Abstract：
:Lidocaine-sensitive, repetitive atrial tachycardia is an uncommon arrhythmia. The electrophysiologic substrate is still unknown, and the pharmacologic responses have not been fully explored. The aim of this study was to investigate the effects of intravenous adenosine and verapamil in patients with lidocaine-sensitive atrial tachycardia. In 9 patients with repetitive uniform atrial tachycardia, the response to intravenous adenosine (12 mg), lidocaine (1 mg/kg body weight), and verapamil (10 mg) were sequentially investigated. Simultaneous 12-lead electrocardiogram (ECG) was recorded at baseline and continuously monitored thereafter. Tracings were obtained at regularly timed intervals right after the administration of each drug to evaluate changes in the arrhythmia characteristics. Repetitive atrial tachycardia was abolished by intravenous lidocaine in the 9 patients within the first 2 minutes after the end of injection. Adenosine suppressed the arrhythmia in 2 patients and shortened the runs of atrial ectopic activity in 1 patient, while verapamil was effective in 2 patients, 1 of them insensitive to adenosine and the other 1 sensitive to this agent. In 5 patients, the arrhythmia was abolished by radiofrequency ablation at different sites of the right atrium. Lidocaine-sensitive atrial tachycardia may eventually be also suppressed by adenosine and/or verapamil. This suggests that this enigmatic arrhythmia may be caused by different underlying electrophysiologic substrates and that at least in some cases, delayed afterdepolarizations seem to play a determining role.
journal_name
J Cardiovasc Pharmacol Therjournal_title
Journal of cardiovascular pharmacology and therapeuticsauthors
Chiale PA,Faivelis L,Garro HA,Fernández PA,Herrera Paz JJ,Elizari MVdoi
10.1177/1074248411418971subject
Has Abstractpub_date
2012-06-01 00:00:00pages
146-52issue
2eissn
1074-2484issn
1940-4034pii
1074248411418971journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Dystrophin-deficient cardiomyopathy is a growing clinical problem without targeted treatments. We investigated whether nicorandil promotes cardioprotection in human dystrophin-deficient induced pluripotent stem cell (iPSC)-derived cardiomyocytes and the muscular dystrophy mdx mouse heart. METHODS AND RESULT...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416636477
更新日期：2016-11-01 00:00:00
abstract：:BACKGROUND: Conventional microelectrode techniques were used to compare the concentration-dependent effects of vesnarinone (0.1-100 µM) and amrinone (1 µM-1 mM) on action potential duration (APD) and developed force in both isolated dog ventricular trabeculae and Purkinje strands. METHODS AND RESULTS: Both drugs incre...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849600100207
更新日期：1996-04-01 00:00:00
abstract：:Platelets are key mediators in the pathophysiology of atherothrombotic disease. Inappropriate platelet activation can lead to thrombosis and ischemic events. Platelet function testing has been used to monitor patient response to antiplatelet therapy. Variability in response to antiplatelet therapy may be due in part t...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248409339309
更新日期：2009-09-01 00:00:00
abstract：:Data obtained in both preclinical models and humans have revealed that the favorable cardiac consequences of ischemic conditioning extend beyond a direct effect on the cardiomyocyte. In the current review, we summarize our as-yet limited understanding of the complex relationships between ischemic conditioning, platele...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248417724871
更新日期：2017-09-01 00:00:00
abstract：:We investigated the effect of erythropoietin (EPO) posttreatment on survival time and vascular functions in a mouse model of sepsis. Sepsis was induced by cecal ligation and puncture. After 20 ± 2 hours of sepsis, thoracic aorta was isolated for assessing its reactivity to norepinephrine (NE) and acetylcholine (ACh). ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248415587968
更新日期：2016-01-01 00:00:00
abstract：:Phosphodiesterase inhibitors as inodilators in heart failure are associated with promotion of arrhythmias. Calcium sensitizers have been proposed for the treatment of severe decompensated heart failure. The effect of levosimendan, a calcium sensitizer, and milrinone, a phosphodiesterase inhibitor, on ventricular arrhy...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248406289286
更新日期：2006-06-01 00:00:00
abstract：PURPOSE:Methotrexate is an anti-inflammatory drug that has been shown to have anti-ischemic effects. Our aim was to evaluate if methotrexate could reduce infarct size in patients with ST-segment elevation myocardial infarction (STEMI). METHODS:We randomly assigned patients with STEMI to receive either methotrexate or ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248417699884
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:The administration of aspirin is traditionally discontinued prior to coronary artery bypass grafting (CABG), given a potential risk of excessive postoperative bleeding. Few studies have previously suggested the benefits of continuing aspirin until the time of surgery. The primary aim of this review is to eva...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,meta分析,评审
doi：10.1177/1074248413509026
更新日期：2014-01-01 00:00:00
abstract：:We evaluated whether carotenoid astaxanthin (ASX) could prevent oxidative and atherosclerotic damage in rabbits. Rabbits received regular chow (control) or an atherogenic diet (1% cholesterol) alone or supplemented with 50, 100, and 500 mg% ASX for 60 days (n = 5-9 per group). The atherogenic diet increased the serum ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248409350136
更新日期：2009-12-01 00:00:00
abstract：:BACKGROUND: The insulin-resistant (IR) syndrome is causally related to hypertension and cardiovascular events; however, the underlying mechanism remains elusive. The current study was designed to determine (1) whether the IR syndrome causes vascular dysfunction and (2) whether insulin resistance alters the activity of...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849800300205
更新日期：1998-04-01 00:00:00
abstract：:Dual antiplatelet therapy with aspirin and a P2Y12 receptor antagonist remains a mainstay in the prevention of ischemic events following coronary stent placement. Significant controversy exists regarding the optimal management of high platelet reactivity despite antiplatelet therapy; however this finding has been cons...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248415571456
更新日期：2015-07-01 00:00:00
abstract：:Acute medical illnesses are associated with a prolonged elevation in inflammatory markers that predisposes patients to thrombosis beyond the duration of their hospital stay. In parallel, both observational and randomized data have demonstrated a rate of postdischarge venous thromboembolic events that often exceeds tha...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248415601894
更新日期：2016-05-01 00:00:00
abstract：:Dofetilide is a class III antiarrhythmic agent approved by the Food and Drug Administration for the conversion of atrial fibrillation and atrial flutter and maintenance of sinus rhythm in symptomatic patients with persistent arrhythmia. Drug trials showed neutral mortality in post-myocardial infarction patients and th...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248418784288
更新日期：2019-01-01 00:00:00
abstract：:Postischemic accumulation of intracellular Na+ promotes calcium overload and contributes to cellular necrosis. Cardioprotection afforded by pharmacologic blockade of the sodium-hydrogen exchanger subtype 1 (NHE1) is thought to be more remarkable than that obtained by ischemic conditioning (IC). The window of protectio...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248418755120
更新日期：2018-05-01 00:00:00
abstract：:The results of numerous long-term, randomized trials show that statins significantly decrease the risks of myocardial infarction, stroke, and vascular death as well as total mortality. The benefits of statins on cardiovascular disease in patients who are not experiencing acute coronary syndromes generally become appar...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840400900i109
更新日期：2004-03-01 00:00:00
abstract：:α-Lipoic acid (LA) has been shown to offer protection against ischemia-reperfusion injury (IRI) in multiple organ systems. N-[(R)-1,2-dithiolane-3-pentanoyl]-L-glutamyl-L-alanine (CMX-2043), a novel analogue of LA, was studied as part of a preclinical development program intended to identify safe and efficacious drug ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248416640118
更新日期：2016-11-01 00:00:00
abstract：BACKGROUND:Patients with coronary artery disease (CAD) should be treated with statins to attain very low cholesterol levels, in order to reduce cardiovascular adverse events. More than 70% of these patients do not reach the appropriate cholesterol goal despite moderate statin doses. However, it is not known whether the...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248413489771
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:CVT-510, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside, is a selective A(1)-adenosine receptor agonist with potential potent antiarrhythmic effects in tachycardias involving the atrioventricular (AV) node. This study, the first in humans, was designed to determine the effects of CVT-510 on AV nodal condu...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1177/107424840100600304
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:To describe major events at follow up in octogenarian patients with atrial fibrillation (AF) according to anticoagulant treatment: direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). METHODS:A total of 578 anticoagulated patients aged ≥80 years with AF were included in a prospective, obse...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,多中心研究
doi：10.1177/1074248420916316
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Mortality after acute myocardial ischemia has been reduced by aspirin (ASA) but mechanisms other than the antiplatelet effect have not been established. This article evaluates an antiarrhythmic action during sympathetic stimulation in the intact anesthetized dog with and without ischemia. METHODS AND RESULT...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1053/XV.2000.5492
更新日期：2000-04-01 00:00:00
abstract：:BACKGROUND: The effectiveness of antisense oligodeoxynucleotides for in vitro and in vivo studies is limited by a low efficiency of cellular uptake and instability due to degradation by nucleases. To overcome some of these problems, we recently developed a transfer method that utilizes inactivated Sendai virus (hemagg...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849700200308
更新日期：1997-07-01 00:00:00
abstract：:Beta-Adrenergic blockers have a wide spectrum of action for controlling cardiac arrhythmias that is larger than initially thought. Data from the past several decades indicate that, as an antiarrhythmic class, beta-blockers remain among the very few pharmacologic agents that reduce the incidence of sudden cardiac death...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/10742484050100i402
更新日期：2005-06-01 00:00:00
abstract：:BACKGROUND: Clinical trials have shown that the use of lipid-lowering agents in postmyocardial infarction (MI) patients reduces rates of subsequent coronary events, reduces coronary artery bypass surgery rates, and improves survival. Physician decisions to prescribe lipid-lowering drugs is influenced by a number of pa...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424849800300303
更新日期：1998-07-01 00:00:00
abstract：BACKGROUND:Allogeneic cardiosphere-derived cells (CDCs) exert cardioprotective effects when administered intracoronarily after reperfusion in animal models of acute myocardial infarction (AMI). The "no-reflow" phenomenon develops rapidly post-reperfusion and may undermine the efficacy of cell therapy, due to poor cell ...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248420941672
更新日期：2021-01-01 00:00:00
abstract：:In previous studies, it was demonstrated that lipid core nanoparticles (LDE) resemble the low-density lipoprotein structure and carrying the antiproliferative agent paclitaxel (PTX) strongly reduced atherosclerosis lesions induced in rabbits by cholesterol feeding. Currently, the aim was to verify whether combining LD...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248418778836
更新日期：2018-11-01 00:00:00
abstract：BACKGROUND:Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were recently shown to be capable of electromechanical integration following direct injection into intact or recently injured guinea pig hearts, and hESC-CM transplantation in recently injured hearts correlated with improvements in contractile funct...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/1074248413520344
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To investigate the effect of a pharmacist care program on cardiovascular risks in type 2 diabetic patients. METHODS:A 9-month, prospective, randomized, controlled study was conducted in a public hospital in Hong Kong. Patients in the intervention group had regular drug-counseling sessions with pharmacists in...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,随机对照试验
doi：10.1177/1074248410396216
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Myocardial infarction causes the acidification of the cellular environment and the resultant acidosis maybe arrhythmogenic. The effect of acidosis on the action of antiarrhythmic drugs, an important issue in the antiarrhythmic drug therapy after myocardial infarction, remains to be studied. METHODS:To evalu...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章
doi：10.1177/107424840501000108
更新日期：2005-03-01 00:00:00
abstract：:Atrial fibrillation has recently come into clinical and research focus. In particular, ventricular rate control has been carefully compared with atrial rhythm control. Additionally, the recent discovery of atrial stunning has initiated clinical and research interest in atrial remodeling. Atrial fibrillation is more li...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/107424840300800105
更新日期：2003-06-01 00:00:00
abstract：:Vascular smooth muscle tone plays a fundamental role in regulating blood pressure, blood flow, microcirculation, and other cardiovascular functions. The cellular and molecular mechanisms by which vascular smooth muscle contractility is regulated are not completely elucidated. Recent studies show that the actin cytoske...
journal_title：Journal of cardiovascular pharmacology and therapeutics
pub_type： 杂志文章,评审
doi：10.1177/1074248407313737
更新日期：2008-06-01 00:00:00
