Abstract:
Background:The purpose of this study was to determine the optimal puncture site of computed tomography (CT)-guided transthoracic needle aspiration biopsy for the diagnosis of tuberculosis (TB) by the comparison of clinical and radiological characteristics of TB patients stratified to different histopathological results. Methods:We retrospectively analysed the data of clinically diagnosed TB patients with negative laboratory results between July 2016 and June 2018. Biopsy specimens were obtained from patients for Ziehl-Neelsen (Z-N) staining and TB-DNA. Results:For the 356 TB patients, the positive rate of TB-DNA was 70.9%, which was significantly higher than that of Z-N staining (46.4%, P<0.001). The positive rate of lesions from upper lobe (76.4%, 155/203) was significantly higher than that from lower lobe (63.1%, 89/141, P=0.008). The mean of ΔCT density for positive histologic group (12.84±6.81 HU) was lower than that for negative histologic group (28.32±9.82 HU, P<0.001). ROC curve analysis revealed that a density-based cut-off value of 20.5 HU should be set as the cut-off values for determining the optimal puncture site. Conclusions:Our data demonstrates that the molecular diagnostics has superiority over Z-N staining for detecting MTB from lung aspirates. The lung biopsies from upper lobe were more likely to yield positive histologic results than those from lower lobe. In addition, the enhancement of 20.5 HU by CT scans should be set as the cut-off values for determining the optimal puncture site that would facilitate an efficient diagnosis of pulmonary TB.
journal_name
J Thorac Disjournal_title
Journal of thoracic diseaseauthors
Zhou Z,Dong Y,Li C,Wang D,Lv Y,Lv P,Pang Ydoi
10.21037/jtd-19-3293subject
Has Abstractpub_date
2020-08-01 00:00:00pages
3987-3994issue
8eissn
2072-1439issn
2077-6624pii
jtd-12-08-3987journal_volume
12pub_type
杂志文章abstract:Background:To investigate the epidemiological characteristics of 11 atypical pathogens of community-acquired pneumonia (CAP) among Chinese, and to determine whether or not there is an association between these pathogens and the severity of illness. Methods:We conducted a surveillance study for CAP in 30 hospitals of B...
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journal_title:Journal of thoracic disease
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.21037/jtd.2016.11.24
更新日期:2016-11-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
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更新日期:2018-03-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type:
doi:10.21037/jtd.2017.03.29
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pub_type: 杂志文章
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2072-1439.2015.11.63
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journal_title:Journal of thoracic disease
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journal_title:Journal of thoracic disease
pub_type: 杂志文章
doi:10.21037/jtd.2017.07.61
更新日期:2017-09-01 00:00:00
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journal_title:Journal of thoracic disease
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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