Mitofusin 2 inhibits angiotensin II-induced myocardial hypertrophy.

abstract：:Levosimendan increases the sensitivity of the cardiac fibrils to calcium, favorably affects hemodynamics in patients with heart failure. It is a positive inotrope and a peripheral vasodilator. The elimination half-life of the compound is about 1 hour. The drug decreases pulmonary capillary wedge pressure, increases ca...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kota B,Prasad AS,Economides C,Singh BN

更新日期：2008-12-01 00:00:00

abstract：:Cardio-Oncology has blossomed as a new field in cardiovascular medicine, in large part due to new therapies, which may have cardiovascular sequelae. Despite this, anthracyclines still serve as cornerstone therapy for most pediatric cancers, several solid tumors and hematological malignancies. Cardiotoxicity is the mai...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Screever EM,Meijers WC,Moslehi JJ

更新日期：2021-03-01 00:00:00

abstract：:Acute medical illnesses are associated with a prolonged elevation in inflammatory markers that predisposes patients to thrombosis beyond the duration of their hospital stay. In parallel, both observational and randomized data have demonstrated a rate of postdischarge venous thromboembolic events that often exceeds tha...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Korjian S,Daaboul Y,Halaby R,Goldhaber SZ,Cohen AT,Singh K,Susheela AT,Harrington RA,Hull RD,Hernandez AF,Gibson CM

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:Intimal hyperplasia following percutaneous interventional vascular procedures is a major cause of restenosis. Although heparin inhibits intimal hyperplasia, it has not proven clinically useful in part due to an inadequate duration of intramural drug residence. This study was designed to evaluate the efficacy...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Sasseen BM,Gray BD,Gal D,Lorinc R,Carpenter DC,Klugherz BD,Wilensky RL

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Hypertension is a major cause of death and morbidity worldwide and is increasing in prevalence. The Renin-angiotensin system (RAS) is the most common mechanism involved in the pathophysiology of hypertension. Understanding the mechanism of the pathophysiologic processes will help direct potential therapeutic...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Zhao Y,Ma R,Yu X,Li N,Zhao X,Yu J

更新日期：2019-09-01 00:00:00

abstract：:The results of numerous long-term, randomized trials show that statins significantly decrease the risks of myocardial infarction, stroke, and vascular death as well as total mortality. The benefits of statins on cardiovascular disease in patients who are not experiencing acute coronary syndromes generally become appar...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Novela C,Hennekens CH

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:Insulin resistance (IR) is a well-known risk factor for cardiovascular complications. This study aimed to investigate the effect of a dietary model of IR in mice on cardiac remodeling, cardiac β-arrestin2 signaling, and the protective effects of carvedilol as a β-arrestin-biased agonist. METHODS AND RESULTS...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Ibrahim WS,Ibrahim IAAE,Mahmoud MF,Mahmoud AAA

更新日期：2020-07-01 00:00:00

abstract：INTRODUCTION:Recent evidence suggests that transcriptional reprogramming is involved in the pathogenesis of cardiac remodeling (cardiomyocyte hypertrophy and fibrosis) and the development of heart failure. 5-Azacytidine (5aza), an inhibitor of DNA methylation approved for hematological malignancies, has previously demo...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Russell-Hallinan A,Neary R,Watson CJ,Baugh JA

更新日期：2020-12-02 00:00:00

abstract：:Neuropeptide Y is released together with norepinephrine from sympathetic nerve terminals during conditions of increased sympathetic activity. Neuropeptide Y is known to inhibit vagal activity, and accordingly, it might increase the risk for ventricular fibrillation during myocardial ischemia-reperfusion, with concomit...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Ilebekk A,Eriksen M,Sevre K,Aspelin T,Björkman JA,Lyberg T,Nordlander M

更新日期：2006-09-01 00:00:00

abstract：:Congestive heart failure is a chronic and debilitating disease responsible for high cardiac morbidity and mortality in the world and is associated with more than 290 000 deaths in the United States each year. Recent advances in heart failure therapy target many of the mechanical and structural aspects of heart failure...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Thompson KA,Philip KJ,Barbagelata A,Schwarz ER

更新日期：2010-06-01 00:00:00

abstract：:The antiarrhythmic potential of postconditioning in in vivo models remains poorly defined. We compared the effects of pre- and postconditioning on ventricular arrhythmogenesis against controls with and without reperfusion. Wistar rats (n = 40, 269 ± 3 g) subjected to ischemia (30 minutes)--reperfusion (24 hours) were ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kolettis TM,Vilaeti AD,Tsalikakis DG,Zoga A,Valenti M,Tzallas AT,Papalois A,Iliodromitis EK

更新日期：2013-07-01 00:00:00

abstract：:BACKGROUND: The effectiveness of antisense oligodeoxynucleotides for in vitro and in vivo studies is limited by a low efficiency of cellular uptake and instability due to degradation by nucleases. To overcome some of these problems, we recently developed a transfer method that utilizes inactivated Sendai virus (hemagg...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Morishita R,Gibbons GH,Horiuchi M,Nakajima M,Ellison KE,Lee W,Kaneda Y,Ogihara T,Dzau VJ

更新日期：1997-07-01 00:00:00

abstract：:A large body of evidence indicates that a persistently high heart rate is associated with a significant risk for higher mortality and sudden death in individuals with a variety cardiovascular disorders, as well as in the general population. Heart rates elevated beyond a certain threshold have been found to be a risk f...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Singh N

更新日期：2002-04-01 00:00:00

abstract：:We investigated the effect of erythropoietin (EPO) posttreatment on survival time and vascular functions in a mouse model of sepsis. Sepsis was induced by cecal ligation and puncture. After 20 ± 2 hours of sepsis, thoracic aorta was isolated for assessing its reactivity to norepinephrine (NE) and acetylcholine (ACh). ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Kandasamy K,Choudhury S,Singh V,Addison MP,Darzi SA,Kasa JK,Thangamalai R,Dash JR,Kumar T,Sultan F,Singh TU,Parida S,Mishra SK

更新日期：2016-01-01 00:00:00

abstract：:Myocardial ischemic injury and cardioprotection are characterized by a cascade of molecular changes, which includes gene expression, protein expression, protein localization, interactions, and posttranslational modifications (PTMs). A systems biology approach allows the study of these genes and proteins on a large sca...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Lotz C,Liem D,Ping P

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:In addition to its cholesterol-lowering effect, atorvastatin (ATV) has been thought to have multiple cardiovascular benefits, including anti-inflammatory and anti-apoptotic properties. The present study was undertaken to determine whether ATV pretreatment could attenuate myocardial apoptosis and inflamma...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Wang JY,Chen H,Su X,Zhou Y,Li L

更新日期：2017-03-01 00:00:00

abstract：:BACKGROUND: Circulating cells influence myocardial function during ischemia and reperfusion, (eg, neutrophils exacerbate, and platelets protect the myocardium from deterioration). This study was designed to determine the role of red blood cells on myocardial function following ischemia and reperfusion in isolated rat ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Yang BC,Nichols WW,Mehta JL

更新日期：1996-10-01 00:00:00

abstract：:Effects of therapy with the potassium-channel opener and vasodilator nicorandil were studied in reperfused infarction of hypertrophied hearts by using magnetic resonance imaging (MRI), hemodynamic measurements, and histochemical staining. Aortic banding was performed on 22 Sprague-Dawley rats to induce left ventricula...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Schalla S,Higgins CB,Chujo M,Saeed M

更新日期：2004-09-01 00:00:00

abstract：:Prior studies have suggested that intravenous diltiazem reduces the probability of spontaneous conversion of atrial fibrillation (AF) to sinus rhythm in the electrophysiology laboratory and in patients with postoperative AF. Whether diltiazem exerts the same effect in patients presenting to the emergency department (E...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Hassan S,Slim AM,Kamalakannan D,Khoury R,Kakish E,Maria V,Ahmed S,Pires LA,Kronick SL,Oral H,Morady F

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Mortality after acute myocardial ischemia has been reduced by aspirin (ASA) but mechanisms other than the antiplatelet effect have not been established. This article evaluates an antiarrhythmic action during sympathetic stimulation in the intact anesthetized dog with and without ischemia. METHODS AND RESULT...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Shehadeh AA,Arena J,Moschos CB,Regan TJ

更新日期：2000-04-01 00:00:00

abstract：:Antiplatelet therapy is indicated for the treatment of ischemic stroke or transient ischemic attack (TIA). Aspirin reduces subsequent occlusive vascular events, including recurrent stroke, by about 25%. In such patients, clopidogrel has been evaluated in an effort to further reduce risk. In the Management of Atherothr...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Gorelick P,Sechenova O,Hennekens CH

更新日期：2006-12-01 00:00:00

abstract：:Low-molecular-weight heparins (LMWHs) endure as important drugs for thromboprophylaxis. Although clinical use relies on the subcutaneous (SC) route, our previous studies show that single-dose orally administered LMWHs have antithrombotic activity. Since thromboprophylaxis requires long-term treatment, we examined anti...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Hiebert LM

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:CVT-510, N-(3(R)-tetrahydrofuranyl)-6-aminopurine riboside, is a selective A(1)-adenosine receptor agonist with potential potent antiarrhythmic effects in tachycardias involving the atrioventricular (AV) node. This study, the first in humans, was designed to determine the effects of CVT-510 on AV nodal condu...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Lerman BB,Ellenbogen KA,Kadish A,Platia E,Stein KM,Markowitz SM,Mittal S,Slotwiner DJ,Scheiner M,Iwai S,Belardinelli L,Jerling M,Shreeniwas R,Wolff AA

更新日期：2001-07-01 00:00:00

abstract：:The primary effect of ischemia is reduced aerobic adenosine triphosphate (ATP) formation in mitochondria. This triggers accelerated glycolysis and reduced cell pH, Ca(2+) accumulation, K(+) efflux, adenosine formation, and the clinical signs of ischemia: chest pain and a shift in the ST segment. Traditional therapies ...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Stanley WC

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Renalase is a protein that can regulate sympathetic nerve activity by metabolizing catecholamines, while redundant catecholamines are thought to contribute to atherosclerosis (As). Catecholamine release can be facilitated by angiotensin (Ang) II by binding to Ang II type 1 (AT1) receptors. Valsartan, a speci...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Zhou M,Ma C,Liu W,Liu H,Wang N,Kang Q,Li P

更新日期：2015-09-01 00:00:00

abstract：:BACKGROUND: The tendency for the electrophysiologic effect of class III antiarrhythmic agents (action potential prolongation) to be diminished at faster heart rates represents a major drawback of this class of drug and is usually referred to as "reverse use dependence." A novel class III agent, MS-551, has recently be...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Nakaya Y,Martin DK,Campbell TJ

更新日期：1997-01-01 00:00:00

abstract：:BACKGROUND: We determined if a single administration of heparin or nonanticoagulant N-acetylheparin could reduce myocardial injury resulting from a 90-minute occlusion of the left circumflex coronary artery (LCX) and 6 hours of reperfusion in the anesthetized canine. METHODS AND RESULTS: Heparin (2 mg/kg), N-acetylhep...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Gralinski MR,Driscoll EM,Friedrichs GS,DeNardis MR,Lucchesi BR

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:To describe major events at follow up in octogenarian patients with atrial fibrillation (AF) according to anticoagulant treatment: direct oral anticoagulants (DOACs) versus vitamin K antagonists (VKAs). METHODS:A total of 578 anticoagulated patients aged ≥80 years with AF were included in a prospective, obse...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Ortiz MR,Muñiz J,Esteve-Pastor MA,Marín F,Roldán I,Cequier A,Martínez-Sellés M,Saldivar HG,Bertomeu V,Anguita M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Dystrophin-deficient cardiomyopathy is a growing clinical problem without targeted treatments. We investigated whether nicorandil promotes cardioprotection in human dystrophin-deficient induced pluripotent stem cell (iPSC)-derived cardiomyocytes and the muscular dystrophy mdx mouse heart. METHODS AND RESULT...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Afzal MZ,Reiter M,Gastonguay C,McGivern JV,Guan X,Ge ZD,Mack DL,Childers MK,Ebert AD,Strande JL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) were recently shown to be capable of electromechanical integration following direct injection into intact or recently injured guinea pig hearts, and hESC-CM transplantation in recently injured hearts correlated with improvements in contractile funct...

journal_title：Journal of cardiovascular pharmacology and therapeutics

authors： Shiba Y,Filice D,Fernandes S,Minami E,Dupras SK,Biber BV,Trinh P,Hirota Y,Gold JD,Viswanathan M,Laflamme MA

更新日期：2014-07-01 00:00:00