether ATV pretreatment could attenuate myocardial apoptosis and inflamma...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416662348
更新日期：2017-03-01 00:00:00
abstract：AIMS:This study aims to evaluate atherosclerosis, oxidative stress, and arterial stiffness attenuation by simvastatin and ivabradine in hyperlipidemic rabbits. METHODS AND RESULTS:Forty rabbits were randomly divided into 4 groups: atherogenic diet (group C), atherogenic diet plus simvastatin (group S), atherogenic die...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248415617289
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Myocardial infarction causes the acidification of the cellular environment and the resultant acidosis maybe arrhythmogenic. The effect of acidosis on the action of antiarrhythmic drugs, an important issue in the antiarrhythmic drug therapy after myocardial infarction, remains to be studied. METHODS:To evalu...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840501000108
更新日期：2005-03-01 00:00:00
abstract：:BACKGROUND: The electrophysiologic mechanisms of the persistence of atrial fibrillation (AF) after its initiation are not well understood. Therefore, the electrophysiologic characteristics of the right atrium were evaluated in an acute, pacing-induced model of AF in the pig in order to identify parameters associated w...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849900400206
更新日期：1999-04-01 00:00:00
abstract：BACKGROUND:Insulin resistance (IR) is a well-known risk factor for cardiovascular complications. This study aimed to investigate the effect of a dietary model of IR in mice on cardiac remodeling, cardiac β-arrestin2 signaling, and the protective effects of carvedilol as a β-arrestin-biased agonist. METHODS AND RESULTS...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248420905683
更新日期：2020-07-01 00:00:00
abstract：:Vascular smooth muscle tone plays a fundamental role in regulating blood pressure, blood flow, microcirculation, and other cardiovascular functions. The cellular and molecular mechanisms by which vascular smooth muscle contractility is regulated are not completely elucidated. Recent studies show that the actin cytoske...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248407313737
更新日期：2008-06-01 00:00:00
abstract：:BACKGROUND: The effects of sotalol on the 24-hour profile of the QT interval relative to that of the heart rate (HR) may be helpful in determining the time course of the drug's action in controlling cardiac arhythmias. This has not been previously determined. Thus, the objective of the current study was to evaluate th...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849900400104
更新日期：1999-01-01 00:00:00
abstract：:The gap junction modifier Rotigaptide (ZP123), which promotes cellular coupling, was hypothesized to decrease defibrillation thresholds during prolonged ventricular fibrillation (VF). Thirty-two New Zealand white rabbits were randomized to receive saline (control, n = 16) or Rotigaptide (n = 16). Following 4 min of un...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248406298021
更新日期：2007-03-01 00:00:00
abstract：:Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platele...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248417724871
更新日期：2017-09-01 00:00:00
abstract：:Platelets are key mediators in the pathophysiology of atherothrombotic disease. Inappropriate platelet activation can lead to thrombosis and ischemic events. Platelet function testing has been used to monitor patient response to antiplatelet therapy. Variability in response to antiplatelet therapy may be due in part t...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248409339309
更新日期：2009-09-01 00:00:00
abstract：:The National Heart, Lung, and Blood Institute convened a Workshop on September 20-21, 2010, "New Horizons in Cardioprotection," to identify future research directions for cardioprotection against ischemia and reperfusion injury. Since the early 1970s, there has been evidence that the size of a myocardial infarction co...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type：
doi：10.1177/1074248411402501
更新日期：2011-09-01 00:00:00
abstract：BACKGROUND:Whether cardioprotection induced by the angiotensin II (AngII) type 2 receptor (AT(2)R) antagonist PD123,319 (PD) after ischemia-reperfusion (IR) is influenced by the concentration of PD, presence of AngII, timing of exposure, or inhibition of proton production from glucose metabolism is not known. METHODS ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1054/JCPT.2000.7451
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:In recent decades, clinical trials have played an increasingly important role in determining how we practice. Trial results proving that a clinical finding poses risk have led to interventions that try to reduce risk. Clinical trials proving that a particular therapy provides better outcome than another ther...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840000500103
更新日期：2000-01-01 00:00:00
abstract：:Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhy...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248406289286
更新日期：2006-06-01 00:00:00
